FlyBase Allele Report: Dmel\Rel[HMS00070]

General Information

Symbol

Dmel\Rel^HMS00070

Species

D. melanogaster

Name

FlyBase ID

FBal0257102

Feature type

allele

Associated gene

Dmel\Rel

Associated Insertion(s)

Carried in Construct

P{TRiP.HMS00070}

Also Known As

UAS-Rel RNAi, UAS-Rel-RNAi, UAS-relish-IR, UAS-Rel^RNAi

Key Links

Genomic Maps

JBrowse

Transgenic product class

RNAi_reagent

(Ni et al., 2010.12.1)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

RNAi_reagent

(Ni et al., 2010.12.1)

Mutagen

in vitro construct

(Ni et al., 2010.12.1)

Progenitor genotype

Carried in construct

P{TRiP.HMS00070}

Cytology

Description

UAS regulatory sequences drive expression of a short inverted repeat.

(Ni et al., 2010.12.1)

Allele components

Component

Use(s)

Regulatory region(s)

UAS

binary expression system - regulatory region

Encoded product / tool

dsRNA-HMS00070

Also carries

loxP

recombinase target site

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 1 )

Disease

Interaction

References

ameliorates epilepsy

modeled by pk^sple-1

(Nukala et al., 2023)

ameliorates Machado-Joseph disease

modeled by Hsap\ATXN3^{polyQ78.QUAS.Tag:HA}

(Li et al., 2018)

ameliorates Alzheimer's disease 1

modeled by Hsap\APP^{Aβ42.QUAS.Tag:SS(nec)}

(Li et al., 2018)

ameliorates amyotrophic lateral sclerosis type 8

modeled by Vap33^Δ166, Vap33^P58S.cRa.UAS

(Tendulkar et al., 2022)

ameliorates cancer

modeled by yki^{3SA.lexAop.Tag:Myr(Unk),GFP}

(Chen et al., 2022)

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

Phenotype Manifest In

abdominal anterior ventral multidendritic neuron vdaa, with Scer\GAL4^ppk.1.9

(Iyer et al., 2013)

larval dorsal multidendritic neuron ddaC, with Scer\GAL4^ppk.1.9

(Iyer et al., 2013)

larval multidendritic class IV neuron | third instar larval stage, with Scer\GAL4^ppk.PU

(Kwon et al., 2018)

lipid droplet | conditional, with Scer\GAL4^Myo31DF.PU

(Shianiou et al., 2023)

midgut | conditional, with Scer\GAL4^Myo31DF.PU

(Shianiou et al., 2023)

Detailed Description

Statement

Reference

Expression of Rel^HMS00070 under the control of Scer\GAL4^da.G32 does not lead to any changes in climbing ability when compared to controls.

(Lee et al., 2020)

Expressing Rel^HMS00070 under the control of Scer\GAL4^ppk.PU results in a significantly reduced number of branch points in the dendrites of class IV dendritic arborizing neurons in third instar larvae compared to wild-type controls.

(Kwon et al., 2018)

Adults expressing Rel^HMS00070 under the control of either Scer\GAL4^elav-C155 or Scer\GAL4^repo infected with ZIKV present a significantly increased viral load in the head, as compared to infected controls.

(Liu et al., 2018)

Adult flies expressing Rel^HMS00070 under the control of Scer\GAL4^Act5C.PI exhibit increased susceptibility to Coxiella burnetii: their post-infection survival rate is significantly reduced compared to controls.

(Bastos et al., 2017)

Expression of Rel^HMS00070 in C-IV neurons under the control of Scer\GAL4^ppk.1.9 results in a reduction in total dendritic length in ddaC and v'ada neurons.

(Iyer et al., 2013)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

NOT Enhancer of

Statement

Reference

Scer\GAL4^da.G32/Rel^HMS00070 is a non-enhancer of abnormal locomotor behavior | adult stage phenotype of Pink1^B9

(Lee et al., 2020)

Scer\GAL4^da.G32/Rel^HMS00070 is a non-enhancer of abnormal locomotor behavior | adult stage phenotype of park²⁵

(Lee et al., 2020)

Suppressor of

Statement

Reference

Rel^HMS00070, Scer\GAL4^repo.PU is a suppressor | partially of short lived phenotype of Scer\GAL4^repo.PU, Uuuu\Ub^{K0.UAS.6.Stop.Tag:HA}

(Blount et al., 2020)

NOT Suppressor of

Statement

Reference

Scer\GAL4^da.G32/Rel^HMS00070 is a non-suppressor of abnormal locomotor behavior | adult stage phenotype of Pink1^B9

(Lee et al., 2020)

Scer\GAL4^da.G32/Rel^HMS00070 is a non-suppressor of abnormal locomotor behavior | adult stage phenotype of park²⁵

(Lee et al., 2020)

Phenotype Manifest In

NOT Enhancer of

Statement

Reference

Scer\GAL4^da.G32/Rel^HMS00070 is a non-enhancer of flight muscle cell phenotype of Pink1^B9

(Lee et al., 2020)

Scer\GAL4^da.G32/Rel^HMS00070 is a non-enhancer of mitochondrion | adult stage phenotype of Pink1^B9

(Lee et al., 2020)

Scer\GAL4^da.G32/Rel^HMS00070 is a non-enhancer of flight muscle cell phenotype of park²⁵

(Lee et al., 2020)

Scer\GAL4^da.G32/Rel^HMS00070 is a non-enhancer of mitochondrion | adult stage phenotype of park²⁵

(Lee et al., 2020)

NOT Suppressor of

Statement

Reference

Scer\GAL4^da.G32/Rel^HMS00070 is a non-suppressor of flight muscle cell phenotype of Pink1^B9

(Lee et al., 2020)

Scer\GAL4^da.G32/Rel^HMS00070 is a non-suppressor of mitochondrion | adult stage phenotype of Pink1^B9

(Lee et al., 2020)

Scer\GAL4^da.G32/Rel^HMS00070 is a non-suppressor of flight muscle cell phenotype of park²⁵

(Lee et al., 2020)

Scer\GAL4^da.G32/Rel^HMS00070 is a non-suppressor of mitochondrion | adult stage phenotype of park²⁵

(Lee et al., 2020)

Additional Comments

Genetic Interactions

Statement

Reference

Expression of Rel^HMS00070 under the control of Scer\GAL4^da.G32 does not modify the impaired climbing ability, or the disrupted tissue or mitochondrial integrity in the flight muscles phenotype of either young park²⁵ or young Pink1^B9 mutants.

(Lee et al., 2020)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (2)

Bloomington

33661