Deletion mutation.
Heterozygotes have a normal lifespan.
Irbp[+]/IrbpEX8 is an enhancer | female limited of short lived phenotype of Hsap\HTT103Q.Ex1.UAS, Scer\GAL4RapGAP1-OK6
IrbpEX8/IrbpEX8 is a suppressor of nuclear chromosome | third instar larval stage phenotype of tws430
IrbpEX8/IrbpEX8 is a suppressor of embryonic/larval brain | third instar larval stage phenotype of tws430
IrbpfTRG00107.sfGFP-TVPTBF, IrbpEX8/IrbpEX8 is a suppressor | partially of nuclear chromosome | third instar larval stage phenotype of tws430
IrbpfTRG00107.sfGFP-TVPTBF, IrbpEX8/IrbpEX8 is a suppressor | partially of embryonic/larval brain | third instar larval stage phenotype of tws430
Heterozygosity for IrbpEX8 enhances the shortened lifespan phenotype caused by expression of Hsap\HTT103Q.Ex1.Scer\UAS under the control of Scer\GAL4GMR.long. This enhancing effect is seen in females but not males.
Flies expressing Hsap\HTT103Q.Ex1.Scer\UAS under the control of Scer\GAL4Rapgap1-OK6 in a Irbp7B2/IrbpEX8 background show an enhanced age-dependent decline in climbing ability compared to control flies.