FlyBase Allele Report: Dmel\Set1[HMS00581]

General Information

Symbol

Dmel\Set1^HMS00581

Species

D. melanogaster

Name

FlyBase ID

FBal0257267

Feature type

allele

Associated gene

Dmel\Set1

Associated Insertion(s)

Carried in Construct

P{TRiP.HMS00581}

Also Known As

UAS-RNAi-Set1, Set1 RNAi

Key Links

Genomic Maps

JBrowse

Transgenic product class

RNAi_reagent

(Ni et al., 2010.12.1)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

RNAi_reagent

(Ni et al., 2010.12.1)

Mutagen

in vitro construct

(Ni et al., 2010.12.1)

Progenitor genotype

Carried in construct

P{TRiP.HMS00581}

Cytology

Description

UAS regulatory sequences drive expression of a short inverted repeat.

(Ni et al., 2010.12.1)

Allele components

Component

Use(s)

Regulatory region(s)

UAS

binary expression system - regulatory region

Encoded product / tool

dsRNA-HMS00581

Also carries

loxP

recombinase target site

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 1 )

Disease

Evidence

References

model of neurodevelopmental disorder with speech impairment and dysmorphic facies

CEC

(Kummeling et al., 2021)

Modifiers Based on Experimental Evidence ( 1 )

Disease

Interaction

References

ameliorates brain cancer

modeled by pros^JF02308

(Gaultier et al., 2022)

exacerbates amyotrophic lateral sclerosis type 10

modeled by Hsap\TARDBP^UAS.cEa

(Berson et al., 2017)

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

Phenotype Manifest In

Detailed Description

Statement

Reference

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressed by

Statement

Reference

Scer\GAL4^{VP16.nanos.UTR}, Set1^HMS00581 has abnormal cell number | spermatogenesis phenotype, suppressible | partially by Mad¹²/Mad[+]

(Vidaurre et al., 2024)

Scer\GAL4^{VP16.nanos.UTR}, Set1^HMS00581 has abnormal cell number | spermatogenesis phenotype, suppressible | partially by tkv⁴/tkv[+]

(Vidaurre et al., 2024)

Scer\GAL4^{VP16.nanos.UTR}, Set1^HMS00581 has abnormal cell number | spermatogenesis phenotype, suppressible | partially by Stat92E[+]/Stat92E⁰⁶³⁴⁶

(Vidaurre et al., 2024)

Phenotype Manifest In

Suppressed by

Statement

Reference

Scer\GAL4^{VP16.nanos.UTR}, Set1^HMS00581 has male germline stem cell phenotype, suppressible | partially by Mad¹²/Mad[+]

(Vidaurre et al., 2024)

Scer\GAL4^{VP16.nanos.UTR}, Set1^HMS00581 has male germline stem cell phenotype, suppressible | partially by tkv⁴/tkv[+]

(Vidaurre et al., 2024)

Scer\GAL4^{VP16.nanos.UTR}, Set1^HMS00581 has male germline stem cell phenotype, suppressible | partially by Stat92E[+]/Stat92E⁰⁶³⁴⁶

(Vidaurre et al., 2024)

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Rescued by

Set1^HMS00581 is rescued by Set1^{UASp.RR.FRT.EGFP}/Scer\GAL4^{VP16.nanos.UTR}

(Vidaurre et al., 2024)

Not rescued by

Set1^HMS00581 is not rescued by Set1^{E1613K.UASp.RR.FRT.EGFP}/Scer\GAL4^{VP16.nanos.UTR}

(Vidaurre et al., 2024)

Set1^HMS00581 is not rescued by Scer\GAL4^{VP16.nanos.UTR}/Set1^{UASp.FRT.EGFP}

(Vidaurre et al., 2024)

Comments

Images (0)

Mutant

Wild-type

Stocks (2)

Bloomington

33704

y¹ sc^* v¹ sev²¹; P{TRiP.HMS00581}attP2

NIG-Fly

HMS00581

y¹ sc^* v¹ sev²¹; P{TRiP.HMS00581}attP2

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (3)

Reported As

Symbol Synonym

CG40351^HMS00581

Set1^HMS00581

Set1^RNAi1

(Kummeling et al., 2021)

Name Synonyms

Secondary FlyBase IDs

References (10)

Report Sections