FlyBase Allele Report: Dmel\Stat92E[HMS00035]

General Information

Symbol

Dmel\Stat92E^HMS00035

Species

D. melanogaster

Name

FlyBase ID

FBal0257078

Feature type

allele

Associated gene

Dmel\Stat92E

Associated Insertion(s)

Carried in Construct

P{TRiP.HMS00035}

Also Known As

UAS-Stat92E^RNAi, stat92e RNAi, UAS-Stat92E RNAi, UAS-Stat92E-RNAi

Key Links

Genomic Maps

JBrowse

Transgenic product class

RNAi_reagent

(Ni et al., 2010.12.1)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

RNAi_reagent

(Ni et al., 2010.12.1)

Mutagen

in vitro construct

(Ni et al., 2010.12.1)

Progenitor genotype

Carried in construct

P{TRiP.HMS00035}

Cytology

Description

UAS regulatory sequences drive expression of a short inverted repeat.

(Ni et al., 2010.12.1)

Allele components

Component

Use(s)

Regulatory region(s)

UAS

binary expression system - regulatory region

Encoded product / tool

dsRNA-HMS00035

Also carries

loxP

recombinase target site

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 1 )

Disease

Interaction

References

ameliorates cancer

modeled by yki^{S111A.S168A.S250A.UAS.Tag:V5}

(Ding et al., 2021)

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

Phenotype Manifest In

germarium, with Scer\GAL4^C587

(Liu et al., 2015)

male germline stem cell, with Scer\GAL4^nanos.PU

(Tarayrah et al., 2015)

wing, with Scer\GAL4^VGAT.PF

(Rajan and Perrimon, 2012)

wing disc | third instar larval stage, with Scer\GAL4^en-e16E

(Sun et al., 2020)

wing disc posterior compartment | third instar larval stage, with Scer\GAL4^en-e16E

(Recasens-Alvarez et al., 2017)

Detailed Description

Statement

Reference

Expression of Stat92E^HMS00035 under the control of Scer\GAL4^en-e16E leads to increased cell death in third instar larval wing discs.

(Sun et al., 2020)

The expression of Stat92E^HMS00035 under the control of Scer\GAL4^en-e16E (and Dicer-2, for more efficient RNAi) leads to a severe size reduction of the third instar larval wing disc posterior compartment, as compared to controls.

(Recasens-Alvarez et al., 2017)

Expression of Stat92E^HMS00035 under the control of Scer\GAL4^C587 results in germaria with fewer spectrosome-containing cells, as compared to controls.

(Liu et al., 2015)

Stat92E^HMS00035 driven by Scer\GAL4^nos.PU leads to displaced (detached from the hub) germline stem cells and a premature differentiation phenotype (differentiated spermatogonial cysts directly contacting hub cells) in testes.

(Tarayrah et al., 2015)

Expression of Stat92E^HMS00035 under the control of Scer\GAL4^Cg.PA has no effect on triacylglycerol levels in adults.

Expression of Stat92E^HMS00035 under the control of Scer\GAL4^dome-PG14 results in lethality at 25[o]C. At 18[o]C, adult flies emerge but they are significantly smaller than normal.

Adults expressing Stat92E^HMS00035 under the control of Scer\GAL4^dome-PG14 and shifted to 29[o]C for 7 days show a significant reduction in triacylglycerol levels compared to controls.

Expression of Stat92E^HMS00035 under the control of Scer\GAL4^VGAT.PF results in small, slim flies, as quantified by a reduction in wing area.

(Rajan and Perrimon, 2012)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhancer of

Statement

Reference

Stat92E^HMS00035/Scer\GAL4^R42A07.-FRT is an enhancer of decreased size | adult stage | somatic clone phenotype of Ecol\lexA^DBD.R85E08, Hsap\RELA^AD.Hsp70, rpr^{13xlexAop.cHa}

(Harris et al., 2020)

Stat92E^HMS00035/Scer\GAL4^R42A07.-FRT is an enhancer of visible | adult stage | somatic clone phenotype of Ecol\lexA^DBD.R85E08, Hsap\RELA^AD.Hsp70, rpr^{13xlexAop.cHa}

(Harris et al., 2020)

Suppressor of

Statement

Reference

Stat92E^HMS00035, Scer\GAL4^Bx-MS1096 is a suppressor of increased size | larval stage phenotype of Nkap^GD11807, Scer\GAL4^Bx-MS1096

(Guo et al., 2024)

Stat92E^HMS00035, Scer\GAL4^phtm.PO is a suppressor | partially of abnormal developmental rate phenotype of Pvr^{λ.UASp.Tag:MYC}, Scer\GAL4^phtm.PO

(Pan and O'Connor, 2021)

Stat92E^HMS00035, Scer\GAL4^phtm.PO is a suppressor | partially of abnormal developmental rate phenotype of Alk^{act.UAS.Tag:HA}, Scer\GAL4^phtm.PO

(Pan and O'Connor, 2021)

NOT Suppressor of

Statement

Reference

Stat92E^HMS00035/Scer\GAL4^hh.PU is a non-suppressor of increased cell death | larval stage phenotype of Scer\GAL4^hh.PU, Spyo\Cas9^UAS.P2, wg^{UAS.wg+intergenic-1.pCFD6}

(Ewen-Campen and Perrimon, 2024)

Phenotype Manifest In

Enhancer of

Statement

Reference

Stat92E^HMS00035/Scer\GAL4^R42A07.-FRT is an enhancer of wing | somatic clone phenotype of Ecol\lexA^DBD.R85E08, Hsap\RELA^AD.Hsp70, rpr^{13xlexAop.cHa}

(Harris et al., 2020)

Suppressor of

Statement

Reference

Stat92E^HMS00035, Scer\GAL4^Bx-MS1096 is a suppressor of wing disc | larval stage phenotype of Nkap^GD11807, Scer\GAL4^Bx-MS1096

(Guo et al., 2024)

Stat92E^HMS00035/Scer\GAL4^C587 is a suppressor of germarium phenotype of Scer\GAL4^C587, ci^GD1403

(Liu et al., 2015)

Stat92E^HMS00035/Scer\GAL4^C587 is a suppressor of spectrosome phenotype of Scer\GAL4^C587, ci^GD1403

(Liu et al., 2015)

NOT Suppressor of

Statement

Reference

Stat92E^HMS00035/Scer\GAL4^hh.PU is a non-suppressor of wing disc posterior compartment | larval stage phenotype of Scer\GAL4^hh.PU, Spyo\Cas9^UAS.P2, wg^{UAS.wg+intergenic-1.pCFD6}

(Ewen-Campen and Perrimon, 2024)

Additional Comments

Genetic Interactions

Statement

Reference

Co-expression of Stat92E^HMS00035 suppresses the increased number of spectrosomes in the germaria of flies expressing smo^JF02363 under the control of Scer\GAL4^C587.

(Liu et al., 2015)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (1)

Bloomington

33637

y¹ v¹; P{TRiP.HMS00035}attP2

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (3)

Reported As

Symbol Synonym

Stat92E^HMS00035

Stat92E^RNAi

(Bhaskar et al., 2022)

stat92e^BL33637

(Liu et al., 2015)

Name Synonyms

Secondary FlyBase IDs

References (28)

Report Sections

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