FB2025_05 , released December 11, 2025
Allele: Scer\GAL4GMR45D07
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General Information
Symbol
Scer\GAL4GMR45D07
Species
S. cerevisiae
Name
FlyBase ID
FBal0252669
Feature type
allele
Associated gene
Scer\GAL4
Associated Insertion(s)
Carried in Construct
P{GMR45D07-GAL4}
Also Known As
R45D07, R45D07-GAL4
Transgenic product class
Mutagen
Nature of the Allele
Transgenic product class
Mutagen
in vitro construct
(Pfeiffer et al., 2011.2.9)
Progenitor genotype
Carried in construct
P{GMR45D07-GAL4}
Cytology
Description

A 3606 base pair fragment from the flanking non-coding or intronic region of hth is fused upstream of a Drosophila core synthetic promoter (DSCP) that is followed by sequence encoding a GAL4 driver.

(Pfeiffer et al., 2011.2.9)
Allele components
Component
Use(s)
Regulatory region(s)
GMR45D07
Encoded product / tool
GAL4
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      distribution deduced from reporter (Gal4 UAS)
      Stage
      Tissue/Position (including subcellular localization)
      Reference
      adult stage
      antennal mechanosensory and motor center B1 projection neuron
      (Yamada et al., 2018, Vaughan et al., 2014)
      wedge | faint | restricted
      (Vaughan et al., 2014)
      projection neuron | subset of prothoracic leg
      (Vaughan et al., 2014)
      leg | restricted
      (Vaughan et al., 2014)
      abdominal nerve | faint | restricted
      (Vaughan et al., 2014)
      Additional Information
      Statement
      Reference

      ScerGAL4GMR45D07 drives expression mainly in antennal mechanosensory and motor center B1 projection neuron, but also drives expression in a projection neuron from the prothoracic leg, faintly in a wedge neuron, minor innervation in the leg, with minor expression also in the terminal abdominal nerve.

      (Vaughan et al., 2014)
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Inhibition (using Ctet\tetXTNT-LC.UAS) of Scer\GAL4GMR45D07 cells significantly diminishes the responses of wedge projection neurons to the onset of wind and slightly reduces the tonic wind response; inhibition of the combined set of Scer\GAL4GMR24C06 and Scer\GAL4GMR45D07 cells does not significantly reduce the responses of wedge projection neurons to the onset of wind or reduce the tonic wind response.

      Optogenetic activation (using Cnoc\ChR1::Csub\ChRCsChrimson.IVS.20xUAS.Venus) of Scer\GAL4GMR45D07 cells results in a transient hyperpolarization of wedge projection neurons, relative to controls.

      (Suver et al., 2019)

      Inhibition (using Ctet\tetXTNT-LC.UAS) of Scer\GAL4GMR45D07 cells in adult females significantly increases their copulation rate in response to pulse song at a range of inter-pulse intervals, compared to controls.

      (Yamada et al., 2018)

      Inhibition (using shi1.UAS at 30[o]C) of Scer\GAL4GMR45D07 neurons in adult females significantly reduces receptivity to mating, compared to controls; in males, courtship pulse song-induced locomotion is significantly reduced, compared to controls.

      Thermogenetic activation (using TrpA1UAS.(B).cKa at 27[o]C) of Scer\GAL4GMR45D07 neurons in adult females significantly reduces receptivity to mating, compared to controls.

      (Vaughan et al., 2014)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (1)
      Reported As
      Symbol Synonym
      Scer\GAL4GMR45D07
      Name Synonyms
      Secondary FlyBase IDs
        References (7)