FlyBase Allele Report: Dmel\vn[KK108432]

General Information

Symbol

Dmel\vn^KK108432

Species

D. melanogaster

Name

FlyBase ID

FBal0259676

Feature type

allele

Associated gene

Dmel\vn

Associated Insertion(s)

Carried in Construct

P{KK108432}

Key Links

Genomic Maps

JBrowse

Transgenic product class

RNAi_reagent

(Keleman et al., 2009.8.5)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

RNAi_reagent

(Keleman et al., 2009.8.5)

Mutagen

in vitro construct

(Keleman et al., 2009.8.5)

Progenitor genotype

Carried in construct

P{KK108432}

Cytology

Description

UASt regulatory sequences drive expression of an inverted repeat.

(Keleman et al., 2009.8.5)

Allele components

Component

Use(s)

Regulatory region(s)

UASt

binary expression system - regulatory region

Encoded product / tool

dsRNA-KK108432

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal learning | third instar larval stage | RU486 conditional, with Scer\GAL4^{elav.Switch.PO}

(Rahn et al., 2013)

visible, with Scer\GAL4^69B

(Austin et al., 2014)

visible, with Scer\GAL4^sd.PU

(Austin et al., 2014)

Phenotype Manifest In

anterior crossvein, with Scer\GAL4^sd.PU

(Austin et al., 2014)

wing vein, with Scer\GAL4^69B

(Austin et al., 2014)

wing vein L3, with Scer\GAL4^sd.PU

(Austin et al., 2014)

wing vein L4, with Scer\GAL4^sd.PU

(Austin et al., 2014)

Detailed Description

Statement

Reference

Flies expressing vn^KK108432 under the control of Scer\GAL4^sd.PU exhibit wing vein phenotypes. There is loss of L4, L2 and the anterior crossvein. Less severe vein loss is seen when vn^KK108432 is expressed under the control of Scer\GAL4^69B.

(Austin et al., 2014)

Expression of vn^KK108432 under the control of Scer\GAL4^{elav.Switch.PO} from immediately after hatching onwards (using mifepristone to control the timing of expression) results in significantly reduced olfactory learning ability in third instar larvae. These larvae show normal gustatory preference responses to fructose and to quinine.

(Rahn et al., 2013)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

NOT Enhanced by

Statement

Reference

Scer\GAL4^sd.PU, vn^KK108432 has visible phenotype, non-enhanceable by spi^HMS01120/Scer\GAL4^sd.PU

(Austin et al., 2014)

Scer\GAL4^sd.PU, vn^KK108432 has visible phenotype, non-enhanceable by Scer\GAL4^sd.PU/spi^JF03322

(Austin et al., 2014)

Suppressor of

Statement

Reference

Scer\GAL4^how-24B/vn^KK108432 is a suppressor of increased cell number phenotype of Scer\GAL4^how-24B, rk^GD15

(Scopelliti et al., 2014)

Scer\GAL4^how-24B/vn^KK108432 is a suppressor of increased occurrence of cell division | adult stage phenotype of Scer\GAL4^how-24B, rk^GD15

(Scopelliti et al., 2014)

Scer\GAL4^Mef2.PU/vn^KK108432 is a suppressor of increased occurrence of cell division | adult stage phenotype of Burs^Z5569

(Scopelliti et al., 2014)

Phenotype Manifest In

NOT Enhanced by

Statement

Reference

Scer\GAL4^sd.PU, vn^KK108432 has wing vein phenotype, non-enhanceable by spi^HMS01120/Scer\GAL4^sd.PU

(Austin et al., 2014)

Scer\GAL4^sd.PU, vn^KK108432 has wing vein phenotype, non-enhanceable by Scer\GAL4^sd.PU/spi^JF03322

(Austin et al., 2014)

Suppressor of

Statement

Reference

Scer\GAL4^how-24B/vn^KK108432 is a suppressor of intestinal stem cell phenotype of Scer\GAL4^how-24B, rk^GD15

(Scopelliti et al., 2014)

Scer\GAL4^how-24B/vn^KK108432 is a suppressor of adult midgut phenotype of Scer\GAL4^how-24B, rk^GD15

(Scopelliti et al., 2014)

Scer\GAL4^Mef2.PU/vn^KK108432 is a suppressor of adult midgut phenotype of Burs^Z5569

(Scopelliti et al., 2014)

Scer\GAL4^Mef2.PU/vn^KK108432 is a suppressor of intestinal stem cell | adult stage phenotype of Burs^Z5569

(Scopelliti et al., 2014)

Additional Comments

Genetic Interactions

Statement

Reference

Expression of spi^HMS01120 does not enhance the wing vein phenotypes seen when vn^KK108432 is expressed under the control of Scer\GAL4^sd.PU.

Expression of spi^JF03322 does not enhance the wing vein phenotypes seen when vn^KK108432 is expressed under the control of Scer\GAL4^sd.PU.

(Austin et al., 2014)

Co-expression of vn^KK108432 suppresses the intestinal stem cell hyperproliferation seen in flies expressing rk^GD15 under the control of Scer\GAL4^how-24B.

Expression of vn^KK108432 under the control of Scer\GAL4^Mef2.PU suppresses the intestinal stem cell hyperproliferation seen in Burs^Z5569/Burs^Z5569 mutants.

(Scopelliti et al., 2014)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (1)

VDRC

v109437

P{KK108432}VIE-260B

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (1)

Reported As

Symbol Synonym

vn^KK108432

Name Synonyms

Secondary FlyBase IDs

References (10)

Report Sections

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