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General Information
Symbol
Dmel\mopHMS00706
Species
D. melanogaster
Name
FlyBase ID
FBal0257389
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Also Known As
HMS00706
Allele class
Nature of the Allele
Allele class
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Carried in construct
Cytology
Nature of the lesion
Statement
Reference
UAS regulatory sequences drive expression of a short inverted repeat.
Allele components
Product class / Tool use(s)
Encoded product / tool
Associated Sequence Features
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference
Knockdown of mopHMS00706 driven in the class IV dendritic arborizing sensory neuron ddaC by Scer\GAL4ppk.1.9 leads to disruptions in pruning at 18hr (but not 0hr) after puparium formation, with dendrites still attached to the cell body (resulting from a lack of branch severing and clearance defects). Knockdown of mopHMS00706 driven in the class IV dendritic arborizing sensory neuron ddaC by Scer\GAL4ppk.1.9 leads to accumulation of ubiquitinated proteins (defects in multivesicular body formation) in third instar larvae. Knockdown of mopHMS00706 driven in class I da sensory neurons by Scer\GAL4smid-C161 or in mushroom body gamma neurons by Scer\GAL4Tab2-201Y leads to significant disruption in dendrite or axon (respectively) severing at 24hr after puparium formation, compared to controls.
Females heterozygous for mopHMS00706 and MTD-Gal4 (consists of Scer\GAL4otu.T:Hsim\VP16, Scer\GAL4nos.PG and Scer\GAL4nos.UTR.T:Hsim\VP16) crossed to mopHMS00706 males results in: 11% hatching; egg/embryonic phenotype: "empty, all white"; maternal effect.
External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Phenotype Manifest In
Additional Comments
Genetic Interactions
Statement
Reference
Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Comments
Co-expression of mopWD.Scer\UAS (but not mopmut.Scer\UAS) rescues dendrite pruning defects seen when mopHMS00706 is driven in the class IV dendritic arborizing sensory neuron ddaC by Scer\GAL4ppk.1.9 at 18hr after puparium formation.
Images (0)
Mutant
Wild-type
Stocks (1)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (1)
Reported As
Symbol Synonym
mopHMS00706
Name Synonyms
Secondary FlyBase IDs
    References (6)