FB2020_06, released Dec 22, 2020

Allele: Dmel\Brr2HMS00994

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General Information
Symbol
Dmel\Brr2HMS00994
Species
D. melanogaster
Name
FlyBase ID
FBal0257662
Feature type
allele
Associated gene
Dmel\Brr2
Associated Insertion(s)
Carried in Construct
P{TRiP.HMS00994}
Genomic Maps
Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
in vitro construct - RNAi
(Ni et al., 2010.12.1)
in vitro construct - regulatory fusion
(Ni et al., 2010.12.1)
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
       
      Progenitor genotype
      Carried in construct
      P{TRiP.HMS00994}
      Cytology
      Nature of the lesion
      Statement
      Reference

      UAS regulatory sequences drive expression of a short inverted repeat.

      (Ni et al., 2010.12.1)
      Allele components
      Product class / Tool use(s)
      Regulatory region(s)
      UAS
      Encoded product / tool
      Brr2
      Also carries
      loxP
      Associated Sequence Features
      dsRNA-HMS00994
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Expressing l(3)72AbHMS00994 under the control of Scer\GAL4Cg.PA leads to fragmented and clustered mitochondria in the third instar larval fat body (as assessed by MitoGFP).

      (Zhou et al., 2019)

      The expression of l(3)72AbHMS00994 under the control of Scer\GAL4SPARC-MI00329-GAL4 (and Dicer-2, for a more efficient RNAi) in the larval fat body induces defective secretion, including intracellular matrix material, as shown by the retention of both secr.GFP and Vkg.GFP.

      (Ke et al., 2018)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer
      Comments
      Comments

      Supplemental Dataset_S01.

      (Yan and Perrimon, 2015)
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (3)
      Reported As
      Symbol Synonym
      Brr2HMS00994
      CG5931HMS00994
      l(3)72AbHMS00994
      Name Synonyms
      Secondary FlyBase IDs
        References (4)