FlyBase Allele Report: Dmel\hpo[HMS00006]

General Information

Symbol

Dmel\hpo^HMS00006

Species

D. melanogaster

Name

FlyBase ID

FBal0257055

Feature type

allele

Associated gene

Dmel\hpo

Associated Insertion(s)

Carried in Construct

P{TRiP.HMS00006}

Also Known As

UAS-hpo^RNAi, hpo RNAi, HMS00006, UAS-Hpo-RNAi, hpo-RNAi, hpo-IR

Key Links

Genomic Maps

JBrowse

Transgenic product class

RNAi_reagent

(Ni et al., 2010.12.1)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

RNAi_reagent

(Ni et al., 2010.12.1)

Mutagen

in vitro construct

(Ni et al., 2010.12.1)

Progenitor genotype

Carried in construct

P{TRiP.HMS00006}

Cytology

Description

UAS regulatory sequences drive expression of a short inverted repeat.

(Ni et al., 2010.12.1)

Allele components

Component

Use(s)

Regulatory region(s)

UAS

binary expression system - regulatory region

Encoded product / tool

dsRNA-HMS00006

Also carries

loxP

recombinase target site

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

female semi-sterile, with Scer\GAL4^{VP16.nanos.UTR}, Scer\GAL4^VP16.otu, Scer\GAL4^nanos.PG

(Sopko et al., 2014)

increased cell number, with Scer\GAL4^NP5130, Scer\GAL80^ts.αTub84B

(Kwon et al., 2013)

increased cell number | adult stage, with Scer\GAL4^esg.PU

(Shi et al., 2023)

increased size | adult stage, with Scer\GAL4^nub.PU

(Ahmad et al., 2021)

increased size | adult stage, with Scer\GAL4^ptc.PU

(Li et al., 2024)

visible | adult stage, with Scer\GAL4^nub.PU

(Ahmad et al., 2021)

visible | adult stage, with Scer\GAL4^ptc.PU

(Li et al., 2024)

Phenotype Manifest In

adult midgut, with Scer\GAL4^esg.PU

(Shi et al., 2023)

intestinal stem cell of posterior adult midgut epithelium, with Scer\GAL4^NP5130, Scer\GAL80^ts.αTub84B

(Kwon et al., 2013)

wing, with Scer\GAL4^nub.PU

(Ahmad et al., 2021)

wing, with Scer\GAL4^ptc.PU

(Li et al., 2024)

Detailed Description

Statement

Reference

The expression of hpo^HMS00006 under the control of Scer\GAL4^nub.PU leads to a large wing.

(Ahmad et al., 2021)

Females heterozygous for hpo^HMS00006 and MTD-Gal4 (consists of Scer\GAL4^{otu.T:Hsim\VP16}, Scer\GAL4^nos.PG and Scer\GAL4^{nos.UTR.T:Hsim\VP16}) crossed to hpo^HMS00006 males results in: 50% hatching; non-maternal effect.

(Sopko et al., 2014)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhanced by

Statement

Reference

Scer\GAL4^NP5130, Scer\GAL80^ts.αTub84B, hpo^HMS00006 has increased cell number phenotype, enhanceable by Leash^HMS01137, Scer\GAL4^NP5130, Scer\GAL80^ts.αTub84B

(Kwon et al., 2013)

Suppressed by

Statement

Reference

Scer\GAL4^nub.PU, hpo^HMS00006 has increased size | adult stage phenotype, suppressible by Scer\GAL4^nub.PU/syd^GLC01419

(Ahmad et al., 2021)

Scer\GAL4^nub.PU, hpo^HMS00006 has visible | adult stage phenotype, suppressible by Scer\GAL4^nub.PU/syd^GLC01419

(Ahmad et al., 2021)

Scer\GAL4^nub.PU, hpo^HMS00006 has visible | adult stage phenotype, suppressible by Df(3L)syd^A2/+

(Ahmad et al., 2021)

Scer\GAL4^nub.PU, hpo^HMS00006 has visible | adult stage phenotype, suppressible by syd[+]/syd^PL00426

(Ahmad et al., 2021)

Scer\GAL4^nub.PU, hpo^HMS00006 has increased size | adult stage phenotype, suppressible by Df(3L)syd^A2/+

(Ahmad et al., 2021)

Scer\GAL4^nub.PU, hpo^HMS00006 has increased size | adult stage phenotype, suppressible by syd[+]/syd^PL00426

(Ahmad et al., 2021)

NOT Enhancer of

Statement

Reference

hpo^HMS00006, Scer\GAL4^wor.PA is a non-enhancer of increased occurrence of cell division | larval stage phenotype of N^HMS00001, Scer\GAL4^wor.PA

(Sood et al., 2022)

Scer\GAL4^repo.PU/hpo^HMS00006 is a non-enhancer of increased size | larval stage phenotype of Scer\GAL4^repo.PU, kon^{UAS.Tag:HA,Tag:SS(wg)}

(Harrison et al., 2021)

Scer\GAL4^elav.PU/hpo^HMS00006 is a non-enhancer of increased size | larval stage phenotype of Scer\GAL4^elav.PU, kon^{UAS.Tag:HA,Tag:SS(wg)}

(Harrison et al., 2021)

Suppressor of

Statement

Reference

hpo^HMS00006/Scer\GAL4^ptc.PU is a suppressor of decreased size | adult stage phenotype of Scer\GAL4^ptc.PU, TER94^{AA.UAS.cLa.Tag:V5}

(Li et al., 2024)

Scer\GAL4^nub.PU/hpo^HMS00006 is a suppressor of decreased size | adult stage phenotype of Scer\GAL4^nub.PU, syd^GLC01419

(Ahmad et al., 2021)

Scer\GAL4^nub.PU/hpo^HMS00006 is a suppressor of visible | adult stage phenotype of Scer\GAL4^nub.PU, syd^GLC01419

(Ahmad et al., 2021)

Scer\GAL4^en.PU/hpo^HMS00006 is a suppressor | partially of increased cell death | larval stage phenotype of Scer\GAL4^en.PU, mir-285^{UAS.DsRed(Unk)}

(Li et al., 2017)

NOT Suppressor of

Statement

Reference

hpo^HMS00006, Scer\GAL4^wor.PA is a non-suppressor of increased occurrence of cell division | larval stage phenotype of N^HMS00001, Scer\GAL4^wor.PA

(Sood et al., 2022)

Scer\GAL4^repo.PU/hpo^HMS00006 is a non-suppressor of increased size | larval stage phenotype of Scer\GAL4^repo.PU, kon^{UAS.Tag:HA,Tag:SS(wg)}

(Harrison et al., 2021)

Scer\GAL4^elav.PU/hpo^HMS00006 is a non-suppressor of increased size | larval stage phenotype of Scer\GAL4^elav.PU, kon^{UAS.Tag:HA,Tag:SS(wg)}

(Harrison et al., 2021)

Phenotype Manifest In

Suppressed by

Statement

Reference

Scer\GAL4^nub.PU, hpo^HMS00006 has wing phenotype, suppressible | partially by Scer\GAL4^nub.PU/syd^GLC01419

(Ahmad et al., 2021)

Scer\GAL4^nub.PU, hpo^HMS00006 has wing phenotype, suppressible by Df(3L)syd^A2/+

(Ahmad et al., 2021)

Scer\GAL4^nub.PU, hpo^HMS00006 has wing phenotype, suppressible by syd[+]/syd^PL00426

(Ahmad et al., 2021)

Scer\GAL4^NP5130, Scer\GAL80^ts.αTub84B, hpo^HMS00006 has intestinal stem cell of posterior adult midgut epithelium phenotype, suppressible by Leash^HMS01137, Scer\GAL4^NP5130, Scer\GAL80^ts.αTub84B

(Kwon et al., 2013)

NOT Enhancer of

Statement

Reference

hpo^HMS00006, Scer\GAL4^wor.PA is a non-enhancer of larval neuroblast phenotype of N^HMS00001, Scer\GAL4^wor.PA

(Sood et al., 2022)

hpo^HMS00006, Scer\GAL4^wor.PA is a non-enhancer of larval central brain phenotype of N^HMS00001, Scer\GAL4^wor.PA

(Sood et al., 2022)

Scer\GAL4^repo.PU/hpo^HMS00006 is a non-enhancer of larval ventral nerve cord phenotype of Scer\GAL4^repo.PU, kon^{UAS.Tag:HA,Tag:SS(wg)}

(Harrison et al., 2021)

Scer\GAL4^elav.PU/hpo^HMS00006 is a non-enhancer of larval ventral nerve cord phenotype of Scer\GAL4^elav.PU, kon^{UAS.Tag:HA,Tag:SS(wg)}

(Harrison et al., 2021)

Suppressor of

Statement

Reference

hpo^HMS00006/Scer\GAL4^ptc.PU is a suppressor of wing phenotype of Scer\GAL4^ptc.PU, TER94^{AA.UAS.cLa.Tag:V5}

(Li et al., 2024)

Scer\GAL4^org-1.HN39/hpo^HMS00006 is a suppressor | partially of adult heart ventral longitudinal muscle cell | P-stage phenotype of Scer\GAL4^org-1.HN39, twi^HMJ03122

(Rose et al., 2022)

Scer\GAL4^org-1.HN39/hpo^HMS00006 is a suppressor | partially of adult heart ventral longitudinal muscle cell | P-stage phenotype of Scer\GAL4^org-1.HN39, htl^HMS01437

(Rose et al., 2022)

Scer\GAL4^nub.PU/hpo^HMS00006 is a suppressor | partially of wing phenotype of Scer\GAL4^nub.PU, syd^GLC01419

(Ahmad et al., 2021)

Scer\GAL4^en.PU/hpo^HMS00006 is a suppressor | partially of wing disc phenotype of Scer\GAL4^en.PU, mir-285^{UAS.DsRed(Unk)}

(Li et al., 2017)

NOT Suppressor of

Statement

Reference

hpo^HMS00006, Scer\GAL4^wor.PA is a non-suppressor of larval neuroblast phenotype of N^HMS00001, Scer\GAL4^wor.PA

(Sood et al., 2022)

hpo^HMS00006, Scer\GAL4^wor.PA is a non-suppressor of larval central brain phenotype of N^HMS00001, Scer\GAL4^wor.PA

(Sood et al., 2022)

Scer\GAL4^repo.PU/hpo^HMS00006 is a non-suppressor of larval ventral nerve cord phenotype of Scer\GAL4^repo.PU, kon^{UAS.Tag:HA,Tag:SS(wg)}

(Harrison et al., 2021)

Scer\GAL4^elav.PU/hpo^HMS00006 is a non-suppressor of larval ventral nerve cord phenotype of Scer\GAL4^elav.PU, kon^{UAS.Tag:HA,Tag:SS(wg)}

(Harrison et al., 2021)

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (2)

Bloomington

33614

y¹ v¹; P{TRiP.HMS00006}attP2

NIG-Fly

HMS00006

y¹ v¹; P{TRiP.HMS00006}attP2

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (1)

Reported As

Symbol Synonym

hpo^HMS00006

(Forest et al., 2018, Neisch et al., 2017)

Name Synonyms

Secondary FlyBase IDs

References (24)

Report Sections

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