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General Information
Symbol
Dmel\Akt1HMS00007
Species
D. melanogaster
Name
FlyBase ID
FBal0257056
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Also Known As
HMS00007, UAS-Akt-RNAi
Allele class
Nature of the Allele
Allele class
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Carried in construct
Cytology
Nature of the lesion
Statement
Reference

UAS regulatory sequences drive expression of a short inverted repeat.

Allele components
Product class / Tool use(s)
Encoded product / tool
Associated Sequence Features
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 1 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

The expression of Akt1HMS00007 under the control of Scer\GAL4nos.PG leads to germline degeneration in the germarium.

Females heterozygous for Akt1HMS00007 and MTD-Gal4 (consists of Scer\GAL4otu.T:Hsim\VP16, Scer\GAL4nos.PG and Scer\GAL4nos.UTR.T:Hsim\VP16) crossed to Akt1HMS00007 males results in: no eggs; egg/embryonic phenotype: no vitellogenic egg chambers; oogenesis defect.

Scer\GAL4nos.UTR.T:Hsim\VP16-mediated expression of Akt1HMS00007 results in a block to oogenesis with females containing extremely small ovaries.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Phenotype Manifest In
Additional Comments
Genetic Interactions
Statement
Reference

The co-expression of Akt1HMS00007 suppresses the increased midgut cell size resulting from the expression of Atg9HMS01246 under the control of Scer\GAL4Myo31DF-NP0001.

Co-expression of Tsc1GL00012, but not Nprl2dsRNA.shRNA.Scer\UAS.P\T or Nprl3dsRNA.shRNA.Scer\UAS.P\T, rescues the small ovary phenotype resulting from Scer\GAL4nos.UTR.T:Hsim\VP16-mediated expression of Akt1HMS00007.

Co-expression of Akt1HMS00007 suppresses the increase in the number of type II neuroblasts which is seen in the central brain of animals expressing NScer\UAS.T:SV5\V5,T:Zzzz\His6 under the control of Scer\GAL4insc-Mz1407.

Expression of Akt1HMS00007 dramatically suppresses the dendrite pruning defects seen in ddaC neurons expressing lin19GD9650 under the control of Scer\GAL4ppk.PG at 16 hours after pupariation.

Xenogenetic Interactions
Statement
Reference

The eye degeneration phenotype characteristic for adult flies expressing Hsap\CHMP2BIntron5.UAS under the control of Scer\GAL4GMR.PU is strongly enhanced by co-expression of Akt1HMS00007.

Complementation and Rescue Data
Comments
Images (0)
Mutant
Wild-type
Stocks (1)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (2)
Reported As
Symbol Synonym
Akt1HMS00007
Name Synonyms
Secondary FlyBase IDs
    References (15)