FB2025_01 , released February 20, 2025
Allele: Dmel\Pgm1HMS01333
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General Information
Symbol
Dmel\Pgm1HMS01333
Species
D. melanogaster
Name
FlyBase ID
FBal0257926
Feature type
allele
Associated gene
Dmel\Pgm1
Associated Insertion(s)
Carried in Construct
P{TRiP.HMS01333}
Key Links
Genomic Maps

Transgenic product class
RNAi_reagent
(Ni et al., 2010.12.1)
Mutagen
Nature of the Allele
Transgenic product class
RNAi_reagent
(Ni et al., 2010.12.1)
Mutagen
in vitro construct
(Ni et al., 2010.12.1)
Progenitor genotype
Carried in construct
P{TRiP.HMS01333}
Cytology
Description

UAS regulatory sequences drive expression of a short inverted repeat.

(Ni et al., 2010.12.1)
Allele components
Component
Use(s)
Regulatory region(s)
UAS
Encoded product / tool
dsRNA-HMS01333
Also carries
loxP
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 1 )
      Disease
      Interaction
      References
      exacerbates  Alzheimer's disease
      modeled by Hsap\APP2xAPP.SP.UAS
      (Minjarez et al., 2016)
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      The expression of Pgm1HMS01333 under the control of Scer\GAL4SPARC-MI00329-GAL4 (and Dicer-2, for a more efficient RNAi) in the larval fat body induces defective secretion, including intracellular matrix material, as shown by the retention of both secr.GFP and Vkg.GFP.

      (Ke et al., 2018)

      Expression of PgmHMS01333 RNAi under the control of Scer\GAL4GMR.PU does not disrupt eye morphology in adults.

      (Minjarez et al., 2016)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Enhancer of
      NOT Enhancer of
      Statement
      Reference

      Pgm1HMS01333, Scer\GAL4GMR.PU is a non-enhancer of visible | adult stage phenotype of Hsap\MAPTUAS.B, Scer\GAL4GMR.PU

      (Minjarez et al., 2016)
      Phenotype Manifest In
      Enhancer of
      NOT Enhancer of
      Statement
      Reference

      Pgm1HMS01333, Scer\GAL4GMR.PU is a non-enhancer of eye | adult stage phenotype of Hsap\MAPTUAS.B, Scer\GAL4GMR.PU

      (Minjarez et al., 2016)
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference

      The defective eye morphology (disrupted ommatidial lattice) observed in adult flies expressing Hsap\MAPTScer\UAS.B under the control of Scer\GAL4GMR.PU is not significantly modified by co-expression of PgmHMS01333 RNAi.

      The glassy eye phenotype and disrupted ommatidial lattice observed in adult flies expressing Hsap\APP2xAPP.SP.Scer\UAS under the control of Scer\GAL4GMR.PU is significantly worsened by co-expression of PgmHMS01333 RNAi with necrotic spots appearing in the posterior eye.

      (Minjarez et al., 2016)
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      Pgm1HMS01333
      PgmHMS01333
      Name Synonyms
      Secondary FlyBase IDs
        References (4)