FlyBase Allele Report: Dmel\mys[HMS00043]

General Information

Symbol

Dmel\mys^HMS00043

Species

D. melanogaster

Name

FlyBase ID

FBal0257083

Feature type

allele

Associated gene

Dmel\mys

Associated Insertion(s)

Carried in Construct

P{TRiP.HMS00043}

Also Known As

UAS-mys RNAi, HMS00043

Key Links

Genomic Maps

JBrowse

Transgenic product class

RNAi_reagent

(Ni et al., 2010.12.1)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

RNAi_reagent

(Ni et al., 2010.12.1)

Mutagen

in vitro construct

(Ni et al., 2010.12.1)

Progenitor genotype

Carried in construct

P{TRiP.HMS00043}

Cytology

Description

UAS regulatory sequences drive expression of a short inverted repeat.

(Ni et al., 2010.12.1)

Allele components

Component

Use(s)

Regulatory region(s)

UAS

binary expression system - regulatory region

Encoded product / tool

dsRNA-HMS00043

Also carries

loxP

recombinase target site

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 1 )

Disease

Evidence

References

model of gastric diffuse adenocarcinoma

CEA with Hsap\CDH1^R749W.UAS

(Figueiredo et al., 2022)

CEA with Hsap\CDH1^WT.UAS

(Figueiredo et al., 2022)

Modifiers Based on Experimental Evidence ( 1 )

Disease

Interaction

References

exacerbates cancer

modeled by Delta^UAS.cDa

(Zhai et al., 2012)

ameliorates Huntington's disease

modeled by Hsap\HTT^{128Q.1-231.UAS}

(Hernandez et al., 2023)

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

Phenotype Manifest In

Detailed Description

Statement

Reference

Adult flies expressing mys^HMS00043 under the control of Scer\GAL4^Dot.PK display nephrocyte functional defects (measured by uptake assays) and reduced adult lifespan relative to controls.

(Fu et al., 2017)

Expression of mys^HMS00043 under the control of Scer\GAL4^repo leads to abnormal elongation of ventral nerve cord in third instar larvae.

(Skeath et al., 2017)

Scer\GAL4^Mef2.PR-mediated expression of mys^HMS00043, induced at the end of the first larval instar stage using the Scer\GAL80 system, results in muscle attachment defects.

(Liu et al., 2013)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressor of

Statement

Reference

mys^HMS00043, Scer\GAL4^repo is a suppressor of decreased rate of adult locomotory behavior phenotype of Hsap\HTT^{128Q.1-231.UAS}, Scer\GAL4^repo

(Hernandez et al., 2023)

mys^HMS00043, Scer\GAL4^GMR.PU is a suppressor | partially of visible | adult stage phenotype of Hsap\CDH1^R749W.UAS, Scer\GAL4^GMR.PU

(Figueiredo et al., 2022)

mys^HMS00043, Scer\GAL4^GMR.PU is a suppressor | partially of increased cell death | adult stage phenotype of Hsap\CDH1^R749W.UAS, Scer\GAL4^GMR.PU

(Figueiredo et al., 2022)

mys^HMS00043, Scer\GAL4^GMR.PU is a suppressor | partially of visible | adult stage phenotype of Hsap\CDH1^WT.UAS, Scer\GAL4^GMR.PU

(Figueiredo et al., 2022)

mys^HMS00043, Scer\GAL4^GMR.PU is a suppressor | partially of increased cell death | adult stage phenotype of Hsap\CDH1^WT.UAS, Scer\GAL4^GMR.PU

(Figueiredo et al., 2022)

Scer\GAL4^repo/mys^HMS00043 is a suppressor | partially of abnormal neuroanatomy | third instar larval stage phenotype of AdamTS-A^rnwy2/AdamTS-A^rnwy1

(Skeath et al., 2017)

NOT Suppressor of

Statement

Reference

Scer\GAL4^elav.PU, Scer\GAL80^repo.PL, mys^HMS00043 is a non-suppressor of abnormal neuroanatomy | third instar larval stage phenotype of AdamTS-A^rnwy2/AdamTS-A^rnwy1

(Skeath et al., 2017)

Other

Statement

Reference

Delta^UAS.cDa, Scer\GAL4^ey.PU, mys^HMS00043 has neoplasia phenotype

(Zhai et al., 2012)

Phenotype Manifest In

Suppressor of

Statement

Reference

mys^HMS00043, Scer\GAL4^GMR.PU is a suppressor | partially of eye phenotype of Hsap\CDH1^R749W.UAS, Scer\GAL4^GMR.PU

(Figueiredo et al., 2022)

mys^HMS00043, Scer\GAL4^GMR.PU is a suppressor | partially of eye phenotype of Hsap\CDH1^WT.UAS, Scer\GAL4^GMR.PU

(Figueiredo et al., 2022)

Scer\GAL4^repo/mys^HMS00043 is a suppressor | partially of larval brain | third instar larval stage phenotype of AdamTS-A^rnwy2/AdamTS-A^rnwy1

(Skeath et al., 2017)

NOT Suppressor of

Statement

Reference

Scer\GAL4^elav.PU, Scer\GAL80^repo.PL, mys^HMS00043 is a non-suppressor of larval brain | third instar larval stage phenotype of AdamTS-A^rnwy2/AdamTS-A^rnwy1

(Skeath et al., 2017)

Other

Statement

Reference

Delta^UAS.cDa, Scer\GAL4^ey.PU, mys^HMS00043 has eye phenotype

(Zhai et al., 2012)

Additional Comments

Genetic Interactions

Statement

Reference

The neural invasion phenotype (neural cells from the brain invade adjacent peripheral structures such as imaginal discs) observed in AdamTS-A^rnwy1/AdamTS-A^rnwy2 mutant third instar larvae is partially suppressed by combination expression of mys^HMS00043 if driven by Scer\GAL4^repo but not if driven by Scer\GAL4^elav.PU combined with Scer\GAL80^repo.PL.

(Skeath et al., 2017)

Flies co-expressing mys^HMS00043 and Dl^Scer\UAS.cDa under the control of Scer\GAL4^ey.PU show a high frequency of primary eye tumours and a low frequency of secondary tumours.

(Zhai et al., 2012)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (2)

Bloomington

33642

y¹ v¹; P{TRiP.HMS00043}attP2

NIG-Fly

HMS00043

y¹ v¹; P{TRiP.HMS00043}attP2

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (6)

Reported As

Symbol Synonym

Int β^RNAi

(Kim et al., 2018)

mys^HMS00043

mys^IR

(Qi et al., 2023)

mys^S00043RNAi

(Hartman et al., 2015)

β Integrin^RNAi

(Cho et al., 2018)

βPS^RNAi

(Zhai et al., 2012)

Name Synonyms

Secondary FlyBase IDs

References (28)

Report Sections

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