FlyBase Allele Report: Dmel\dod[KK108535]

General Information

Symbol

Dmel\dod^KK108535

Species

D. melanogaster

Name

FlyBase ID

FBal0259694

Feature type

allele

Associated gene

Dmel\dod

Associated Insertion(s)

Carried in Construct

P{KK108535}

Key Links

Genomic Maps

JBrowse

Transgenic product class

RNAi_reagent

(Keleman et al., 2009.8.5)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

RNAi_reagent

(Keleman et al., 2009.8.5)

Mutagen

in vitro construct

(Keleman et al., 2009.8.5)

Progenitor genotype

Carried in construct

P{KK108535}

Cytology

Description

UASt regulatory sequences drive expression of an inverted repeat.

(Keleman et al., 2009.8.5)

Allele components

Component

Use(s)

Regulatory region(s)

UASt

binary expression system - regulatory region

Encoded product / tool

dsRNA-KK108535

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

Phenotype Manifest In

adult brain, with Scer\GAL4^elav-C155

(Napoletano et al., 2021)

eye photoreceptor cell | decreased number, with Scer\GAL4^ninaE.PT

(Napoletano et al., 2021)

nuclear membrane | adult stage, with Scer\GAL4^elav-C155

(Napoletano et al., 2021)

retina, with Scer\GAL4^ninaE.PT

(Napoletano et al., 2021)

Detailed Description

Statement

Reference

Adults expressing dod^KK108535 under the control of Scer\GAL4^elav-C155 exhibit decreased learning, decreased short-term memory and decreased climbing abilities; the brain exhibits a progressive increase in apoptosis, increased DNA damage (γH2Av western blotting), and nuclear envelope invaginations.

Expression under the control of Scer\GAL4^ninaE.PT induces progressive retinal degeneration, with loss of photoreceptor cells.

(Napoletano et al., 2021)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressed by

Statement

Reference

Scer\GAL4^elav-C155, dod^KK108535 has increased cell death | adult stage | progressive phenotype, suppressible | partially by Hsap\PIN1^UAS.cNa, Scer\GAL4^elav-C155

(Napoletano et al., 2021)