FlyBase Allele Report: Dmel\TP53INP[FENLL.UAS]

General Information

Symbol

Dmel\TP53INP^FENLL.UAS

Species

D. melanogaster

Name

FlyBase ID

FBal0260617

Feature type

allele

Associated gene

Dmel\TP53INP

Associated Insertion(s)

Carried in Construct

P{UAS-TP53INP.FENLL}

Key Links

Transgenic product class

wild_type

(Francis et al., 2010)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

wild_type

(Francis et al., 2010)

Mutagen

in vitro construct

(Francis et al., 2010)

Progenitor genotype

Carried in construct

P{UAS-TP53INP.FENLL}

Cytology

Description

UAS regulatory sequences drive expression of the FENLL isoform of DOR.

(Francis et al., 2010)

Allele components

Component

Use(s)

Regulatory region(s)

UAS

binary expression system - regulatory region

Encoded product / tool

TP53INP

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 1 )

Disease

Interaction

References

ameliorates Parkinson's disease 1

modeled by Hsap\SNCA^A30P.UAS

(Dinh et al., 2021)

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

Phenotype Manifest In

adult brain, with Scer\GAL4^elav-C155

(Dinh et al., 2021)

autolysosome | adult stage | increased number, with Scer\GAL4^elav-C155

(Dinh et al., 2021)

Detailed Description

Statement

Reference

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressor of

Statement

Reference

TP53INP^FENLL.UAS/Scer\GAL4^Mef2.PU is a suppressor | partially of increased size | adult stage phenotype of Pink1^B9

(Dinh et al., 2021)

TP53INP^FENLL.UAS, Scer\GAL4^ple.PU is a suppressor of abnormal locomotor behavior | adult stage | progressive phenotype of Pink1^JF01203, Scer\GAL4^ple.PU

(Dinh et al., 2021)

Scer\GAL4^ple.PU/TP53INP^FENLL.UAS is a suppressor of abnormal locomotor behavior | adult stage | progressive phenotype of Scer\GAL4^ple.PU, park^HMS01800

(Dinh et al., 2021)

TP53INP^FENLL.UAS, Scer\GAL4^elav-C155 is a suppressor of abnormal locomotor behavior | adult stage | progressive phenotype of Hsap\SNCA^A30P.UAS, Scer\GAL4^elav-C155

(Dinh et al., 2021)

Phenotype Manifest In

Suppressor of

Statement

Reference

TP53INP^FENLL.UAS/Scer\GAL4^Mef2.PU is a suppressor | partially of mitochondrion | adult stage phenotype of Pink1^B9

(Dinh et al., 2021)

TP53INP^FENLL.UAS/Scer\GAL4^Mef2.PU is a suppressor | partially of mitochondrial membrane | adult stage phenotype of Pink1^B9

(Dinh et al., 2021)

TP53INP^FENLL.UAS/Scer\GAL4^Mef2.PU is a suppressor | partially of dorsal longitudinal indirect flight muscle cell | adult stage phenotype of Pink1^B9

(Dinh et al., 2021)

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Rescues

TP53INP^FENLL.UAS/Scer\GAL4^Tub.PU rescues TP53INP^KO

(Francis et al., 2010)

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (3)

Reported As

Symbol Synonym

DOR^{FENLL.Scer\UAS}

DOR^FENLL.UAS

TP53INP^FENLL.UAS

Name Synonyms

Secondary FlyBase IDs

References (2)

Report Sections

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