FB2025_01 , released February 20, 2025
Allele: Scer\GAL4GMR64H06
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General Information
Symbol
Scer\GAL4GMR64H06
Species
S. cerevisiae
Name
FlyBase ID
FBal0254012
Feature type
allele
Associated gene
Scer\GAL4
Associated Insertion(s)
Carried in Construct
P{GMR64H06-GAL4}
Also Known As
R64H06, R64H06-Gal4
Transgenic product class
Mutagen
Nature of the Allele
Transgenic product class
Mutagen
in vitro construct
(Pfeiffer et al., 2011.2.9)
Progenitor genotype
Carried in construct
P{GMR64H06-GAL4}
Cytology
Description

A 3939 base pair fragment from the flanking non-coding or intronic region of amn is fused upstream of a Drosophila core synthetic promoter (DSCP) that is followed by sequence encoding a GAL4 driver.

(Pfeiffer et al., 2011.2.9)
Allele components
Component
Use(s)
Regulatory region(s)
GMR64H06
Encoded product / tool
GAL4
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      distribution deduced from reporter (Gal4 UAS)
      Stage
      Tissue/Position (including subcellular localization)
      Reference
      third instar larval stage
      larval dopaminergic pPAM neuron
      (Rohwedder et al., 2016)
      larval mushroom body dopaminergic neuron h1
      (Saumweber et al., 2018)
      larval mushroom body dopaminergic neuron i1
      (Saumweber et al., 2018)
      larval mushroom body dopaminergic neuron j1
      (Saumweber et al., 2018)
      larval mushroom body dopaminergic neuron k1
      (Saumweber et al., 2018)
      adult stage
      prow | restricted
      (Jenett and Svirskas, 2012.9.24)
      ellipsoid body | faint | restricted
      (Jenett and Svirskas, 2012.9.24)
      bulb | intense | restricted
      (Jenett and Svirskas, 2012.9.24)
      adult brain | restricted
      (Shuai et al., 2015)
      mushroom body extrinsic neuron
      (Shuai et al., 2015)
      mushroom body gamma lobe slice 1
      (Shuai et al., 2015)
      mushroom body gamma lobe slice 3
      (Shuai et al., 2015)
      mushroom body gamma lobe slice 4
      (Shuai et al., 2015)
      mushroom body gamma lobe slice 5
      (Shuai et al., 2015)
      mushroom body beta lobe slice 1
      (Shuai et al., 2015)
      mushroom body beta lobe slice 2
      (Shuai et al., 2015)
      mushroom body beta' lobe slice 1
      (Shuai et al., 2015)
      mushroom body beta' lobe slice 2
      (Shuai et al., 2015)
      LNd neuron | subset
      (Sekiguchi et al., 2020)
      adult s-LNv neuron | subset
      (Sekiguchi et al., 2020)
      l-LNv neuron | subset
      (Sekiguchi et al., 2020)
      Pdf negative s-LNv neuron | subset
      (Sekiguchi et al., 2020)
      Additional Information
      Statement
      Reference

      ScerGAL4GMR64H06 drives expression in ple positive larval dopaminergic pPAM neurons.

      (Rohwedder et al., 2016)

      ScerGAL4GMR64H06 drives expression in mushroom body extrinsic neurons that innervate mushroom body gamma lobe slices 1, 3, 4 and 5, mushroom body beta lobe slices 1 and 2, and mushroom body beta' lobe slices 1 and 2.

      (Shuai et al., 2015)
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Ablation (using hidUAS.cUa and rprUAS.cUa) of Scer\GAL4GMR64H06 neurons significantly impairs short-term appetitive olfactory memory following training with fructose, arabinose or sorbitol, compared to controls; there is no effect on aversive olfactory memory following training with quinine, compared to controls.

      (Rohwedder et al., 2016)

      Inhibition (using Hsap\KCNJ2UAS.EGFP) of Scer\GAL4GMR64H06 neurons, in combination with a Gal80[ts] transgene to restrict expression to 1 day prior to training and testing, does not affect 3 hour aversive olfactory memory, compared to controls.

      (Shuai et al., 2015)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (1)
      Reported As
      Symbol Synonym
      Scer\GAL4GMR64H06
      Name Synonyms
      Secondary FlyBase IDs
        References (9)