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General Information
Symbol
Dmel\mysHMS00043
Species
D. melanogaster
Name
FlyBase ID
FBal0257083
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Also Known As
HMS00043, UAS-mys RNAi
Allele class
Nature of the Allele
Allele class
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Carried in construct
Cytology
Nature of the lesion
Statement
Reference

UAS regulatory sequences drive expression of a short inverted repeat.

Allele components
Product class / Tool use(s)
Encoded product / tool
Associated Sequence Features
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

Adult flies expressing mysHMS00043 under the control of Scer\GAL4Dot.PK display nephrocyte functional defects (measured by uptake assays) and reduced adult lifespan relative to controls.

Expression of mysHMS00043 under the control of Scer\GAL4repo leads to abnormal elongation of ventral nerve cord in third instar larvae.

Scer\GAL4Mef2.PR-mediated expression of mysHMS00043, induced at the end of the first larval instar stage using the Scer\GAL80 system, results in muscle attachment defects.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Phenotype Manifest In
Additional Comments
Genetic Interactions
Statement
Reference

The neural invasion phenotype (neural cells from the brain invade adjacent peripheral structures such as imaginal discs) observed in AdamTS-Arnwy1/AdamTS-Arnwy2 mutant third instar larvae is partially suppressed by combination expression of mysHMS00043 if driven by Scer\GAL4repo but not if driven by Scer\GAL4elav.PU combined with Scer\GAL80repo.PL.

Flies co-expressing mysHMS00043 and DlScer\UAS.cDa under the control of Scer\GAL4ey.PU show a high frequency of primary eye tumours and a low frequency of secondary tumours.

Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Comments
Images (0)
Mutant
Wild-type
Stocks (1)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (4)
Reported As
Symbol Synonym
Int βRNAi
mysHMS00043
β IntegrinRNAi
Name Synonyms
Secondary FlyBase IDs
    References (14)