FlyBase Allele Report: Dmel\holn1[KK100428]

General Information

Symbol

Dmel\holn1^KK100428

Species

D. melanogaster

Name

FlyBase ID

FBal0258756

Feature type

allele

Associated gene

Dmel\holn1

Associated Insertion(s)

Carried in Construct

P{KK100428}

Key Links

Genomic Maps

JBrowse

Transgenic product class

RNAi_reagent

(Keleman et al., 2009.8.5)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

RNAi_reagent

(Keleman et al., 2009.8.5)

Mutagen

in vitro construct

(Keleman et al., 2009.8.5)

Progenitor genotype

Carried in construct

P{KK100428}

Cytology

Description

UASt regulatory sequences drive expression of an inverted repeat.

(Keleman et al., 2009.8.5)

Allele components

Component

Use(s)

Regulatory region(s)

UASt

binary expression system - regulatory region

Encoded product / tool

dsRNA-KK100428

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

lethal - all die before end of pupal stage, with Scer\GAL4^Act5C.PU

(Geiger et al., 2011)

some die during pupal stage, with Scer\GAL4^Act5C.PU

(Geiger et al., 2011)

Phenotype Manifest In

wing, with Scer\GAL4^Bx-MS1096

(Geiger et al., 2011)

wing vein | ectopic, with Scer\GAL4^Bx-MS1096

(Geiger et al., 2011)

Detailed Description

Statement

Reference

Expression of holn1^KK100428 using Scer\GAL4^Bx-MS1096 results in a range of phenotypes, from wild-type looking to a smaller, cylindrically curved wing with an increased number of veins, or a blistered wing with much of the surface converted to vein material.

Expression of holn1^KK100428 using Scer\GAL4^Act5C.PU results in late pupal lethality.

(Geiger et al., 2011)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Phenotype Manifest In

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (1)

VDRC

v110281

P{KK100428}VIE-260B

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

CG5198^KK100428

holn1^KK100428

Name Synonyms

Secondary FlyBase IDs

References (2)

Report Sections

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