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General Information
Symbol
Dmel\l(2)glKK100777
Species
D. melanogaster
Name
FlyBase ID
FBal0258819
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Allele class
Nature of the Allele
Allele class
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Carried in construct
Cytology
Nature of the lesion
Statement
Reference

UASt regulatory sequences drive expression of an inverted repeat.

Allele components
Product class / Tool use(s)
Encoded product / tool
Associated Sequence Features
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 1 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

Expression of l(2)glKK100777 under the control of Scer\GAL4Bx-MS1096 or Scer\GAL4Hml.Δ does not lead to a significant difference in survival as compared to controls when larvae are infected with the nematode Heterorhabditis bacteriophora and its associated bacterium Photorhabdus luminescens.

Expression of l(2)glKK100777 (driven by Scer\GAL4Dll-md23) in MARCM clones in the antennal discs in third instar larvae leads to tumorigenic overgrowth, while in the type II neuroblast lineage clones it results in supernumerary neuroblasts but the clones are smaller than the wild-type control clones.

Scer\GAL4tj-NP1624-mediated expression results in the transformation of the normal germline cyst epithelial monolayer into two or more cell layers. Individual cells or cell clusters seem to ingress into the cyst.

Expression of l(2)glKK100777 (co-expressed with Dcr-2Scer\UAS.cDa) under the control of Scer\GAL4repo.PU has no detectable effect on glial cell number in the third instar larval eye disc.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Phenotype Manifest In
Additional Comments
Genetic Interactions
Statement
Reference

Co-expression of l(2)glKK100777 exacerbates the increased hemocyte count observed in larvae expressing Ras85DV12.Scer\UAS under the control of Scer\GAL4Hml.Δ; these larvae are viable up to pupal stage and prepare for pupation, but only a subset of these pupae successfully eclose at 25[o]C, as compared to controls. None of these flies eclose when reared at 29[o]C, and pupae exhibit dessication and an absence of precursors of adult structures, in contrast to controls.

Larvae expressing both Ras85DV12.Scer\UAS and l(2)glKK100777 under the control of Scer\GAL4Hml.Δ exhibit no significant difference in wound healing; larvae wounded and infected with the bacteria Staphylococcus aureus, Erwinia carotovora, or E.coli survive equally well as controls; and hemocytes isolated from larvae exhibit normal phagocytosis levels upon exposure to to heat killed E. coli, as compared to controls.

Larvae expressing both Ras85DV12.Scer\UAS and l(2)glKK100777 under the control of Scer\GAL4Bx-MS1096 infected with the nematode Heterorhabditis bacteriophora and its associated bacterium Photorhabdus luminescens, do not show a significant difference in survival as compared to controls; but when these constructs are driven under the control of Scer\GAL4Hml.Δ, infected larvae show a significant increase in mortality as compared to controls, and also show a similar decrease in motility upon nematode infection as seen in those expressing only Ras85DV12.Scer\UAS.

The tumor-like overgrowth of MARCM clones in larval antennal disc expressing l(2)glKK100777 under the control of Scer\GAL4Dll-md23 is not significantly worsened by cnoR2 homozygosity but the cellular and tissue morphology and disorganization are exacerbated.

The decreased size of neuroblasts in the cnoR2 type II neuroblast lineage MARCM clones is not affected by expression of l(2)glKK100777 (driven by Scer\GAL4Dll-md23) in the clones.

Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Comments
Images (0)
Mutant
Wild-type
Stocks (1)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (1)
Reported As
Symbol Synonym
l(2)glKK100777
Name Synonyms
Secondary FlyBase IDs
    References (5)