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General Information
Symbol
Dmel\ERR1
Species
D. melanogaster
Name
FlyBase ID
FBal0256727
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Also Known As
dERR1
Key Links
Allele class
Nature of the Allele
Allele class
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Cytology
Nature of the lesion
Statement
Reference

The following mutations have been introduced into ERR : an 82 bp deletion which removes the splice acceptor site in the second exon of both isoforms, an insertion of an AscI restriction enzyme site after Thr108 which generates a frameshift mutation with a premature stop codon, and a 7bp deletion surrounding Cys414 (replacing it with ggcgcggg).

Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 1 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Disease-implicated variant(s)
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

ERR1/ERR2 mutants progress normally through embryogenesis and first instar development, but die abruptly during the later half of the second larval instar with no obvious morphological defects. Mutants are severely metabolically compromised, with a 2-fold decrease in ATP levels relative to control larvae. Normal glycogen concentrations and elevated circulating trehalose concentrations are observed in these animals. TAG levels are decreased in these mutants. An 85-90% decrease in lactate is observed in these mutants. Variations in the levels of other metabolites is observed compared to control animals.

ERR1/Df(3L)Exel6112 mutants display metabolic defects.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Phenotype Manifest In
Additional Comments
Genetic Interactions
Statement
Reference

Expression of PgiScer\UAS.cTa and PfkScer\UAS.cTa under the control of Scer\GAL4da.G32 rescues the elevated trehalose levels of ERR1/ERR2 mutant larvae. 8% of rescued larvae complete larval development an pupariate, compared to 1% of ERR1/ERR2 control animals.

Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Images (0)
Mutant
Wild-type
Stocks (1)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (2)
Reported As
Name Synonyms
Secondary FlyBase IDs
    References (3)