FlyBase Allele Report: Dmel\dre4[HMS01332]

General Information

Symbol

Dmel\dre4^HMS01332

Species

D. melanogaster

Name

FlyBase ID

FBal0257925

Feature type

allele

Associated gene

Dmel\dre4

Associated Insertion(s)

Carried in Construct

P{TRiP.HMS01332}

Key Links

Genomic Maps

JBrowse

Transgenic product class

RNAi_reagent

(Ni et al., 2010.12.1)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

RNAi_reagent

(Ni et al., 2010.12.1)

Mutagen

in vitro construct

(Ni et al., 2010.12.1)

Progenitor genotype

Carried in construct

P{TRiP.HMS01332}

Cytology

Description

UAS regulatory sequences drive expression of a short inverted repeat.

(Ni et al., 2010.12.1)

Allele components

Component

Use(s)

Regulatory region(s)

UAS

binary expression system - regulatory region

Encoded product / tool

dsRNA-HMS01332

Also carries

loxP

recombinase target site

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 1 )

Disease

Evidence

References

model of neurodevelopmental disorder with dysmorphic facies and thin corpus callosum

CEC

(Ma et al., 2023)

Modifiers Based on Experimental Evidence ( 1 )

Disease

Interaction

References

model of neurodevelopmental disorder with dysmorphic facies and thin corpus callosum

is ameliorated by Hsap\SUPT16H^Ref.UAS

(Ma et al., 2023)

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal developmental rate, with Scer\GAL4^phtm.PO

(Ma et al., 2023)

decreased cell size | larval stage, with Scer\GAL4^wor.PU

(Lou et al., 2024)

decreased rate of adult locomotory behavior, with Scer\GAL4^wor.PU

(Lou et al., 2024)

decreased size, with Scer\GAL4^phtm.PO

(Ma et al., 2023)

decreased size | larval stage, with Scer\GAL4^unspecified

(Lou et al., 2024)

increased cell death | larval stage, with Scer\GAL4^Bx-MS1096-KE

(Ma et al., 2023)

lethal - all die before end of second instar larval stage, with Scer\GAL4^Act5C.PI

(Ma et al., 2023)

lethal - all die before end of second instar larval stage, with Scer\GAL4^Act5C.PP

(Ma et al., 2023)

lethal - all die before end of second instar larval stage, with Scer\GAL4^da.G32

(Ma et al., 2023)

lethal - all die before end of second instar larval stage, with Scer\GAL4^αTub84B.PL

(Ma et al., 2023)

partially lethal - majority live, with Scer\GAL4^elav.PLu

(Ma et al., 2023)

short lived, with Scer\GAL4^elav.PLu

(Ma et al., 2023)

short lived, with Scer\GAL4^wor.PU

(Lou et al., 2024)

some die during first instar larval stage, with Scer\GAL4^Act5C.PI

(Ma et al., 2023)

some die during first instar larval stage, with Scer\GAL4^Act5C.PP

(Ma et al., 2023)

some die during first instar larval stage, with Scer\GAL4^da.G32

(Ma et al., 2023)

some die during first instar larval stage, with Scer\GAL4^αTub84B.PL

(Ma et al., 2023)

some die during second instar larval stage, with Scer\GAL4^Act5C.PI

(Ma et al., 2023)

some die during second instar larval stage, with Scer\GAL4^Act5C.PP

(Ma et al., 2023)

some die during second instar larval stage, with Scer\GAL4^da.G32

(Ma et al., 2023)

some die during second instar larval stage, with Scer\GAL4^αTub84B.PL

(Ma et al., 2023)

Phenotype Manifest In

larval brain, with Scer\GAL4^unspecified

(Lou et al., 2024)

larval neuroblast, with Scer\GAL4^wor.PU

(Lou et al., 2024)

prothoracic gland, with Scer\GAL4^phtm.PO

(Ma et al., 2023)

wing disc | larval stage, with Scer\GAL4^Bx-MS1096-KE

(Ma et al., 2023)

Detailed Description

Statement

Reference

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressed by

Statement

Reference

Scer\GAL4^elav.PLu, dre4^HMS01332 has short lived phenotype, suppressible | partially by Hsap\SUPT16H^Ref.UAS, Scer\GAL4^elav.PLu

(Ma et al., 2023)

Scer\GAL4^elav.PLu, dre4^HMS01332 has short lived phenotype, suppressible | partially by Hsap\SUPT16H^T171I.UAS, Scer\GAL4^elav.PLu

(Ma et al., 2023)

Scer\GAL4^elav.PLu, dre4^HMS01332 has short lived phenotype, suppressible | partially by Hsap\SUPT16H^G808R.UAS, Scer\GAL4^elav.PLu

(Ma et al., 2023)

Other

Statement

Reference

Hsap\SUPT16H^Ref.UAS, Scer\GAL4^Act5C.PP, dre4^HMS01332 has lethal - all die before end of P-stage phenotype

(Ma et al., 2023)

Phenotype Manifest In

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (2)

Bloomington

34344

y¹ sc^* v¹ sev²¹; P{TRiP.HMS01332}attP2

NIG-Fly

HMS01332

y¹ sc^* v¹ sev²¹; P{TRiP.HMS01332}attP2

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (1)

Reported As

Symbol Synonym

dre4^HMS01332

Name Synonyms

Secondary FlyBase IDs

References (3)

Report Sections

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