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General Information
Symbol
Dmel\Gr64a1
Species
D. melanogaster
Name
FlyBase ID
FBal0256892
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Also Known As
ΔGr64a1, ΔGr64a
Nature of the Allele
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Cytology
Nature of the lesion
Statement
Reference

Imprecise excision of the progenitor insertion, resulting in a deletion which removes part of the protein coding region of Gr64a (including the translation start codon).

Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

Gr64a1 mutants exhibit a statistically significant reduction in the response to sucrose, maltose, maltotriose, fructose and glycerol. However, responses to trehalose, melezitose, m-glucoside, and glucose are unaffected.

The L-type labellar sensilla of homozygous, Gr64a1/Df(3L)Gr64a2 and Gr64a1/Df(3L)GN34 flies show almost no electrophysiological response to either maltotriose, stachyose, raffinose, leucrose or fructose. The response to sucrose, maltose, turanose, maltitol and palatinose is reduced compared to wild type, but not abolished. The response to m-α-glucoside, glucose and melezitose is not reduced in the mutant flies, and the response to glucose may be somewhat elevated.

The mean proboscis extension response of homozygous flies to fructose, stachyose, maltotriose, maltose and sucrose is reduced compared to controls, but the response to glucose, melezitose and m-α-glucoside is not affected.

The number of proboscis extension responses in 30 seconds in a walking proboscis extension assay is severely reduced in Gr64a1/Df(3L)Gr64a2 flies compared to controls in response to either maltotriose or sucrose.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Phenotype Manifest In
Additional Comments
Genetic Interactions
Statement
Reference

SLC5A11EY21708 Gr64a1 Gr5aunspecified triple mutants show an equal preference for D-glucose and L-glucose in a two-choice assay after 18 hours of starvation.

Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Partially rescued by
Comments

The defects in the electrophysiological response to various sugars which is seen in the L-type labellar sensilla of Gr64a1/Df(3L)Gr64a2 flies are rescued by expression of Gr64aScer\UAS.cDa under the control of Scer\GAL4Gr5a.8.5.

Expression of Gr64aScer\UAS.cDa under the control of Scer\GAL4Gr5a.8.5 increases the mean proboscis extension response to all sugars whose responses are reduced in Gr64a1 flies.

Expression of Gr64aScer\UAS.cDa under the control of Scer\GAL4Gr5a.8.5 partially rescues the reduced proboscis extension responses to maltotriose and sucrose which are seen in a walking proboscis extension assay in Gr64a1/Df(3L)Gr64a2 flies.

Images (0)
Mutant
Wild-type
Stocks (0)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (4)
Reported As
Name Synonyms
Secondary FlyBase IDs
    References (7)