FlyBase Allele Report: Dmel\Xbp1[KK102632]

General Information

Symbol

Dmel\Xbp1^KK102632

Species

D. melanogaster

Name

FlyBase ID

FBal0259205

Feature type

allele

Associated gene

Dmel\Xbp1

Associated Insertion(s)

Carried in Construct

P{KK102632}

Key Links

Genomic Maps

JBrowse

Transgenic product class

RNAi_reagent

(Keleman et al., 2009.8.5)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

RNAi_reagent

(Keleman et al., 2009.8.5)

Mutagen

in vitro construct

(Keleman et al., 2009.8.5)

Progenitor genotype

Carried in construct

P{KK102632}

Cytology

Description

UASt regulatory sequences drive expression of an inverted repeat.

(Keleman et al., 2009.8.5)

Allele components

Component

Use(s)

Regulatory region(s)

UASt

binary expression system - regulatory region

Encoded product / tool

dsRNA-KK102632

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 1 )

Disease

Interaction

References

exacerbates prion disease

modeled by Hsap\PRNP^V129.UAS.att

(Myers et al., 2022)

exacerbates Alzheimer's disease 1

modeled by Hsap\APP^{Arctic.UAS.Tag:SS(nec)}

(Catterson et al., 2023)

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal starvation stress response | adult stage, with Scer\GAL4^Cg.PA

(Zhao et al., 2021)

decreased cell size | larval stage | somatic clone, with Scer\GAL4^Act.PU

(Zhao et al., 2021)

decreased size | adult stage, with Scer\GAL4^Cg.PA

(Zhao et al., 2021)

decreased size | larval stage | somatic clone, with Scer\GAL4^Act.PU

(Zhao et al., 2021)

increased cell number | adult stage | somatic clone, with Scer\GAL4^unspecified

(Wang et al., 2014)

increased mortality | adult stage, with Scer\GAL4^Cg.PA

(Zhao et al., 2021)

Phenotype Manifest In

larval fat cell | somatic clone, with Scer\GAL4^Act.PU

(Zhao et al., 2021)

lipid droplet | adult stage, with Scer\GAL4^Cg.PA

(Zhao et al., 2021)

lipid droplet | larval stage | somatic clone, with Scer\GAL4^Act.PU

(Zhao et al., 2021)

midgut | adult stage, with Scer\GAL4^NP0001

(Wang et al., 2014)

midgut | adult stage, with Scer\GAL4^NP5130, Scer\GAL80^Su(H).GBE

(Wang et al., 2014)

midgut | adult stage, with Scer\GAL4^Su(H).GBE

(Wang et al., 2014)

midgut | adult stage | somatic clone, with Scer\GAL4^unspecified

(Wang et al., 2014)

Detailed Description

Statement

Reference

The expression of Xbp1^KK102632 under the control of Scer\GAL4^GMR.long does not induce any obvious eye phenotype (overall morphology, ommatidial array, interommatidial bristles), as compared to controls.

(Yan et al., 2019)

The temporally regulated expression (by Gal80[ts]) of Xbp1^KK102632, for 5 days under the control of Scer\GAL4^NP0001, or for 6 days Scer\GAL4[unspecified]under the control of Scer\GAL4^NP5130, under the control of Scer\GAL4^Su(H).GBE, under the combined control of Scer\GAL4^NP5130 and Scer\GAL80^Su(H).GBE, leads to a strong increase in the proportion of mitotic cells in the adults midgut, as compared to controls. Adult midgut clones expressing Xbp1^KK102632 under the control of Scer\GAL4^unspecified exhibit a significantly increased cell number at 7 days after clone induction, as compared to control clones. or in clones under the control of Scer\GAL4^Act.PU.

(Wang et al., 2014)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhanced by

Statement

Reference

LanB1^UAS.mRFP1, Scer\GAL4^GMR.PFa, Xbp1^KK102632 has visible | adult stage phenotype, enhanceable by Hsap\APP^2xAPP.SP.UAS, Scer\GAL4^GMR.PFa

(Catterson et al., 2023)

Suppressed by

Statement

Reference

Scer\GAL4^Act.PU, Xbp1^KK102632 has decreased cell size | somatic clone | larval stage phenotype, suppressible by Scer\GAL4^Act.PU/foxo^KK108590

(Zhao et al., 2021)

Scer\GAL4^Cg.PA, Xbp1^KK102632 has abnormal starvation stress response | adult stage phenotype, suppressible | partially by foxo^KK108590/Scer\GAL4^Cg.PA

(Zhao et al., 2021)

Scer\GAL4^Cg.PA, Xbp1^KK102632 has increased mortality | adult stage phenotype, suppressible | partially by foxo^KK108590/Scer\GAL4^Cg.PA

(Zhao et al., 2021)

Scer\GAL4^Cg.PA, Xbp1^KK102632 has decreased size | adult stage phenotype, suppressible | partially by foxo^KK108590/Scer\GAL4^Cg.PA

(Zhao et al., 2021)

Scer\GAL4^Act.PU, Xbp1^KK102632 has decreased size | somatic clone | larval stage phenotype, suppressible by Scer\GAL4^Act.PU/foxo^KK108590

(Zhao et al., 2021)

Scer\GAL4^unspecified, Xbp1^KK102632 has increased cell number | somatic clone | adult stage phenotype, suppressible | somatic clone by Keap1^EY5

(Wang et al., 2014)

Enhancer of

Statement

Reference

Xbp1^KK102632, Scer\GAL4^GMR.PFa is an enhancer of visible | adult stage phenotype of Hsap\APP^2xAPP.SP.UAS, Scer\GAL4^GMR.PFa

(Catterson et al., 2023)

Xbp1^KK102632, Scer\GAL4^GMR.PFa is an enhancer of decreased size | adult stage phenotype of Hsap\APP^2xAPP.SP.UAS, Scer\GAL4^GMR.PFa

(Catterson et al., 2023)

Xbp1^KK102632, Scer\GAL4^GS.nSyb.PB is an enhancer of short lived | RU486 conditional phenotype of Hsap\APP^{Arctic.UAS.Tag:SS(nec)}, Scer\GAL4^GS.nSyb.PB

(Catterson et al., 2023)

Xbp1^KK102632, Scer\GAL4^GMR.PU is an enhancer of visible | adult stage phenotype of Hsap\PRNP^V129.UAS, Scer\GAL4^GMR.PU

(Myers et al., 2022)

Xbp1^KK102632, Scer\GAL4^GMR.long is an enhancer of visible | adult stage phenotype of Ire1^UAS.Tag:V5, Scer\GAL4^GMR.long

(Yan et al., 2019)

NOT Suppressor of

Statement

Reference

Xbp1^KK102632, Scer\GAL4^GMR.long is a non-suppressor of increased cell death | third instar larval stage phenotype of Ire1^UAS.Tag:V5, Scer\GAL4^GMR.long

(Yan et al., 2019)

Scer\GAL4^unspecified/Xbp1^KK102632 is a non-suppressor | somatic clone of decreased cell number | somatic clone | adult stage phenotype of Keap1^EY5

(Wang et al., 2014)

Other

Statement

Reference

LanB1^UAS.mRFP1, Scer\GAL4^GMR.PFa, Xbp1^KK102632 has visible | adult stage phenotype

(Catterson et al., 2023)

Hsap\PRNP^V129.UAS, Scer\GAL4^GMR.PU, Xbp1^KK102632 has decreased size | adult stage phenotype

(Myers et al., 2022)

Phenotype Manifest In

Enhanced by

Statement

Reference

LanB1^UAS.mRFP1, Scer\GAL4^GMR.PFa, Xbp1^KK102632 has eye phenotype, enhanceable by Hsap\APP^2xAPP.SP.UAS, Scer\GAL4^GMR.PFa

(Catterson et al., 2023)

Suppressed by

Statement

Reference

Scer\GAL4^Cg.PA, Xbp1^KK102632 has lipid droplet | adult stage phenotype, suppressible | partially by foxo^KK108590/Scer\GAL4^Cg.PA

(Zhao et al., 2021)

Scer\GAL4^Act.PU, Xbp1^KK102632 has lipid droplet | somatic clone | larval stage phenotype, suppressible by Scer\GAL4^Act.PU/foxo^KK108590

(Zhao et al., 2021)

Scer\GAL4^Act.PU, Xbp1^KK102632 has larval fat cell | somatic clone phenotype, suppressible by Scer\GAL4^Act.PU/foxo^KK108590

(Zhao et al., 2021)

Scer\GAL4^unspecified, Xbp1^KK102632 has midgut | somatic clone | adult stage phenotype, suppressible | somatic clone by Keap1^EY5

(Wang et al., 2014)

Enhancer of

Statement

Reference

Xbp1^KK102632, Scer\GAL4^GMR.PFa is an enhancer of eye phenotype of Hsap\APP^2xAPP.SP.UAS, Scer\GAL4^GMR.PFa

(Catterson et al., 2023)

Xbp1^KK102632, Scer\GAL4^GMR.PU is an enhancer of eye phenotype of Hsap\PRNP^V129.UAS, Scer\GAL4^GMR.PU

(Myers et al., 2022)

Xbp1^KK102632, Scer\GAL4^GMR.long is an enhancer of eye phenotype of Ire1^UAS.Tag:V5, Scer\GAL4^GMR.long

(Yan et al., 2019)

Xbp1^KK102632, Scer\GAL4^GMR.long is an enhancer of ommatidium phenotype of Ire1^UAS.Tag:V5, Scer\GAL4^GMR.long

(Yan et al., 2019)

NOT Suppressor of

Statement

Reference

Xbp1^KK102632, Scer\GAL4^GMR.long is a non-suppressor of eye disc phenotype of Ire1^UAS.Tag:V5, Scer\GAL4^GMR.long

(Yan et al., 2019)

Scer\GAL4^unspecified/Xbp1^KK102632 is a non-suppressor | somatic clone of midgut | somatic clone | adult stage phenotype of Keap1^EY5

(Wang et al., 2014)

Other

Statement

Reference

LanB1^UAS.mRFP1, Scer\GAL4^GMR.PFa, Xbp1^KK102632 has eye phenotype

(Catterson et al., 2023)

Additional Comments

Genetic Interactions

Statement

Reference

The co-expression of Xbp1^KK102632 enhances the eye defects induced by the expression of Hsap\PRNP^V129.UAS under the control of Scer\GAL4^GMR.PU, even leading to a small eye.

(Myers et al., 2022)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (1)

VDRC

v109312

P{KK102632}VIE-260B

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

Xbp1^KK102632

Xbp1^RNAi109312

(Wang et al., 2015)

Name Synonyms

Secondary FlyBase IDs

References (10)

Report Sections

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