FlyBase Allele Report: Dmel\chic[HMS00550]

General Information

Symbol

Dmel\chic^HMS00550

Species

D. melanogaster

Name

FlyBase ID

FBal0257239

Feature type

allele

Associated gene

Dmel\chic

Associated Insertion(s)

Carried in Construct

P{TRiP.HMS00550}

Also Known As

chic RNAi, UAS-Chic^RNAi, UAS-chic RNAi

Key Links

Genomic Maps

JBrowse

Transgenic product class

RNAi_reagent

(Ni et al., 2010.12.1)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

RNAi_reagent

(Ni et al., 2010.12.1)

Mutagen

in vitro construct

(Ni et al., 2010.12.1)

Progenitor genotype

Carried in construct

P{TRiP.HMS00550}

Cytology

Description

UAS regulatory sequences drive expression of a short inverted repeat.

(Ni et al., 2010.12.1)

Allele components

Component

Use(s)

Regulatory region(s)

UAS

binary expression system - regulatory region

Encoded product / tool

dsRNA-HMS00550

Also carries

loxP

recombinase target site

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

Phenotype Manifest In

dendritic branch | larval stage, with Scer\GAL4^ppk.PG

(Li and Gavis, 2022)

larval multidendritic class IV neuron, with Scer\GAL4^ppk.PG

(Li and Gavis, 2022)

larval s-LNv neuron, with Scer\GAL4^P2.4.Pdf

(Liu et al., 2024)

neuron projection | larval stage, with Scer\GAL4^P2.4.Pdf

(Liu et al., 2024)

Detailed Description

Statement

Reference

Scer\GAL4^VGlut-OK371-driven expression of chic^HMS00550 results in pupal lethality.

(Wu et al., 2017)

Ectopic expression of chic^HMS00550 under the control of either of the following: Scer\GAL4^Hand.PU, Scer\GAL4^Mef2.PU and Scer\GAL4^Hk-UH3 results in lethality as flies do not eclose from their puparia.

(Kooij et al., 2016)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressed by

Statement

Reference

Scer\GAL4^ppk.PG, chic^HMS00550 has abnormal neuroanatomy | larval stage phenotype, suppressible | partially by Fmr1^HMS00248, Scer\GAL4^ppk.PG

(Li and Gavis, 2022)

Scer\GAL4^VGlut1-OK371, chic^HMS00550 has lethal - all die before end of pupal stage phenotype, suppressible by Hsap\PFN1^UAS.Tag:V5, Scer\GAL4^VGlut1-OK371

(Wu et al., 2017)

Scer\GAL4^VGlut1-OK371, chic^HMS00550 has lethal - all die before end of pupal stage phenotype, suppressible by Hsap\PFN1^{C71G.UAS.Tag:V5}, Scer\GAL4^VGlut1-OK371

(Wu et al., 2017)

Scer\GAL4^VGlut1-OK371, chic^HMS00550 has lethal - all die before end of pupal stage phenotype, suppressible by Hsap\PFN1^{M114T.UAS.Tag:V5}, Scer\GAL4^VGlut1-OK371

(Wu et al., 2017)

NOT Enhancer of

Statement

Reference

chic^HMS00550, Scer\GAL4^Ser.PGF is a non-enhancer of decreased size | adult stage phenotype of Psi^KK101882, Scer\GAL4^Ser.PGF

(Zaytseva et al., 2023)

Suppressor of

Statement

Reference

chic^HMS00550, Scer\GAL4^ppk.PG is a suppressor | partially of abnormal neuroanatomy | larval stage phenotype of Fmr1^HMS00248, Scer\GAL4^ppk.PG

(Li and Gavis, 2022)

NOT Suppressor of

Statement

Reference

chic^HMS00550, Scer\GAL4^Ser.PGF is a non-suppressor of decreased size | adult stage phenotype of Psi^KK101882, Scer\GAL4^Ser.PGF

(Zaytseva et al., 2023)

Phenotype Manifest In

Suppressed by

Statement

Reference

Scer\GAL4^ppk.PG, chic^HMS00550 has larval multidendritic class IV neuron phenotype, suppressible | partially by Fmr1^HMS00248, Scer\GAL4^ppk.PG

(Li and Gavis, 2022)

Scer\GAL4^ppk.PG, chic^HMS00550 has dendritic branch | larval stage phenotype, suppressible | partially by Fmr1^HMS00248, Scer\GAL4^ppk.PG

(Li and Gavis, 2022)

Enhancer of

Statement

Reference

Scer\GAL4^fkh.PH/chic^HMS00550 is an enhancer of embryonic/larval salivary gland | embryonic stage phenotype of smog^null

(Vishwakarma et al., 2022)

NOT Enhancer of

Statement

Reference

chic^HMS00550, Scer\GAL4^Ser.PGF is a non-enhancer of wing posterior compartment phenotype of Psi^KK101882, Scer\GAL4^Ser.PGF

(Zaytseva et al., 2023)

Suppressor of

Statement

Reference

chic^HMS00550, Scer\GAL4^ppk.PG is a suppressor | partially of larval multidendritic class IV neuron phenotype of Fmr1^HMS00248, Scer\GAL4^ppk.PG

(Li and Gavis, 2022)

chic^HMS00550, Scer\GAL4^ppk.PG is a suppressor | partially of dendritic branch | increased number | larval stage phenotype of Fmr1^HMS00248, Scer\GAL4^ppk.PG

(Li and Gavis, 2022)

NOT Suppressor of

Statement

Reference

chic^HMS00550, Scer\GAL4^Ser.PGF is a non-suppressor of wing posterior compartment phenotype of Psi^KK101882, Scer\GAL4^Ser.PGF

(Zaytseva et al., 2023)

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

The pupal lethality of animals expressing chic^HMS00550 under the control of Scer\GAL4^VGlut-OK371 can be rescued by co-expression of any of the following: Hsap\PFN1^{Scer\UAS.T:SV5\V5}, Hsap\PFN1^{C71G.Scer\UAS.T:SV5\V5} or Hsap\PFN1^{M114T.Scer\UAS.T:SV5\V5}.

(Wu et al., 2017)

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (2)

Bloomington

34523

y¹ sc^* v¹ sev²¹; P{TRiP.HMS00550}attP2

NIG-Fly

HMS00550

y¹ sc^* v¹ sev²¹; P{TRiP.HMS00550}attP2

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

chic^HMS00550

chic^RNAi

(Li and Gavis, 2022)

Name Synonyms

Secondary FlyBase IDs

References (16)

Report Sections

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