Allele Dmel\Gr59c^Scer\UAS.cWa

General Information
Symbol	Dmel\Gr59c^Scer\UAS.cWa	Species	D. melanogaster
Name		FlyBase ID	FBal0249464
Feature type	allele	Associated gene	Dmel\Gr59c

Allele class
Mutagen	in vitro construct - regulatory fusion
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2013_03
FB2013_02
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Nature of the Allele
Allele class
Mutagen	in vitro construct - regulatory fusion (Weiss et al., 2011)
Mutations Mapped to the Genome

Type Location Additional Notes References
Associated Sequence Data
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name

UniProtKB/Swiss-Prot
UniProtKB/TrEMBL

Progenitor genotype
Nature of the lesion	Statement Reference Scer\UAS regulatory sequences drive expression of the Gr59c coding region. (Weiss et al., 2011)
Carried in construct	P{UAS-Gr59c.W} (Weiss et al., 2011, Weiss et al., 2011)
Cytology
Phenotypic Data
Phenotypic Class
	neurophysiology defective \| adult stage, with Scer\GAL4^Gr66a.1.8 (Weiss et al., 2011, Weiss et al., 2011)
Phenotype Manifest In
	I-type sensilla I5, with Scer\GAL4^Gr66a.1.8 (Weiss et al., 2011) I-type sensilla I8, with Scer\GAL4^Gr66a.1.8 (Weiss et al., 2011, Weiss et al., 2011) I-type sensilla I9, with Scer\GAL4^Gr66a.1.8 (Weiss et al., 2011, Weiss et al., 2011) I-type sensilla I10, with Scer\GAL4^Gr66a.1.8 (Weiss et al., 2011, Weiss et al., 2011) S-type sensilla S5, with Scer\GAL4^Gr66a.1.8 (Weiss et al., 2011, Weiss et al., 2011) S-type sensilla S6, with Scer\GAL4^Gr66a.1.8 (Weiss et al., 2011, Weiss et al., 2011)
Detailed Description
	Statement Reference Expression of Gr59c[Scer\UAS.cWa] under the control of Scer\GAL4[Gr66a.1.8] does not increase the electrophysiological response of bitter-responsive classes of labellar sensilla to azadirachtin or caffeine, but decreases the response in many cases. (Weiss et al., 2011) Expression of Gr59c[Scer\UAS.cWa] under the control of Scer\GAL4[Gr66a.1.8] confers strong electrophysiological responses to each of the bitter compounds BER, DEN and LOB in the I[[8]], I[[9]] and I[[10]] labellar sensilla (these sensilla do not normally respond to these compounds). Expression of Gr59c[Scer\UAS.cWa] under the control of Scer\GAL4[Gr66a.1.8] increases the electrophysiological response of the I[[5]], S[[5]] and S[[6]] labellar sensilla to each of the bitter compounds BER, DEN and LOB compared to the response seen in wild-type controls. (Weiss et al., 2011)
External Data
Linkouts
Interactions
Phenotypic Class
Phenotype Manifest In
Additional Comments
Genetic Interactions
Statement Reference
Xenogenetic Interactions
Statement Reference
Complementation & Rescue Data
Comments
Stocks ( 0 )

Notes on Origin
Discoverer

External Crossreferences & Linkouts
Other Crossreferences

Linkouts

Synonyms & Secondary IDs ( 1 )
Reported As
Symbol Synonym	Gr59c^Scer\UAS.cWa
Name Synonym
Secondary FlyBase IDs

References ( 2 )
Research paper	Weiss et al., 2011, Neuron 69(2): 258--272 The Molecular and Cellular Basis of Bitter Taste in Drosophila. [FBrf0212834]
Supplementary material	Weiss et al., 2011, Neuron 69(2): Supplemental Information. [FBrf0213039]

Allele Dmel\Gr59cScer\UAS.cWa

Allele Dmel\Gr59c^Scer\UAS.cWa