FB2025_01 , released February 20, 2025
Allele: Dmel\ImpL2MG2
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General Information
Symbol
Dmel\ImpL2MG2
Species
D. melanogaster
Name
FlyBase ID
FBal0249384
Feature type
allele
Associated gene
Dmel\ImpL2
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class

loss of function allele

Mutagen
Nature of the Allele
Allele class

loss of function allele

(Honegger et al., 2008)
Mutagen
ethyl methanesulfonate
(Honegger et al., 2008)
Progenitor genotype
P{EP}ImpL2EP5.66
(Honegger et al., 2008)
Cytology
Description

Amino acid replacement: W232term.

(Honegger et al., 2008)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
point_mutation
3L:4,225,009..4,225,009 [-]
Nucleotide change:

G4225009A

Amino acid change:

W235term | ImpL2-PA; W232term | ImpL2-PB; W236term | ImpL2-PC; W232term | ImpL2-PD

Reported amino acid change:

W235term

Comment:

G to A nucleotide change at the second or third position of the Trp codon leads to a nonsense mutation (exact site of mutation unspecified). Site of nucleotide substitution in mutant inferred by FlyBase based on reported amino acid change.

(Honegger et al., 2008)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      NOT Suppressor of
      Statement
      Reference

      ImpL2MG2, Scer\GAL4GMR.PF is a non-suppressor of visible phenotype of InRUAS.cHa, Scer\GAL4GMR.PF

      (Honegger et al., 2008)
      Phenotype Manifest In
      NOT Suppressor of
      Statement
      Reference

      ImpL2MG2, Scer\GAL4GMR.PF is a non-suppressor of eye phenotype of InRUAS.cHa, Scer\GAL4GMR.PF

      (Honegger et al., 2008)
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      ImpL2MG2 fails to suppresses the big eye phenotype resulting from the overexpression of InRScer\UAS.cHa driven by Scer\GAL4GMR.PF.

      (Honegger et al., 2008)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (4)
      Reported As
      Symbol Synonym
      EP5.66MG2
      (Honegger et al., 2008)
      Imp-L2-MG2
      (Bader et al., 2013)
      Imp-L2MG2
      (Honegger et al., 2008)
      ImpL2MG2
      Name Synonyms
      Secondary FlyBase IDs
        References (2)