FB2025_01 , released February 20, 2025
Allele: Scer\GAL419-12
Open Close
General Information
Symbol
Scer\GAL419-12
Species
S. cerevisiae
Name
FlyBase ID
FBal0258681
Feature type
allele
Associated gene
Scer\GAL4
Associated Insertion(s)
P{GAL4}19-12
Carried in Construct
Also Known As
19-12-Gal4, GAL419-12, GAL4-19-12
Allele class
Mutagen
    Nature of the Allele
    Allele class
    Mutagen
    Progenitor genotype
    Associated Insertion(s)
    P{GAL4}19-12
    Cytology
    Description
    Allele components
    Component
    Use(s)
    Inserted element
    P{GAL4}
    Encoded product / tool
    GAL4
    Mutations Mapped to the Genome
    Curation Data
    Type
    Location
    Additional Notes
    References
    Variant Molecular Consequences
    Associated Sequence Data
    DDBJ / EMBL / GenBank
    DNA sequence
    Protein sequence
     
    UniProtKB/Swiss-Prot
      UniProtKB/TrEMBL
        Expression Data
        Reporter Expression
        distribution deduced from reporter (Gal4 UAS)
        Stage
        Tissue/Position (including subcellular localization)
        Reference
        third instar larval stage
        larval multidendritic class III neuron
        (Omamiuda-Ishikawa et al., 2020, Song et al., 2015)
        Additional Information
        Statement
        Reference

        Drives expression in larval multidendritic class III neurons.

        (FlyBase Curators, 2017)
         
        Marker for
        larval multidendritic class III neuron
        (Omamiuda-Ishikawa et al., 2020)
        Reflects expression of
        Reporter construct used in assay
        Human Disease Associations
        Disease Ontology (DO) Annotations
        Models Based on Experimental Evidence ( 0 )
        Disease
        Evidence
        References
        Modifiers Based on Experimental Evidence ( 0 )
        Disease
        Interaction
        References
        Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
         
        Disease-implicated variant(s)
         
        Phenotypic Data
        Phenotypic Class

        abnormal behavior | larval stage, with Crei\ChR1::Crei\ChR2::Vcar\ChR1::Vcar\ChR2Aurora.20xUAS.mCer3

        (Himmel et al., 2023)

        abnormal behavior | larval stage, with Crei\ChR2CHETA(E123T.H134R).UAS.YFP

        (Himmel et al., 2023)

        abnormal cold stress response | larval stage, with Ncc69JF03097

        (Himmel et al., 2023)

        abnormal cold stress response | larval stage, with Ncc69UAS.Tag:HA

        (Himmel et al., 2023)

        abnormal cold stress response | larval stage, with subduedGD3674

        (Himmel et al., 2023)

        abnormal cold stress response | larval stage, with wwkHMJ23639

        (Himmel et al., 2023)

        abnormal cold stress response | larval stage, with wwkJF03065

        (Himmel et al., 2023)

        abnormal locomotor behavior | larval stage, with Ctet\tetXTNT-LC.UAS

        (Jovanic et al., 2019)

        abnormal locomotor behavior | larval stage, with Ctet\tetXTNT-LC.UAS, Scer\GAL4GMR61D08

        (Jovanic et al., 2019)

        abnormal locomotor behavior | larval stage | chemical conditional, with Ctet\tetXTNT-LC.UAS

        (Lopez-Bellido et al., 2019)

        abnormal locomotor behavior | larval stage | conditional, with Cnoc\ChR1::Csub\ChRCsChrimson.IVS.20xUAS.Venus, Scer\GAL80tsh-md621-GAL80

        (Hu et al., 2017)

        abnormal locomotor behavior | larval stage | heat sensitive, with Scer\GAL4ppk.PG, shi1.UAS

        (Takagi et al., 2017)

        abnormal locomotor behavior | larval stage | heat sensitive, with Scer\GAL80repo.PL, shi1.UAS

        (Takagi et al., 2017)

        abnormal neuroanatomy, with TER94E375Q.E575Q.UAS

        (Rumpf et al., 2011)

        abnormal neuroanatomy, with TER94GD9777

        (Rumpf et al., 2011)

        abnormal neuroanatomy | larval stage, with GM130UAS.cZa

        (Zhou et al., 2014)

        abnormal neuroanatomy | larval stage | conditional, with Cdk1T14A.Y15F.UASp.Venus

        (Li et al., 2021)

        abnormal neuroanatomy | larval stage | conditional, with ClaspinGD10835

        (Li et al., 2021)

        abnormal neuroanatomy | larval stage | conditional, with ClaspinHMS00772

        (Li et al., 2021)

        abnormal neuroanatomy | larval stage | conditional, with grpJF02588

        (Li et al., 2021)

        abnormal neuroanatomy | larval stage | conditional, with grpKK108548

        (Li et al., 2021)

        abnormal neuroanatomy | larval stage | conditional, with mei-41KK101792

        (Li et al., 2021)

        abnormal neuroanatomy | larval stage | conditional, with mus101GD7216

        (Li et al., 2021)

        abnormal neuroanatomy | larval stage | conditional, with mus304GD4217

        (Li et al., 2021)

        abnormal neuroanatomy | larval stage | conditional, with mus304HMJ23247

        (Li et al., 2021)

        abnormal neuroanatomy | larval stage | conditional, with Rad1GD4180

        (Li et al., 2021)

        abnormal neuroanatomy | larval stage | conditional, with Rad1KK100951

        (Li et al., 2021)

        abnormal neuroanatomy | larval stage | conditional, with Rad17GD4236

        (Li et al., 2021)

        abnormal neuroanatomy | larval stage | conditional, with Rad17KK101000

        (Li et al., 2021)

        abnormal neuroanatomy | larval stage | conditional, with stgUAS.cUa

        (Li et al., 2021)

        abnormal neuroanatomy | larval stage | conditional, with tweUAS.ORF

        (Li et al., 2021)

        abnormal neuroanatomy | pupal stage, with BacA\p35UAS.cHa

        (Rumpf et al., 2011)

        abnormal neuroanatomy | third instar larval stage, with Df(1)C128, fs(1)hKK101585

        (Bagley et al., 2014)

        abnormal neuroanatomy | third instar larval stage, with fs(1)hGD4452

        (Bagley et al., 2014)

        abnormal neuroanatomy | third instar larval stage, with fs(1)hKK101585

        (Bagley et al., 2014)

        abnormal neurophysiology | larval stage, with Ncc69UAS.Tag:HA

        (Himmel et al., 2023)

        abnormal neurophysiology | larval stage, with subduedGD3674

        (Himmel et al., 2023)

        abnormal neurophysiology | larval stage, with wwkHMJ23639

        (Himmel et al., 2023)

        abnormal neurophysiology | third instar larval stage, with fs(1)hGD4452

        (Bagley et al., 2014)

        abnormal pain response | larval stage, with Ctet\tetXTNT-LC.UAS, Scer\GAL80tsh-md621-GAL80

        (Hu et al., 2017)

        abnormal pain response | larval stage, with Hsap\KCNJ2UAS.EGFP, Scer\GAL80tsh-md621-GAL80

        (Hu et al., 2017)

        abnormal touch perception | third instar larval stage, with fs(1)hGD4452

        (Bagley et al., 2014)

        abnormal touch response | larval stage | heat sensitive, with Scer\GAL4ppk.PG, shi1.UAS

        (Takagi et al., 2017)

        abnormal touch response | larval stage | heat sensitive, with Scer\GAL80repo.PL, shi1.UAS

        (Takagi et al., 2017)

        decreased cell death | pupal stage, with BacA\p35UAS.cHa

        (Rumpf et al., 2011)

        decreased cell death | pupal stage, with TER94E375Q.E575Q.UAS

        (Rumpf et al., 2011)

        decreased cell death | pupal stage, with TER94GD9777

        (Rumpf et al., 2011)

        increased cell death | pupal stage, with TER94UAS.cRb

        (Rumpf et al., 2011)

        increased cell growth rate | second instar larval stage | conditional, with RtcaGD11205, Scer\GAL80repo.PL

        (Song et al., 2015)

        increased cell growth rate | second instar larval stage | conditional, with Scer\GAL80repo.PL, Xbp1UAS.RB

        (Song et al., 2015)
        Phenotype Manifest In

        axon | larval stage | conditional, with Cdk1T14A.Y15F.UASp.Venus

        (Li et al., 2021)

        axon | larval stage | conditional, with ClaspinGD10835

        (Li et al., 2021)

        axon | larval stage | conditional, with ClaspinHMS00772

        (Li et al., 2021)

        axon | larval stage | conditional, with grpJF02588

        (Li et al., 2021)

        axon | larval stage | conditional, with grpKK108548

        (Li et al., 2021)

        axon | larval stage | conditional, with mei-41KK101792

        (Li et al., 2021)

        axon | larval stage | conditional, with mus101GD7216

        (Li et al., 2021)

        axon | larval stage | conditional, with mus304GD4217

        (Li et al., 2021)

        axon | larval stage | conditional, with mus304HMJ23247

        (Li et al., 2021)

        axon | larval stage | conditional, with Rad1GD4180

        (Li et al., 2021)

        axon | larval stage | conditional, with Rad1KK100951

        (Li et al., 2021)

        axon | larval stage | conditional, with Rad17GD4236

        (Li et al., 2021)

        axon | larval stage | conditional, with Rad17KK101000

        (Li et al., 2021)

        axon | larval stage | conditional, with stgUAS.cUa

        (Li et al., 2021)

        axon | larval stage | conditional, with tweUAS.ORF

        (Li et al., 2021)

        dendrite, with GM130UAS.cZa

        (Zhou et al., 2014)

        dendrite, with TER94E375Q.E575Q.UAS

        (Rumpf et al., 2011)

        dendrite, with TER94GD9777

        (Rumpf et al., 2011)

        dendrite | third instar larval stage, with Df(1)C128, fs(1)hKK101585

        (Bagley et al., 2014)

        dendrite | third instar larval stage, with fs(1)hGD4452

        (Bagley et al., 2014)

        dendrite | third instar larval stage, with fs(1)hKK101585

        (Bagley et al., 2014)

        dendritic arborizing neuron | larval stage, with GM130UAS.cZa

        (Zhou et al., 2014)

        dendritic branch point, with GM130UAS.cZa

        (Zhou et al., 2014)

        Golgi apparatus, with GM130UAS.cZa

        (Zhou et al., 2014)

        larval multidendritic class III neuron, with BacA\p35UAS.cHa

        (Rumpf et al., 2011)

        larval multidendritic class III neuron, with Ncc69UAS.Tag:HA

        (Himmel et al., 2023)

        larval multidendritic class III neuron, with subduedGD3674

        (Himmel et al., 2023)

        larval multidendritic class III neuron, with TER94E375Q.E575Q.UAS

        (Rumpf et al., 2011)

        larval multidendritic class III neuron, with TER94GD9777

        (Rumpf et al., 2011)

        larval multidendritic class III neuron, with wwkHMJ23639

        (Himmel et al., 2023)

        larval multidendritic class III neuron | conditional, with Cdk1T14A.Y15F.UASp.Venus

        (Li et al., 2021)

        larval multidendritic class III neuron | conditional, with ClaspinGD10835

        (Li et al., 2021)

        larval multidendritic class III neuron | conditional, with ClaspinHMS00772

        (Li et al., 2021)

        larval multidendritic class III neuron | conditional, with grpJF02588

        (Li et al., 2021)

        larval multidendritic class III neuron | conditional, with grpKK108548

        (Li et al., 2021)

        larval multidendritic class III neuron | conditional, with mei-41KK101792

        (Li et al., 2021)

        larval multidendritic class III neuron | conditional, with mus101GD7216

        (Li et al., 2021)

        larval multidendritic class III neuron | conditional, with mus304GD4217

        (Li et al., 2021)

        larval multidendritic class III neuron | conditional, with mus304HMJ23247

        (Li et al., 2021)

        larval multidendritic class III neuron | conditional, with Rad1GD4180

        (Li et al., 2021)

        larval multidendritic class III neuron | conditional, with Rad1KK100951

        (Li et al., 2021)

        larval multidendritic class III neuron | conditional, with Rad17GD4236

        (Li et al., 2021)

        larval multidendritic class III neuron | conditional, with Rad17KK101000

        (Li et al., 2021)

        larval multidendritic class III neuron | conditional, with stgUAS.cUa

        (Li et al., 2021)

        larval multidendritic class III neuron | conditional, with tweUAS.ORF

        (Li et al., 2021)

        larval multidendritic class III neuron | larval stage, with GM130UAS.cZa

        (Zhou et al., 2014)

        larval multidendritic class III neuron | third instar larval stage, with Df(1)C128, fs(1)hKK101585

        (Bagley et al., 2014)

        larval multidendritic class III neuron | third instar larval stage, with fs(1)hGD4452

        (Bagley et al., 2014)

        larval multidendritic class III neuron | third instar larval stage, with fs(1)hKK101585

        (Bagley et al., 2014)

        microtubule, with GM130UAS.cZa

        (Zhou et al., 2014)
        Detailed Description
        Statement
        Reference

        Inhibition (using Ctet\TeTxLC[TNT.UAS]) of Scer\GAL419-12 neurons in larvae slightly reduces navigation away from higher wind speeds, compared to controls, with no effect on movement speed in the absense of wind stimuli; there is no effect on the probability of head turns downwind or acceptance rates of head sweeps away from versus towards the wind, compared to controls.

        Inhibition (using Ctet\TeTxLC[TNT.UAS]) of the combined set of Scer\GAL4GMR61D08 and Scer\GAL419-12 neurons in larvae significantly reduces navigation away from higher wind speeds, compared to controls; this effect is significantly greater than that of inhibiting Scer\GAL419-12 neurons alone; there is also a significant reduction in the probability of head turns downwind and acceptance rates of head sweeps away from versus towards the wind, compared to controls and compared to Scer\GAL419-12 neurons alone.

        (Jovanic et al., 2019)

        Inhibition (using Ctet\tetXTNT-LC.UAS) of Scer\GAL419-12 cells significantly reduces larval escape behavior in response to HCl application, compared to controls.

        (Lopez-Bellido et al., 2019)

        Inhibition (using Ctet\tetXTNT-LC.UAS or Hsap\KCNJ2UAS.EGFP) of a subset of Scer\GAL419-12 cells (inhibition restricted using Scer\GAL80tsh-GAL80) in larvae significantly reduces nociceptive movement responses following stimulation with a von Frey filament, compared to controls.

        Optogenetic activation (using Cnoc\ChR1::Csub\ChRCsChrimson.IVS.20xUAS.Venus with 625 nm (red) light) of a subset of Scer\GAL419-12 cells (activation restricted using Scer\GAL80tsh-GAL80) in larvae results in contractions without rolling in the absence of pain stimuli, this is not seen in controls.

        (Hu et al., 2017)

        Inhibition (using shi1.UAS at 31[o]C) of Scer\GAL419-12 cells in larvae, further restricted using Scer\GAL80repo.PL, or inhibition of the combined set of Scer\GAL4ppk.PG and Scer\GAL419-12 cells, significantly reduces the probability of backwards motion in response to a head touch, compared to controls.

        (Takagi et al., 2017)
        External Data
        Interactions
        Show genetic interaction network for Enhancers & Suppressors
        Phenotypic Class
        Suppressed by
        Statement
        Reference

        Scer\GAL419-12, TER94E375Q.E575Q.UAS has decreased cell death | pupal stage phenotype, suppressible by Diap14/th[+]

        (Rumpf et al., 2011)
        Suppressor of
        Statement
        Reference

        Scer\GAL419-12/tweHMS00642 is a suppressor of abnormal neuroanatomy | larval stage | conditional phenotype of mei-4129D

        (Li et al., 2021)
        NOT Suppressor of
        Statement
        Reference

        Scer\GAL419-12/NosUAS.cLa is a non-suppressor of abnormal neuroanatomy | larval stage | conditional phenotype of mei-4129D

        (Li et al., 2021)

        Scer\GAL419-12/Mmus\Piezo1TriM.UAS is a non-suppressor of abnormal neuroanatomy | larval stage | conditional phenotype of mei-4129D

        (Li et al., 2021)
        Phenotype Manifest In
        Suppressor of
        Statement
        Reference

        Scer\GAL419-12/tweHMS00642 is a suppressor of axon | larval stage | conditional phenotype of mei-4129D

        (Li et al., 2021)

        Scer\GAL419-12/tweHMS00642 is a suppressor of larval multidendritic class III neuron phenotype of mei-4129D

        (Li et al., 2021)
        NOT Suppressor of
        Statement
        Reference

        Scer\GAL419-12/Mmus\Piezo1TriM.UAS is a non-suppressor of axon | larval stage | conditional phenotype of mei-4129D

        (Li et al., 2021)

        Scer\GAL419-12/Mmus\Piezo1TriM.UAS is a non-suppressor of larval multidendritic class III neuron | conditional phenotype of mei-4129D

        (Li et al., 2021)

        Scer\GAL419-12/NosUAS.cLa is a non-suppressor of axon | larval stage | conditional phenotype of mei-4129D

        (Li et al., 2021)

        Scer\GAL419-12/NosUAS.cLa is a non-suppressor of larval multidendritic class III neuron | conditional phenotype of mei-4129D

        (Li et al., 2021)
        Additional Comments
        Genetic Interactions
        Statement
        Reference
        Xenogenetic Interactions
        Statement
        Reference
        Complementation and Rescue Data
        Images (0)
        Mutant
        Wild-type
        Stocks (0)
        Notes on Origin
        Discoverer
        External Crossreferences and Linkouts ( 0 )
        Synonyms and Secondary IDs (3)
        References (41)