FB2020_01, released Feb 12, 2020

Allele: Dmel\RhoGEF2HMS01118

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General Information
Symbol
Dmel\RhoGEF2HMS01118
Species
D. melanogaster
Name
FlyBase ID
FBal0257781
Feature type
allele
Associated gene
Dmel\RhoGEF2
Associated Insertion(s)
Carried in Construct
P{TRiP.HMS01118}
Genomic Maps
Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
in vitro construct - RNAi
(Ni et al., 2010.12.1)
in vitro construct - regulatory fusion
(Ni et al., 2010.12.1)
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
       
      Progenitor genotype
      Carried in construct
      P{TRiP.HMS01118}
      Cytology
      Nature of the lesion
      Statement
      Reference

      UAS regulatory sequences drive expression of a short inverted repeat.

      (Ni et al., 2010.12.1)
      Allele components
      Product class / Tool use(s)
      Regulatory region(s)
      UAS
      Encoded product / tool
      RhoGEF2
      Also carries
      loxP
      Associated Sequence Features
      dsRNA-HMS01118
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 1 )
      Disease
      Evidence
      References
      model of  cancer
      CEA with Stat92EΔNΔC.UASp.Tag:HA, scribKK101128
      (Tamori et al., 2016)
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Wounded embryos expressing RhoGEF2HMS01118 under the control of Scer\GAL4mat.αTub67C.T:Hsim\VP16 show wound overexpansion, delayed actin accumulation around the wound edge and delayed repair, as compared to wounded control embryos.

      (Nakamura et al., 2017)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      The clonal co-expression of either l(2)glGD4047 and RhoGEF2HMS01118 or scribKK101128 and RhoGEF2HMS01118 under the control of Scer\GAL4Act5C.PI (together with Dicer-2, for efficient RNAi) in third instar larval wing discs leads to a significant proportion of apical delamination, which does not occur upon l(2)glGD4047 or scribKK101128 single expression clones.

      The clonal co-expression of scribKK101128, RhoGEF2HMS01118 and Stat92EΔNΔC.UASp.Tag:HA under the control of Scer\GAL4Act5C.PI (together with Dicer-2, for efficient RNAi) in third instar larval wing discs leads to overgrowths in the wing pouch domain, which does not occur upon scribKK101128 single expression or scribKK101128, RhoGEF2HMS01118 double expression.

      (Tamori et al., 2016)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      RhoGEF2HMS01118
      RhoGEF2RNAi(1)
      (Nakamura et al., 2017)
      Name Synonyms
      Secondary FlyBase IDs
        References (6)