FlyBase Allele Report: Dmel\twe[HMS00642]

General Information

Symbol

Dmel\twe^HMS00642

Species

D. melanogaster

Name

FlyBase ID

FBal0257326

Feature type

allele

Associated gene

Dmel\twe

Associated Insertion(s)

Carried in Construct

P{TRiP.HMS00642}

Key Links

Genomic Maps

JBrowse

Transgenic product class

RNAi_reagent

(Ni et al., 2010.12.1)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

RNAi_reagent

(Ni et al., 2010.12.1)

Mutagen

in vitro construct

(Ni et al., 2010.12.1)

Progenitor genotype

Carried in construct

P{TRiP.HMS00642}

Cytology

Description

UAS regulatory sequences drive expression of a short inverted repeat.

(Ni et al., 2010.12.1)

Allele components

Component

Use(s)

Regulatory region(s)

UAS

binary expression system - regulatory region

Encoded product / tool

dsRNA-HMS00642

Also carries

loxP

recombinase target site

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal neuroanatomy | larval stage, with Scer\GAL4^ppk.PG

(Li et al., 2021)

female semi-sterile, with Scer\GAL4^{VP16.nanos.UTR}, Scer\GAL4^VP16.otu, Scer\GAL4^nanos.PG

(Sopko et al., 2014)

Phenotype Manifest In

axon | larval stage, with Scer\GAL4^ppk.PG

(Li et al., 2021)

embryo | maternal effect, with Scer\GAL4^{VP16.nanos.UTR}, Scer\GAL4^VP16.otu, Scer\GAL4^nanos.PG

(Sopko et al., 2014)

larval multidendritic class IV neuron, with Scer\GAL4^ppk.PG

(Li et al., 2021)

Detailed Description

Statement

Reference

Individuals expressing twe^HMS00642 under the control of Scer\GAL4^ppk.PG show decreased class IV da neuron axonal regeneration.

(Li et al., 2021)

Females heterozygous for twe^HMS00642 and MTD-Gal4 (consists of Scer\GAL4^{otu.T:Hsim\VP16}, Scer\GAL4^nos.PG and Scer\GAL4^{nos.UTR.T:Hsim\VP16}) crossed to twe^HMS00642 males results in: 33% hatching; egg/embryonic phenotype: few embryos develop; maternal effect.

(Sopko et al., 2014)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressor of

Statement

Reference

Scer\GAL4^19-12/twe^HMS00642 is a suppressor of abnormal neuroanatomy | larval stage | conditional phenotype of mei-41^29D

(Li et al., 2021)

Phenotype Manifest In