Allele Dmel\dar1³²³²

General Information
Symbol	Dmel\dar1³²³²	Species	D. melanogaster
Name		FlyBase ID	FBal0258677
Feature type	allele	Associated gene	Dmel\dar1

Allele class
Mutagen	FLPase
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Nature of the Allele
Allele class
Mutagen	FLPase (Ye et al., 2011)
Mutations Mapped to the Genome

Type Location Additional Notes References
Associated Sequence Data
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name

UniProtKB/Swiss-Prot
UniProtKB/TrEMBL

Progenitor genotype
Nature of the lesion	Statement Reference dar1[3232] contains a premature stop codon so that only a fragment of the N-terminal half of the protein can be produced, without the nuclear localization signal and zinc finger domains. (Ye et al., 2011)
Cytology
Phenotypic Data
Phenotypic Class
	neuroanatomy defective (Ye et al., 2011) neuroanatomy defective (with dar1³⁰¹⁰) (Ye et al., 2011)
Phenotype Manifest In
	dendritic arborizing neuron (Ye et al., 2011) dendritic arborizing neuron (with dar1³⁰¹⁰) (Ye et al., 2011)
Detailed Description
	Statement Reference In dar1[3232] mutants, major dendrites of class IV da neurons are either missing or shortened, consequently resulting in a reduced dendritic arbor. In contrast, the axonal growth of these neurons is normal. Dendrites of class I da neurons are also severely shortened. dar1[3232]/dar1[3010] mutants, generated by crossing dar1[3232] germline clones with dar1[3010] mutants show the same phenotype as dar1[3232] zygotic mutants, that is, the dendrites are reduced but the axons are normal. Dendritic defects are visible as early as 16-17 hours after egg laying and become more pronounced in 18-19 hours after egg laying, suggesting these mutants exhibit reduced outgrowth of dendrites. Single neurons homozygous for dar1[3232], generated through MARCM, exhibit severely reduced dendritic arbors, supporting the notion that dar1 functions cell-autonomously. Dendrites are dramatically reduced in all four classes of da neurons (class I-ddaD and ddaE, class II-ddaB, class III-ddaA, and class IV-ddaC). In contrast, there is no significant defect in axonal growth in these mutants. (Ye et al., 2011)
External Data
Linkouts
Interactions
Phenotypic Class
Phenotype Manifest In
Additional Comments
Genetic Interactions
Statement Reference
Xenogenetic Interactions
Statement Reference
Complementation & Rescue Data
Rescued by	dar1³²³² is rescued by dar1^+tYa (Ye et al., 2011)
Comments	The presence of dar1[+tYa] rescues the dendrite defects in both class IV and class I neurons mutant for dar1[3232]. (Ye et al., 2011)
Stocks ( 0 )

Notes on Origin
Discoverer

External Crossreferences & Linkouts
Other Crossreferences

Linkouts

Synonyms & Secondary IDs ( 1 )
Reported As
Symbol Synonym	dar1³²³² (Ye et al., 2011)
Name Synonym
Secondary FlyBase IDs

References ( 1 )
Research paper	Ye et al., 2011, J. Neurosci. 31(9): 3309--3319 Differential regulation of dendritic and axonal development by the novel kruppel-like factor dar1. [FBrf0213162]

Allele Dmel\dar13232

Allele Dmel\dar1³²³²