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General Information
Symbol
Dmel\dppHMS00011
Species
D. melanogaster
Name
FlyBase ID
FBal0257059
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Also Known As
UAS-dppRNAi
Allele class
Nature of the Allele
Allele class
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Carried in construct
Cytology
Nature of the lesion
Statement
Reference

UAS regulatory sequences drive expression of a short inverted repeat.

Allele components
Product class / Tool use(s)
Encoded product / tool
Associated Sequence Features
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

The adulthood-only expression of dppHMS00011 under the control of Scer\GAL4esg.PU (in combination with Gal80[ts], for temporal regulation of expression) leads to significant decreases in the relative size of secondary cell nuclei, as compared to the neighboring main cell nuclei; this effect is both cell-autonomous and non-cell autonomous. The Scer\GAL4esg.PU-driven expression also leads to a significant decrease in the number of non-acidic secretory vesicles, but not of acidic secretory vesicles, as compared to controls. Adulthood-only expression under the combined control of Scer\GAL4dsx.KI and Gal80[ts] leads to a small but significant increase the size of the largest multivesicular body/lysosome and leads to a small but significant increase in the number of non-acidic, but not of acidic, secretory vesicles within accessory gland secondary cells, as compared to controls; this is associated with a severe decrease in the secretion of (CD63-positive) exosomes into the accessory gland lumen.

The adulthood-only expression of dppHMS00011 under the combined control of Scer\GAL4spi-NP0261 and Gal80[ts] results in both virgin and mated males showing a significant increase in the number of dense core granule compartments within accessory gland secondary cells, as compared to matched controls.

Germaria in flies expressing dppHMS00011 under the control of Scer\GAL4C587 exhibit fewer cystoblasts, but no significant difference in germline stem cell number, as compared to controls.

Scer\GAL4da.Switch.PT dppHMS00011 adults, fed with RU486 to activate expression, show reduced lifespan compared to controls.

Down-regulation of dpp in Pdf-positive neurons, through expression of dppHMS00011 under the control of Scer\GAL4P2.4.Pdf induces strong locomotor arrhythmicity. Expression of dppHMS00011 under the control of Scer\GAL4tim.PE and suppressed in Pdf-positive cells through the presence of Scer\GAL80Pdf.PS results in some rescue of the arrhythmic phenotype, with arrhythmicity found in approximately 75-80% of flies.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Enhancer of
Statement
Reference
Phenotype Manifest In
Enhancer of
Additional Comments
Genetic Interactions
Statement
Reference

Expressing dppHMS00011 enhances the wing hinge phenotype seen when hng1KK103642 is expressed under the control of Scer\GAL4Bx-MS1096.

Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Comments
Images (0)
Mutant
Wild-type
Stocks (1)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (2)
Reported As
Symbol Synonym
dppBL33618
dppHMS00011
Name Synonyms
Secondary FlyBase IDs
    References (10)