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General Information
Symbol
Dmel\Gug66QC.UAS
Species
D. melanogaster
Name
FlyBase ID
FBal0258446
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Allele class
Nature of the Allele
Allele class
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Carried in construct
Cytology
Nature of the lesion
Statement
Reference

UASt regulatory sequences drive expression of a modified form of Gug carrying a 66Q stretch at the C-terminal end.

Allele components
Product class / Tool use(s)
Encoded product / tool
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 1 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 1 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

Expression of Gug66QC.Scer\UAS in the eye under the control of Scer\GAL4GMR.PU results in progressive depigmentation. At 14 days old, degenerating photoreceptor cells display large autophagosomes.

Expression of Gug66QC.Scer\UAS in the adult eye under the control of Scer\GAL4ninaE.PT results in degeneration, characterised by loss of photoreceptor cells.

Expression of Gug66QC.Scer\UAS in the glia under the control of Scer\GAL4Eaat1.PR results in reduced animal viability.

Expression of Gug66QC.Scer\UAS in the neurons under the control of Scer\GAL4elav.PU does not result in reduced animal viability.

Expression of Gug66QC.Scer\UAS in the adult eye under the control of Scer\GAL4GMR.PU, aged at 29[o]C for 28 days, results in a significant degeneration of retinal tissue.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Phenotype Manifest In
Enhanced by
Statement
Reference

Gug66QC.UAS, Scer\GAL4GMR.PU has retina | temperature conditional phenotype, enhanceable by Atg5dsRNA.UAS, Scer\GAL4GMR.PU

Gug66QC.UAS, Scer\GAL4GMR.PU has retina | temperature conditional phenotype, enhanceable by TorTED.UAS, Scer\GAL4GMR.PU

Gug66QC.UAS, Scer\GAL4GMR.PU has retina | temperature conditional phenotype, enhanceable by Atg1GS10797, Scer\GAL4GMR.PU

Additional Comments
Genetic Interactions
Statement
Reference

Expression of Gug66QC.Scer\UAS in the adult eye under the control of Scer\GAL4GMR.PU, aged at 29[o]C for 28 days, results in a significant degeneration of retinal tissue, which is enhanced by co-expression of Atg5dsRNA.Scer\UAS.

Expression of Gug66QC.Scer\UAS in the adult eye under the control of Scer\GAL4GMR.PU, aged at 29[o]C for 28 days, results in a significant degeneration of retinal tissue, which is enhanced by co-expression of TorTED.Scer\UAS.

Expression of Gug66QC.Scer\UAS in the adult eye under the control of Scer\GAL4GMR.PU, aged at 29[o]C for 28 days, results in a significant degeneration of retinal tissue, which is enhanced by co-expression of Atg1GS10797.

Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Comments
Images (0)
Mutant
Wild-type
Stocks (0)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (2)
Reported As
Symbol Synonym
Gug66QC.Scer\UAS
Gug66QC.UAS
Name Synonyms
Secondary FlyBase IDs
    References (2)