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General Information
Symbol
Dmel\α-SpecKK101541
Species
D. melanogaster
Name
FlyBase ID
FBal0258977
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Allele class
Nature of the Allele
Allele class
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Carried in construct
Cytology
Nature of the lesion
Statement
Reference

UASt regulatory sequences drive expression of an inverted repeat.

Allele components
Product class / Tool use(s)
Encoded product / tool
Associated Sequence Features
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

Scer\GAL4tj-NP1624-mediated expression results in the transformation of the normal germline cyst epithelial monolayer into two or more cell layers.

Expression of α-SpecKK101541 under the control of Scer\GAL4elav.PU results in synaptic retractions in 47% of muscle 6/7 synapses.

Expression of α-SpecKK101541 under the control of Scer\GAL4elav-C155 results in synaptic degeneration.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Phenotype Manifest In
Additional Comments
Genetic Interactions
Statement
Reference

The synaptic retraction phenotype seen at the neuromuscular junction in larvae expressing α-SpecKK101541 under the control of Scer\GAL4elav.PU is suppressed by SkpAGD65.

Expression of bskK53R.Scer\UAS enhances the synaptic degeneration phenotype seen when α-SpecKK101541 is expressed under the control of Scer\GAL4elav-C155.

Homozygous MiroB682 suppresses the neuromuscular degeneration seen when α-SpecKK101541 is expressed under the control of Scer\GAL4elav-C155. The decrease in the number of mitochondria seen in MiroB682 mutants is also seen in these larvae.

Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Comments
Images (0)
Mutant
Wild-type
Stocks (1)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (1)
Reported As
Symbol Synonym
α-SpecKK101541
Name Synonyms
Secondary FlyBase IDs
    References (4)