FlyBase Allele Report: Dmel\Rok[HMS01311]

General Information

Symbol

Dmel\Rok^HMS01311

Species

D. melanogaster

Name

FlyBase ID

FBal0257904

Feature type

allele

Associated gene

Dmel\Rok

Associated Insertion(s)

Carried in Construct

P{TRiP.HMS01311}

Also Known As

HMS01311, UAS-Rok RNAi, Rok RNAi

Key Links

Genomic Maps

JBrowse

Transgenic product class

RNAi_reagent

(Ni et al., 2010.12.1)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

RNAi_reagent

(Ni et al., 2010.12.1)

Mutagen

in vitro construct

(Ni et al., 2010.12.1)

Progenitor genotype

Carried in construct

P{TRiP.HMS01311}

Cytology

Description

UAS regulatory sequences drive expression of a short inverted repeat.

(Ni et al., 2010.12.1)

Allele components

Component

Use(s)

Regulatory region(s)

UAS

binary expression system - regulatory region

Encoded product / tool

dsRNA-HMS01311

Also carries

loxP

recombinase target site

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 1 )

Disease

Interaction

References

ameliorates Charcot-Marie-Tooth disease type 4B1

modeled by mtm^G447D

(Hu et al., 2022)

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal size | spermatogenesis, with Scer\GAL4^upd1-E132

(Vida et al., 2025)

female semi-sterile, with Scer\GAL4^{VP16.nanos.UTR}, Scer\GAL4^VP16.otu, Scer\GAL4^nanos.PG

(Sopko et al., 2014)

Phenotype Manifest In

somatic cell of testis, with Scer\GAL4^upd1-E132

(Vida et al., 2025)

Detailed Description

Statement

Reference

Posterior dorsocentral bristle neurons expressing Rok^HMS01311 under the control of Scer\GAL4^pnr-MD237 do not show obvious projection defects compared to controls.

(Urwyler et al., 2019)

Females heterozygous for Rok^HMS01311 and MTD-Gal4 (consists of Scer\GAL4^{otu.T:Hsim\VP16}, Scer\GAL4^nos.PG and Scer\GAL4^{nos.UTR.T:Hsim\VP16}) crossed to Rok^HMS01311 males results in: 80% hatching; non-maternal effect.

(Sopko et al., 2014)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressor of

Statement

Reference

Rok^HMS01311/Scer\GAL4^αTub84B.PL is a suppressor of increased cell number | P-stage | somatic clone - tissue specific phenotype of mtm^null

(Hu et al., 2022)

Rok^HMS01311/Scer\GAL4^αTub84B.PL is a suppressor | partially of increased cell number | P-stage | somatic clone - tissue specific phenotype of ft⁸, mtm^null

(Hu et al., 2022)

Rok^HMS01311/Scer\GAL4^αTub84B.PL is a suppressor | partially of increased cell number | P-stage | somatic clone - tissue specific phenotype of ex^e1, mtm^null

(Hu et al., 2022)

Rok^HMS01311/Scer\GAL4^αTub84B.PL is a suppressor of increased size | somatic clone | adult stage phenotype of ex^e1, mtm^null

(Hu et al., 2022)

Rok^HMS01311, Scer\GAL4^repo.PU is a suppressor of abnormal neuroanatomy | third instar larval stage phenotype of Pi3K92E^{UAS.Tag:MYC,Tag:PM(hKRAS)}, Scer\GAL4^repo.PU, btl::Egfr^λ.UAS

(Chen et al., 2019)

Rok^HMS01311, Scer\GAL4^repo.PU is a suppressor of neoplasia | third instar larval stage phenotype of Pi3K92E^{UAS.Tag:MYC,Tag:PM(hKRAS)}, Scer\GAL4^repo.PU, btl::Egfr^λ.UAS

(Chen et al., 2019)

Rok^HMS01311, Scer\GAL4^hs.2sev is a suppressor of increased cell death phenotype of Mmus\Gria1^Lc.UAS, Scer\GAL4^hs.2sev

(Yang et al., 2013)

Phenotype Manifest In

Suppressor of

Statement

Reference

Rok^HMS01311/Scer\GAL4^αTub84B.PL is a suppressor of interommatidial cell | increased number | P-stage | somatic clone - tissue specific phenotype of mtm^null

(Hu et al., 2022)

Rok^HMS01311/Scer\GAL4^αTub84B.PL is a suppressor | partially of interommatidial cell | increased number | P-stage | somatic clone - tissue specific phenotype of ft⁸, mtm^null

(Hu et al., 2022)

Rok^HMS01311/Scer\GAL4^αTub84B.PL is a suppressor | partially of interommatidial cell | increased number | P-stage | somatic clone - tissue specific phenotype of ex^e1, mtm^null

(Hu et al., 2022)

Rok^HMS01311/Scer\GAL4^αTub84B.PL is a suppressor of mesonotum | somatic clone | adult stage phenotype of ex^e1, mtm^null

(Hu et al., 2022)

Rok^HMS01311, Scer\GAL4^repo.PU is a suppressor of larval brain | third instar larval stage phenotype of Pi3K92E^{UAS.Tag:MYC,Tag:PM(hKRAS)}, Scer\GAL4^repo.PU, btl::Egfr^λ.UAS

(Chen et al., 2019)

Rok^HMS01311, Scer\GAL4^repo.PU is a suppressor of larval brain neuropil glial cell | third instar larval stage phenotype of Pi3K92E^{UAS.Tag:MYC,Tag:PM(hKRAS)}, Scer\GAL4^repo.PU, btl::Egfr^λ.UAS

(Chen et al., 2019)

Rok^HMS01311, Scer\GAL4^hs.2sev is a suppressor of eye phenotype of Mmus\Gria1^Lc.UAS, Scer\GAL4^hs.2sev

(Yang et al., 2013)

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

A rok^HMS01311 background rescues the reduced adult eye size phenotype found in Scer\GAL4^hs.2sev->Mmus\Gria1^Lc.Scer\UAS flies.

(Yang et al., 2013)

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (2)

Bloomington

34324

y¹ sc^* v¹ sev²¹; P{TRiP.HMS01311}attP2

NIG-Fly

HMS01311

y¹ sc^* v¹ sev²¹; P{TRiP.HMS01311}attP2

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

Rok^HMS01311

rok^HMS01311

Name Synonyms

Secondary FlyBase IDs

References (16)

Report Sections

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