FB2025_05 , released December 11, 2025
Allele: Dmel\SypKK108062
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General Information
Symbol
Dmel\SypKK108062
Species
D. melanogaster
Name
FlyBase ID
FBal0259603
Feature type
allele
Associated gene
Dmel\Syp
Associated Insertion(s)
Carried in Construct
P{KK108062}
Key Links
Genomic Maps

Transgenic product class
RNAi_reagent
(Keleman et al., 2009.8.5)
Mutagen
Nature of the Allele
Transgenic product class
RNAi_reagent
(Keleman et al., 2009.8.5)
Mutagen
in vitro construct
(Keleman et al., 2009.8.5)
Progenitor genotype
Carried in construct
P{KK108062}
Cytology
Description

UASt regulatory sequences drive expression of an inverted repeat.

(Keleman et al., 2009.8.5)
Allele components
Component
Use(s)
Regulatory region(s)
UASt
Encoded product / tool
dsRNA-KK108062
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 1 )
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Expression of SypKK108062 under the control of Scer\GAL4GMR.PU results in a mild rough eye phenotype in adult flies, whereas expression driven by Scer\GAL4elav.PU results in complete paralysis.

      (Appocher et al., 2017)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      Adult flies expressing SypKK108062 (together with UAS-Dicer2 to enhance RNAi efficiency) under the control of Scer\GAL4elav.PU in either wild-type or TBPHΔ23/+; TBPHdsRNA.Scer\UAS.cUa background appear to be completely paralyzed.

      The eye degeneration phenotype (appearance of melanotic spots, fusion of ommatidia) characteristic for adult flies expressing TBPHScer\UAS.T:Zzzz\FLAG under the control of Scer\GAL4GMR.PU is strongly suppressed by co-expression of SypKK108062.

      (Appocher et al., 2017)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (3)
      Reported As
      Symbol Synonym
      CG17838KK108062
      SypKK108062
      SypRNAi
      (Appocher et al., 2017)
      Name Synonyms
      Secondary FlyBase IDs
        References (4)