FlyBase Allele Report: Dmel\TER94[HMS00656]

FB2025_01 , released February 20, 2025

FB2025_01 , released February 20, 2025

Allele: Dmel\TER94^HMS00656

General Information

Symbol

Dmel\TER94^HMS00656

Species

D. melanogaster

Name

FlyBase ID

FBal0257340

Feature type

allele

Associated gene

Associated Insertion(s)

Carried in Construct

P{TRiP.HMS00656}

Also Known As

UAS-TER94^RNAi, TER94 RNAi

Key Links

Genomic Maps

Transgenic product class

(Ni et al., 2010.12.1)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

(Ni et al., 2010.12.1)

Mutagen

in vitro construct

(Ni et al., 2010.12.1)

Progenitor genotype

Carried in construct

P{TRiP.HMS00656}

Cytology

Description

UAS regulatory sequences drive expression of a short inverted repeat.

(Ni et al., 2010.12.1)

Allele components

Component

Use(s)

Regulatory region(s)

binary expression system - regulatory region

Encoded product / tool

Also carries

recombinase target site

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 1 )

Disease

Evidence

References

model of frontotemporal dementia and/or amyotrophic lateral sclerosis 6

CEA

(Tendulkar et al., 2022)

Modifiers Based on Experimental Evidence ( 1 )

Disease

Interaction

References

ameliorates Machado-Joseph disease

modeled by Hsap\ATXN3^fl.SCA3.UAS

(Ristic et al., 2018)

ameliorates amyotrophic lateral sclerosis type 8

modeled by Vap33^Δ166, Vap33^ALS8

(Thulasidharan et al., 2024)

modeled by Vap33^Δ166, Vap33^P58S.cRa.UAS

(Tendulkar et al., 2022)

exacerbates amyotrophic lateral sclerosis type 8

modeled by Vap33^Δ166, Vap33^P58S.cRa.UAS

(Tendulkar et al., 2022)

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal developmental rate | maternal effect, with Scer\GAL4^{VP16.mat.αTub67C}

(Das et al., 2024)

decreased size | adult stage, with Scer\GAL4^nub.PU

(Li et al., 2024)

decreased size | adult stage, with Scer\GAL4^sd.PU

(Li et al., 2024)

increased cell death | larval stage, with Scer\GAL4^sd.PU

(Li et al., 2024)

increased cell number | adult stage, with Scer\GAL4^{Delta-05151-G}

(Liu et al., 2022)

increased cell number | adult stage, with Scer\GAL4^NP5130

(Liu et al., 2022)

increased cell number | adult stage, with Scer\GAL4^{Su(H).GBE.cLa}

(Liu et al., 2022)

increased occurrence of cell division | adult stage, with Scer\GAL4^NP5130

(Liu et al., 2022)

majority die during embryonic stage | maternal effect, with Scer\GAL4^{VP16.mat.αTub67C}

(Das et al., 2024)

visible | adult stage, with Scer\GAL4^nub.PU

(Li et al., 2024)

visible | adult stage, with Scer\GAL4^sd.PU

(Li et al., 2024)

Phenotype Manifest In

adult midgut progenitor cell | increased number, with Scer\GAL4^NP5130

(Liu et al., 2022)

centrosome | embryonic stage | maternal effect, with Scer\GAL4^{VP16.mat.αTub67C}

(Das et al., 2024)

enteroblast | adult stage | increased number, with Scer\GAL4^{Delta-05151-G}

(Liu et al., 2022)

enteroblast | adult stage | increased number, with Scer\GAL4^NP5130

(Liu et al., 2022)

enteroblast | adult stage | increased number, with Scer\GAL4^{Su(H).GBE.cLa}

(Liu et al., 2022)

filamentous actin | embryonic stage, with Scer\GAL4^{VP16.mat.αTub67C}

(Das et al., 2024)

intestinal stem cell | adult stage | increased number, with Scer\GAL4^{Delta-05151-G}

(Liu et al., 2022)

intestinal stem cell | adult stage | increased number, with Scer\GAL4^NP5130

(Liu et al., 2022)

nucleus | embryonic stage, with Scer\GAL4^{VP16.mat.αTub67C}

(Das et al., 2024)

pole bud | embryonic stage | maternal effect, with Scer\GAL4^{VP16.mat.αTub67C}

(Das et al., 2024)

wing, with Scer\GAL4^nub.PU

(Li et al., 2024)

wing, with Scer\GAL4^sd.PU

(Li et al., 2024)

wing disc | larval stage, with Scer\GAL4^sd.PU

(Li et al., 2024)

Detailed Description

Statement

Reference

Adulthood expression of TER94^HMS00656 under the control of Scer\GAL4^NP5130 for 7 days leads to an increase in the number and proportion of progenitors (i.e. esg-positive) and stem cells (i.e. Dl-positive) in the midgut, as well as increase in the mitotic index; there are also increased proportion of enteroblasts in the midgut.

Adulthood expression of TER94^HMS00656 under the control of Scer\GAL4^Dl-05151-G for 7 days leads to an increase in the number of stem cells and enteroblasts in the midgut.

Adulthood expression of TER94^HMS00656 under the control of Scer\GAL4^{Su(H).GBE.cLa} for 7 days leads to an increase in the number of enteroblasts in the midgut.

(Liu et al., 2022)

External Data

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressed by

Statement

Reference

Scer\GAL4^nub.PU, TER94^HMS00656 has decreased size | adult stage phenotype, suppressible by Hsap\VCP^UAS.Tag:V5, Scer\GAL4^nub.PU

(Li et al., 2024)

Scer\GAL4^nub.PU, TER94^HMS00656 has visible | adult stage phenotype, suppressible by Hsap\VCP^UAS.Tag:V5, Scer\GAL4^nub.PU

(Li et al., 2024)

Scer\GAL4^nub.PU, TER94^HMS00656 has decreased size | adult stage phenotype, suppressible by Hsap\VCP^{UAS.Tag:NES(Unk).Tag:V5}, Scer\GAL4^nub.PU

(Li et al., 2024)

Scer\GAL4^nub.PU, TER94^HMS00656 has visible | adult stage phenotype, suppressible by Hsap\VCP^{UAS.Tag:NES(Unk).Tag:V5}, Scer\GAL4^nub.PU

(Li et al., 2024)

Scer\GAL4^sd.PU, TER94^HMS00656 has increased cell death | larval stage phenotype, suppressible by Hsap\VCP^UAS.Tag:V5, Scer\GAL4^sd.PU

(Li et al., 2024)

Scer\GAL4^sd.PU, TER94^HMS00656 has increased cell death | larval stage phenotype, suppressible by Hsap\VCP^{UAS.Tag:NES(Unk).Tag:V5}, Scer\GAL4^sd.PU

(Li et al., 2024)

Scer\GAL4^NP5130, TER94^HMS00656 has increased cell number | adult stage phenotype, suppressible by Cat^UAS.cAa, Scer\GAL4^NP5130

(Liu et al., 2022)

Scer\GAL4^NP5130, TER94^HMS00656 has increased cell number | adult stage phenotype, suppressible by Scer\GAL4^NP5130/cnc^UAS.cSa

(Liu et al., 2022)

Scer\GAL4^NP5130, TER94^HMS00656 has increased cell number | adult stage phenotype, suppressible by bsk^HMS00777/Scer\GAL4^NP5130

(Liu et al., 2022)

NOT suppressed by

Statement

Reference

Scer\GAL4^nub.PU, TER94^HMS00656 has decreased size | adult stage phenotype, non-suppressible by Hsap\VCP^{UAS.Tag:NLS(Unk).Tag:V5}, Scer\GAL4^nub.PU

(Li et al., 2024)

Scer\GAL4^nub.PU, TER94^HMS00656 has visible | adult stage phenotype, non-suppressible by Hsap\VCP^{UAS.Tag:NLS(Unk).Tag:V5}, Scer\GAL4^nub.PU

(Li et al., 2024)

Scer\GAL4^sd.PU, TER94^HMS00656 has increased cell death | larval stage phenotype, non-suppressible by Hsap\VCP^{UAS.Tag:NLS(Unk).Tag:V5}, Scer\GAL4^sd.PU

(Li et al., 2024)

Phenotype Manifest In

Suppressed by

Statement

Reference

Scer\GAL4^nub.PU, TER94^HMS00656 has wing phenotype, suppressible by Hsap\VCP^UAS.Tag:V5, Scer\GAL4^nub.PU

(Li et al., 2024)

Scer\GAL4^nub.PU, TER94^HMS00656 has wing phenotype, suppressible by Hsap\VCP^{UAS.Tag:NES(Unk).Tag:V5}, Scer\GAL4^nub.PU

(Li et al., 2024)

Scer\GAL4^sd.PU, TER94^HMS00656 has wing disc | larval stage phenotype, suppressible by Hsap\VCP^UAS.Tag:V5, Scer\GAL4^sd.PU

(Li et al., 2024)

Scer\GAL4^sd.PU, TER94^HMS00656 has wing disc | larval stage phenotype, suppressible by Hsap\VCP^{UAS.Tag:NES(Unk).Tag:V5}, Scer\GAL4^sd.PU

(Li et al., 2024)

Scer\GAL4^NP5130, TER94^HMS00656 has adult midgut progenitor cell | increased number phenotype, suppressible by Scer\GAL4^NP5130/bsk^K53R.UAS

(Liu et al., 2022)

Scer\GAL4^NP5130, TER94^HMS00656 has enteroblast | increased number | adult stage phenotype, suppressible by Cat^UAS.cAa, Scer\GAL4^NP5130

(Liu et al., 2022)

Scer\GAL4^NP5130, TER94^HMS00656 has adult midgut progenitor cell | increased number phenotype, suppressible by Cat^UAS.cAa, Scer\GAL4^NP5130

(Liu et al., 2022)

Scer\GAL4^NP5130, TER94^HMS00656 has adult midgut progenitor cell | increased number phenotype, suppressible by Scer\GAL4^NP5130/cnc^UAS.cSa

(Liu et al., 2022)

Scer\GAL4^NP5130, TER94^HMS00656 has adult midgut progenitor cell | increased number phenotype, suppressible by bsk^HMS00777/Scer\GAL4^NP5130

(Liu et al., 2022)

NOT suppressed by

Statement

Reference

Scer\GAL4^nub.PU, TER94^HMS00656 has wing phenotype, non-suppressible by Hsap\VCP^{UAS.Tag:NLS(Unk).Tag:V5}, Scer\GAL4^nub.PU

(Li et al., 2024)

Scer\GAL4^sd.PU, TER94^HMS00656 has wing disc | larval stage phenotype, non-suppressible by Hsap\VCP^{UAS.Tag:NLS(Unk).Tag:V5}, Scer\GAL4^sd.PU

(Li et al., 2024)

Suppressor of

Statement

Reference

TER94^HMS00656, Scer\GAL4^GMR.long is a suppressor | partially of eye | progressive phenotype of Hsap\ATXN3^fl.SCA3.UAS, Scer\GAL4^GMR.long

(Ristic et al., 2018)

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Rescued by

TER94^HMS00656 is rescued by Scer\GAL4^nub.PU/TER94^{UAS.cLa.Tag:V5}

(Li et al., 2024)

TER94^HMS00656 is rescued by Scer\GAL4^sd.PU/TER94^{UAS.cLa.Tag:V5}

(Li et al., 2024)

Comments

Images (0)

Mutant

Wild-type

Stocks (2)

32869

y¹ sc^* v¹ sev²¹; P{TRiP.HMS00656}attP2

HMS00656

y¹ sc^* v¹ sev²¹; P{TRiP.HMS00656}attP2

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (1)

Reported As

Symbol Synonym

TER94^HMS00656

Name Synonyms

Secondary FlyBase IDs

References (15)

Report Sections