FlyBase Allele Report: Dmel\mor[KK102003]

General Information

Symbol

Dmel\mor^KK102003

Species

D. melanogaster

Name

FlyBase ID

FBal0259076

Feature type

allele

Associated gene

Dmel\mor

Associated Insertion(s)

Carried in Construct

P{KK102003}

Key Links

Genomic Maps

JBrowse

Transgenic product class

RNAi_reagent

(Keleman et al., 2009.8.5)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

RNAi_reagent

(Keleman et al., 2009.8.5)

Mutagen

in vitro construct

(Keleman et al., 2009.8.5)

Progenitor genotype

Carried in construct

P{KK102003}

Cytology

Description

UASt regulatory sequences drive expression of an inverted repeat.

(Keleman et al., 2009.8.5)

Allele components

Component

Use(s)

Regulatory region(s)

UASt

binary expression system - regulatory region

Encoded product / tool

dsRNA-KK102003

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 1 )

Disease

Evidence

References

model of Coffin-Siris syndrome

CEA

(Chubak et al., 2019)

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal size | adult stage, with Scer\GAL4^ey.PH

(Dietz et al., 2015)

lethal, with Scer\GAL4^Act5C.PI

(Dietz et al., 2015)

lethal, with Scer\GAL4^en.PU

(Dietz et al., 2015)

lethal, with Scer\GAL4^nub.PK

(Dietz et al., 2015)

partially lethal - majority die, with Scer\GAL4^ey.PH

(Dietz et al., 2015)

visible, with Scer\GAL4^Bx-MS1096

(Schertel et al., 2015)

visible | adult stage, with Scer\GAL4^en.PU

(Dietz et al., 2015)

visible | adult stage, with Scer\GAL4^ey.PH

(Dietz et al., 2015)

visible | adult stage, with Scer\GAL4^nub.PK

(Dietz et al., 2015)

Phenotype Manifest In

eye, with Scer\GAL4^ey.PH

(Dietz et al., 2015)

wing, with Scer\GAL4^Bx-MS1096

(Schertel et al., 2015)

wing blade, with Scer\GAL4^en.PU

(Dietz et al., 2015)

wing blade, with Scer\GAL4^nub.PK

(Dietz et al., 2015)

Detailed Description

Statement

Reference

Expression of mor^KK102003 is pupal lethal at 25[o]C when driven by Scer\GAL4^Act5C.PI, Scer\GAL4^nub.PK (also lethal at 18[o]C), Scer\GAL4^en.PU (leads to crinkled and blistered wings at 18[o]C) or Scer\GAL4^ey.PH (with escapers showing small deformed eyes, a phenotype also displayed by the flies kept at 18[o]C). No overt adult phenotype is observed with the Scer\GAL4^GMR.PF driver.

(Dietz et al., 2015)

Expression of mor^KK102003 under the control of Scer\GAL4^Bx-MS1096 results in male flies with almost complete wing loss.

Expression of mor^KK102003 under the control of Scer\GAL4^Bx-MS1096 results in female flies with severe wing size and patterning defects.

(Schertel et al., 2015)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Phenotype Manifest In

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (1)

VDRC

v110712

P{KK102003}VIE-260B

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

MOR^KD

(Tilly et al., 2021)

mor^KK102003

Name Synonyms

Secondary FlyBase IDs

References (9)

Report Sections

Open Close