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General Information
Symbol
Dmel\poloHMS00530
Species
D. melanogaster
Name
FlyBase ID
FBal0257219
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Allele class
Nature of the Allele
Allele class
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Carried in construct
Cytology
Nature of the lesion
Statement
Reference
UAS regulatory sequences drive expression of a short inverted repeat.
Allele components
Product class / Tool use(s)
Encoded product / tool
Associated Sequence Features
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 1 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference
poloHMS00530 driven by Scer\GAL4Appl.G1a does not significantly affect number of boutons or branches at the larval neuromuscular junction, locomotion (larval or adult) or lifespan. poloHMS00530 driven by Scer\GAL4fru-NP0021 does not affect male courtship preference. poloHMS00530 driven by Scer\GAL4GMR.PU does not affect eye development or cell cycle at the third instar larval eye disc.
Females heterozygous for poloHMS00530 and MTD-Gal4 (consists of Scer\GAL4otu.T:Hsim\VP16, Scer\GAL4nos.PG and Scer\GAL4nos.UTR.T:Hsim\VP16) crossed to poloHMS00530 males results in: no eggs; egg/embryonic phenotype: no vitellogenic egg chambers; oogenesis defect.
External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Phenotype Manifest In
Additional Comments
Genetic Interactions
Statement
Reference
Xenogenetic Interactions
Statement
Reference
Co-expression of poloHMS00530 partially suppresses the wing expansion defects, shorter lifespan, locomotion defects (larval and adult) and increases of bouton and branch number (including decreases in Ib boutons and increases in Is boutons) seen at the larval neuromuscular junction in animals with Hsap\APP695.Scer\UAS driven by Scer\GAL4Appl.G1a. Co-expression of poloHMS00530 partially suppresses the courtship defects in male flies with Hsap\APP695.Scer\UAS driven by Scer\GAL4fru-NP0021. Co-expression of poloHMS00530 partially suppresses the adult eye development defects and abnormal cell cycle re-entry at the third instar larval eye disc seen when Hsap\APP695.Scer\UAS is driven by Scer\GAL4GMR.PU. Adult-specific (reared at 17[o]C, 25[o]C after eclosion) expression of poloHMS00530 partially suppresses the decline in climbing ability seen in older flies expressing Hsap\APP695.Scer\UAS driven by Scer\GAL4Appl.G1a during adulthood. Adult-specific (reared at 17[o]C, 29[o]C after eclosion) expression of poloHMS00530 partially suppresses shortened lifespan in flies with Hsap\APP695.Scer\UAS driven by Scer\GAL4Appl.G1a during adulthood.
Complementation and Rescue Data
Comments
Images (0)
Mutant
Wild-type
Stocks (1)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (1)
Reported As
Symbol Synonym
poloHMS00530
Name Synonyms
Secondary FlyBase IDs
    References (3)