FB2025_05 , released December 11, 2025
Allele: Dmel\MICU1KK101920
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General Information
Symbol
Dmel\MICU1KK101920
Species
D. melanogaster
Name
FlyBase ID
FBal0259042
Feature type
allele
Associated gene
Dmel\MICU1
Associated Insertion(s)
Carried in Construct
P{KK101920}
Key Links
Genomic Maps

Transgenic product class
RNAi_reagent
(Keleman et al., 2009.8.5)
Mutagen
Nature of the Allele
Transgenic product class
RNAi_reagent
(Keleman et al., 2009.8.5)
Mutagen
in vitro construct
(Keleman et al., 2009.8.5)
Progenitor genotype
Carried in construct
P{KK101920}
Cytology
Description

UASt regulatory sequences drive expression of an inverted repeat.

(Keleman et al., 2009.8.5)
Allele components
Component
Use(s)
Regulatory region(s)
UASt
Encoded product / tool
dsRNA-KK101920
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Expression of MICU1KK101920, with UAS-Dicer2 to enhance RNAi efficiency, driven by Scer\GAL4Act.PU or Scer\GAL4tub.PU results in lethality before adulthood.

      Expression of MICU1KK101920, with UAS-Dicer2 to enhance RNAi efficiency, driven by Scer\GAL4GMR13F02 impairs adult olfactory intermediate-term memory (but not olfactory avoidance, shock avoidance, learning, or immediate or long-term memory) as compared to controls; the impairment persists after either anesthesia-sensitive memory elimination by cold-shock treatment or 5-times massed training.

      Expression of MICU1KK101920, with UAS-Dicer2 to enhance RNAi efficiency, driven by Scer\GAL4GMR13F02 and temporally-limited by Gal80[ts] to pre-adult developing stages, but not to adulthood, impairs adult olfactory intermediate-term memory in olfactory aversive tests (but not olfactory avoidance, shock avoidance or learning) as compared to controls.

      Expression of MICU1KK101920, with UAS-Dicer2 to enhance RNAi efficiency, driven by either Scer\GAL4Tab2-201Y or Scer\GAL4GMR25H11 impairs adult olfactory intermediate-term memory (but not odor avoidance or shock avoidance) as compared to controls.

      (Drago and Davis, 2016)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      CG4495KK101920
      MICU1KK101920
      Name Synonyms
      Secondary FlyBase IDs
        References (2)