FlyBase Allele Report: Dmel\Glyp[HMS00032]

General Information

Symbol

Dmel\Glyp^HMS00032

Species

D. melanogaster

Name

FlyBase ID

FBal0257075

Feature type

allele

Associated gene

Dmel\Glyp

Associated Insertion(s)

Carried in Construct

P{TRiP.HMS00032}

Also Known As

GlyP-RNAi

Key Links

Genomic Maps

JBrowse

Transgenic product class

RNAi_reagent

(Ni et al., 2010.12.1)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

RNAi_reagent

(Ni et al., 2010.12.1)

Mutagen

in vitro construct

(Ni et al., 2010.12.1)

Progenitor genotype

Carried in construct

P{TRiP.HMS00032}

Cytology

Description

UAS regulatory sequences drive expression of a short inverted repeat.

(Ni et al., 2010.12.1)

Allele components

Component

Use(s)

Regulatory region(s)

UAS

binary expression system - regulatory region

Encoded product / tool

dsRNA-HMS00032

Also carries

loxP

recombinase target site

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal mitotic cell cycle | embryonic stage | parental effect, with Scer\GAL4^{VP16.mat.αTub67C}

(Avilés-Pagán et al., 2020)

long lived | RU486 conditional, with Scer\GAL4^{αTub84B.Switch.PK}

(Bai et al., 2013)

majority die during larval stage, with Scer\GAL4^Mef2.PR

(Yamada et al., 2019)

majority die during larval stage, with Scer\GAL4^Mef2.PR, Scer\GAL4^elav.PLu

(Yamada et al., 2019)

majority die during larval stage, with Scer\GAL4^αTub84B.PL

(Yamada et al., 2019)

partially lethal, with Scer\GAL4^elav.PLu

(Yamada et al., 2019)

partially lethal, with Scer\GAL4^Mef2.PR

(Yamada et al., 2019)

partially lethal, with Scer\GAL4^Mef2.PR, Scer\GAL4^elav.PLu

(Yamada et al., 2019)

partially lethal, with Scer\GAL4^αTub84B.PL

(Yamada et al., 2019)

some die during larval stage, with Scer\GAL4^elav.PLu

(Yamada et al., 2019)

viable, with Scer\GAL4^Cg.PA

(Yamada et al., 2019)

viable, with Scer\GAL4^repo

(Yamada et al., 2019)

Phenotype Manifest In

Detailed Description

Statement

Reference

Embryos derived from adults expressing GlyP^HMS00032 under the control of Scer\GAL4^{VP16.mat.αTub67C} (in combination with a Dicer-2 transgene to enhance RNAi efficiency) exhibit mitotic abnormalities.

(Avilés-Pagán et al., 2020)

Scer\GAL4^{αTub84B.Switch.PK} GlyP^HMS00032 adults, fed with RU486 to activate expression, show extended lifespan compared to controls.

(Bai et al., 2013)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Phenotype Manifest In

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (2)

Bloomington

33634

y¹ v¹; P{TRiP.HMS00032}attP2

NIG-Fly

HMS00032

y¹ v¹; P{TRiP.HMS00032}attP2

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

GlyP^HMS00032

Glyp^HMS00032

Name Synonyms

Secondary FlyBase IDs

References (6)

Report Sections

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