FB2025_01 , released February 20, 2025
Allele: Dmel\Ercc1KK101553
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General Information
Symbol
Dmel\Ercc1KK101553
Species
D. melanogaster
Name
FlyBase ID
FBal0258979
Feature type
allele
Associated gene
Dmel\Ercc1
Associated Insertion(s)
Carried in Construct
P{KK101553}
Key Links
Genomic Maps

Transgenic product class
RNAi_reagent
(Keleman et al., 2009.8.5)
Mutagen
Nature of the Allele
Transgenic product class
RNAi_reagent
(Keleman et al., 2009.8.5)
Mutagen
in vitro construct
(Keleman et al., 2009.8.5)
Progenitor genotype
Carried in construct
P{KK101553}
Cytology
Description

UASt regulatory sequences drive expression of an inverted repeat.

(Keleman et al., 2009.8.5)
Allele components
Component
Use(s)
Regulatory region(s)
UASt
Encoded product / tool
dsRNA-KK101553
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Enhancer of
      Suppressor of
      NOT Suppressor of
      Statement
      Reference

      Ercc1KK101553, Scer\GAL4A58 is a non-suppressor of adult abdomen | conditional phenotype of Scer\GAL4A58, mei-9RNAi.UAS

      (Mlih et al., 2018)
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      In adults expressing mei-9dsRNA.UAS under the control of Scer\GAL4Act88F.1.3, longitudinal thoracic muscles exhibit DNA damage (phospho-H2AvD staining) and premature aging (progressive loss of proteostasis); both of these are robustly enhanced by the co-expression of Ercc1KK101553, which is highlighted by a premature loss of proteostasis and disruption of myofibril muscle structure during aging. 30-days adults expressing mei-9dsRNA.UAS also present increased mitosis in the midgut, which is also suppressed by the co-expression of Ercc1KK101553.

      The UV-induced cuticle defects observed in the abdomen of adults expressing mei-9dsRNA.UAS under the control of Scer\GAL4A58 are not suppressed by the co-expression of Ercc1KK101553.

      (Mlih et al., 2018)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (1)
      Reported As
      Symbol Synonym
      Ercc1KK101553
      Name Synonyms
      Secondary FlyBase IDs
        References (2)