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General Information
Symbol
Dmel\dar13010
Species
D. melanogaster
Name
FlyBase ID
FBal0258676
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Allele class
Mutagen
Nature of the Allele
Allele class
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Cytology
Nature of the lesion
Statement
Reference
dar13010 contains a premature stop codon so that only a fragment of the N-terminal half of the protein can be produced, without the nuclear localization signal and zinc finger domains.
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference
dar13010/dar13010 larval dendritic arborizing neurons display loss of the multipolar layout of dendrites, with many becoming bipolar. dar13010/dar13010 larval es neurons not do not show a significant change in morphology as compared to wild type.
In dar13010 mutants, major dendrites of class IV da neurons are either missing or shortened, consequently resulting in a reduced dendritic arbor. In contrast, the axonal growth of these neurons is normal. Dendrites of class I da neurons are also severely shortened. dar13232/dar13010 mutants, generated by crossing dar13232 germline clones with dar13010 mutants show the same phenotype as dar13010 zygotic mutants, that is, the dendrites are reduced but the axons are normal. Dendritic defects are visible as early as 16-17 hours after egg laying and become more pronounced in 18-19 hours after egg laying, suggesting these mutants exhibit reduced outgrowth of dendrites. Single neurons homozygous for dar13010, generated through MARCM, exhibit severely reduced dendritic arbors, supporting the notion that dar1 functions cell-autonomously. Dendrites are dramatically reduced in all four classes of da neurons (class I-ddaD and ddaE, class II-ddaB, class III-ddaA, and class IV-ddaC). In contrast, there is no significant defect in axonal growth in these mutants.
External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Suppressed by
NOT suppressed by
Statement
Reference
Suppressor of
Statement
Reference
NOT Suppressor of
Statement
Reference
Phenotype Manifest In
Suppressed by
NOT suppressed by
Statement
Reference
Suppressor of
Statement
Reference
NOT Suppressor of
Statement
Reference
Additional Comments
Genetic Interactions
Statement
Reference
Expression of nudEScer\UAS.A under the control of Scer\GAL4unspecified partially rescues the increased number of bipolar dendritic arborizing neurons seen in dar13010/dar13010 mutant clones.
A dar13010 mutant background suppresses the increase in dendrite length found upon expression of knScer\UAS.cMa in class I da neurons under the control of Scer\GAL421-7 and results in a severe reduction in dendrite length. A dar13010 mutant background does not block the dendrite branching activity found upon expression of Rac1Scer\UAS.cLa under the control of Scer\GAL4477.
Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Rescued by
Comments
The presence of dar1+tYa rescues the dendrite defects in both class IV and class I neurons mutant for dar13010.
Images (0)
Mutant
Wild-type
Stocks (1)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (1)
Reported As
Name Synonyms
Secondary FlyBase IDs
    References (3)