FB2025_01 , released February 20, 2025
Allele: Dmel\EndoGIGScE6
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General Information
Symbol
Dmel\EndoGIGScE6
Species
D. melanogaster
Name
FlyBase ID
FBal0256909
Feature type
allele
Associated gene
Dmel\EndoGI
Associated Insertion(s)
P{GSV1}EndoGIGScE6
Carried in Construct
Key Links
Genomic Maps

Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
Delta2-3 transposase
(O'Keefe et al., 2011)
Progenitor genotype
Associated Insertion(s)
P{GSV1}EndoGIGScE6
Cytology
Description

Insertion within the first intron of PRL-1 and approximately 6300bp upstream of the start codon of the neighbouring EndoGI gene. Expression from the Scer\UAS sites in the P{GSV1} element using a Scer\GAL4 driver results in overexpression of both PRL-1 and EndoGI.

(O'Keefe et al., 2011)
Allele components
Component
Use(s)
Inserted element
P{GSV1}
Regulatory region(s)
UASt
Mutations Mapped to the Genome
Curation Data
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Animals containing clones in the eye (generated using the ey-FLP system) expressing EndoGIGScE6 under the control of Scer\GAL4Act5C.PP show an increase in eye size compared to controls.

      Expression of EndoGIGScE6 under the control of Scer\GAL4en-e16E results in a 25% increase in the size of the posterior wing. In addition, the majority of wing vein material is absent in the posterior part of the wing.

      Clones of cells expressing EndoGIGScE6 under the control of Scer\GAL4Act5C.PP in the wing disc generally contain more cells than control clones (the cell size and cell cycle profile is normal).

      (O'Keefe et al., 2011)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (1)
      Reported As
      Symbol Synonym
      EndoGIGScE6
      Name Synonyms
      Secondary FlyBase IDs
        References (1)