FB2025_01 , released February 20, 2025
Allele: Dmel\Desat1UAS.cKa
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General Information
Symbol
Dmel\Desat1UAS.cKa
Species
D. melanogaster
Name
Saccharomyces cerevisiae UAS construct a of Kohler
FlyBase ID
FBal0256996
Feature type
allele
Associated gene
Dmel\Desat1
Associated Insertion(s)
Carried in Construct
P{UAS-Desat1.K}
Key Links
Transgenic product class
wild_type
(Köhler et al., 2009)
Mutagen
Nature of the Allele
Transgenic product class
wild_type
(Köhler et al., 2009)
Mutagen
in vitro construct
(Köhler et al., 2009)
Progenitor genotype
Carried in construct
P{UAS-Desat1.K}
Cytology
Description

UAS regulatory sequences drive expression of Desat1.

(Köhler et al., 2009)
Allele components
Component
Use(s)
Regulatory region(s)
UAS
Encoded product / tool
Desat1
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 1 )
      Disease
      Interaction
      References
      ameliorates  non-syndromic X-linked intellectual disability 63
      modeled by Acsl05847, AcslKO
      (Huang et al., 2016)
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Overexpression of desat1Scer\UAS.cKa under the control of Scer\GAL4da.G32 leads to lethality.

      Overexpression of desat1Scer\UAS.cKa under the control of Scer\GAL4Act5C.PI results in lethality. Few escapers hatch, albeit with developmental delay of 3-4 days leading to animals with reduced body size that die soon after hatching.

      When desat1Scer\UAS.cKa is overexpressed using the fat body specific driver Scer\GAL4ppl.PP, flies develop normally and hatch with the expected ration.

      (Köhler et al., 2009)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Partially rescues

      Desat1UAS.cKa/Scer\GAL4ppl.PP partially rescues Desat111A

      (Köhler et al., 2009)
      Comments

      Driving the expression of desat1Scer\UAS.cKa using Scer\GAL4ppl.PP results in a partial rescue of the desat1unspecified mutant lethality.

      (Köhler et al., 2009)
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (4)
      Reported As
      Symbol Synonym
      Desat1Scer\UAS.cKa
      Desat1UAS.cKa
      desat1Scer\UAS.cKa
      Name Synonyms
      Saccharomyces cerevisiae UAS construct a of Kohler
      Secondary FlyBase IDs
        References (2)