FB2025_01 , released February 20, 2025
Allele: Scer\GAL4GMR38H02
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General Information
Symbol
Scer\GAL4GMR38H02
Species
S. cerevisiae
Name
FlyBase ID
FBal0252116
Feature type
allele
Associated gene
Scer\GAL4
Associated Insertion(s)
Carried in Construct
P{GMR38H02-GAL4}
Also Known As
R38H02, R38H02-Gal4
Transgenic product class
Mutagen
Nature of the Allele
Transgenic product class
Mutagen
in vitro construct
(Pfeiffer et al., 2011.2.9)
Progenitor genotype
Carried in construct
P{GMR38H02-GAL4}
Cytology
Description

A 3977 base pair fragment from the flanking non-coding or intronic region of Nrt is fused upstream of a Drosophila core synthetic promoter (DSCP) that is followed by sequence encoding a GAL4 driver.

(Pfeiffer et al., 2011.2.9)
Allele components
Component
Use(s)
Regulatory region(s)
GMR38H02
Encoded product / tool
GAL4
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      distribution deduced from reporter (Gal4 UAS)
      Stage
      Tissue/Position (including subcellular localization)
      Reference
      adult stage
      ellipsoid body
      (Ofstad et al., 2011)
      adult brain | restricted
      (Ofstad et al., 2011)
      ellipsoid body | intense | restricted
      (Jenett and Svirskas, 2012.9.24)
      bulb | intense | restricted
      (Jenett and Svirskas, 2012.9.24)
      adult mushroom body | intense | restricted
      (Jenett and Svirskas, 2012.9.24)
      adult antennal lobe | intense | restricted
      (Jenett and Svirskas, 2012.9.24)
      Additional Information
      Statement
      Reference

      ScerGAL4GMR38H02 drives expression in a different subset of ellipsoid body neurons than either ScerGAL4GMR15B07 or ScerGAL4GMR28D01.

      (Ofstad et al., 2011)
       
      Marker for
      ellipsoid body
      (Ofstad et al., 2011)
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Inhibition (using Hsap\KCNJ2AAE.UAS.EGFP) of Scer\GAL4GMR38H02 cells in adults significantly reduces the preference to orient towards a dark vertical bar on the side where the same bar had not been shown previously, rather than a bar on the side where the same bar had been transiently shown previously, compared to controls; there is no effect on innate left/right preference between two dark vertical bars, or ability to orient towards a single bar, compared to controls.

      (Shiozaki and Kazama, 2017)

      Inhibition (using Hsap\KCNJ2UAS.cUa.EGFP) of Scer\GAL4GMR38H02 cells, in combination with a Gal80[ts] transgene to restrict expression to the adult stage, abolishes the significant increase in preference for food (vinegar) odor seen in starved versus fed flies, compared to controls.

      Activation (using Bhal\NaChBacUAS.cNa) of Scer\GAL4GMR38H02 cells in adults abolishes the significant decrease in preference for food (vinegar) odor seen in fed versus starved flies, compared to controls.

      (Park et al., 2016)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      NOT Enhanced by
      Statement
      Reference

      KCNQJF02562, Scer\GAL4GMR38H02 has abnormal feeding behavior | adult stage | nutrition conditional phenotype, non-enhanceable by SLC5A11EY21708

      (Park et al., 2016)
      NOT suppressed by
      Statement
      Reference

      KCNQJF02562, Scer\GAL4GMR38H02 has abnormal feeding behavior | adult stage | nutrition conditional phenotype, non-suppressible by SLC5A11EY21708

      (Park et al., 2016)
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (1)
      Reported As
      Symbol Synonym
      Scer\GAL4GMR38H02
      Name Synonyms
      Secondary FlyBase IDs
        References (11)