FlyBase Allele Report: Dmel\Orp8[HMS01223]

General Information

Symbol

Dmel\Orp8^HMS01223

Species

D. melanogaster

Name

FlyBase ID

FBal0257879

Feature type

allele

Associated gene

Dmel\Orp8

Associated Insertion(s)

Carried in Construct

P{TRiP.HMS01223}

Key Links

Genomic Maps

JBrowse

Transgenic product class

RNAi_reagent

(Ni et al., 2010.12.1)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

RNAi_reagent

(Ni et al., 2010.12.1)

Mutagen

in vitro construct

(Ni et al., 2010.12.1)

Progenitor genotype

Carried in construct

P{TRiP.HMS01223}

Cytology

Description

UAS regulatory sequences drive expression of a short inverted repeat.

(Ni et al., 2010.12.1)

Allele components

Component

Use(s)

Regulatory region(s)

UAS

binary expression system - regulatory region

Encoded product / tool

dsRNA-HMS01223

Also carries

loxP

recombinase target site

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 1 )

Disease

Interaction

References

exacerbates hereditary spastic paraplegia 61

modeled by Arl6IP1^KK109154

(Byrne et al., 2022)

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

Phenotype Manifest In

abdominal segment motor neuron, with Scer\GAL4^nSyb.PS

(Byrne et al., 2022)

axon, with Scer\GAL4^nSyb.PS

(Byrne et al., 2022)

larval abdominal segment 7, with Scer\GAL4^nSyb.PS

(Byrne et al., 2022)

lipid droplet | increased number | third instar larval stage, with Scer\GAL4^nSyb.PS

(Byrne et al., 2022)

Detailed Description

Statement

Reference

The expression of Arl6IP1^KK109154 under the control of Scer\GAL4^nSyb.PS induces an increased number of lipid droplets in axon bundles of the long motor neurons of third instar larvae (i.e. targeting A7).

(Byrne et al., 2022)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Phenotype Manifest In

Enhanced by

Statement

Reference

Orp8^HMS01223, Scer\GAL4^nSyb.PS has larval abdominal segment 7 phenotype, enhanceable by Arl6IP1^KK109154, Scer\GAL4^nSyb.PS

(Byrne et al., 2022)

Orp8^HMS01223, Scer\GAL4^nSyb.PS has lipid droplet | third instar larval stage | increased number phenotype, enhanceable by Arl6IP1^KK109154, Scer\GAL4^nSyb.PS

(Byrne et al., 2022)

Orp8^HMS01223, Scer\GAL4^nSyb.PS has abdominal segment motor neuron phenotype, enhanceable by Arl6IP1^KK109154, Scer\GAL4^nSyb.PS

(Byrne et al., 2022)

Orp8^HMS01223, Scer\GAL4^nSyb.PS has axon phenotype, enhanceable by Arl6IP1^KK109154, Scer\GAL4^nSyb.PS

(Byrne et al., 2022)

Enhancer of

Statement

Reference

Orp8^HMS01223, Scer\GAL4^nSyb.PS is an enhancer of larval abdominal segment 7 phenotype of Arl6IP1^KK109154, Scer\GAL4^nSyb.PS

(Byrne et al., 2022)

Orp8^HMS01223, Scer\GAL4^nSyb.PS is an enhancer of abdominal segment motor neuron phenotype of Arl6IP1^KK109154, Scer\GAL4^nSyb.PS

(Byrne et al., 2022)

Orp8^HMS01223, Scer\GAL4^nSyb.PS is an enhancer of axon phenotype of Arl6IP1^KK109154, Scer\GAL4^nSyb.PS

(Byrne et al., 2022)

Orp8^HMS01223, Scer\GAL4^nSyb.PS is an enhancer of lipid droplet | third instar larval stage | increased number phenotype of Arl6IP1^KK109154, Scer\GAL4^nSyb.PS

(Byrne et al., 2022)

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (2)

Bloomington

34743

y¹ sc^* v¹ sev²¹; P{TRiP.HMS01223}attP2

NIG-Fly

HMS01223

y¹ sc^* v¹ sev²¹; P{TRiP.HMS01223}attP2

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

CG42668^HMS01223

Orp8^HMS01223

Name Synonyms

Secondary FlyBase IDs

References (2)

Report Sections

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