Allele Dmel\Zif^1L15

General Information
Symbol	Dmel\Zif^1L15	Species	D. melanogaster
Name		FlyBase ID	FBal0260628
Feature type	allele	Associated gene	Dmel\Zif

Map ( GBrowse )
Allele class
Mutagen	ethyl methanesulfonate
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Nature of the Allele
Allele class
Mutagen	ethyl methanesulfonate (Chang et al., 2010)
Mutations Mapped to the Genome

Type Location Additional Notes References point mutation 3R:2,283,395..2,283,395 na_change=C2283395T pr_change=Q109 \| Zif-PA; Q109 \| Zif-PB reported_pr_change=Q110@ comment=Site of nucleotide substitution in mutant inferred by FlyBase based on reported amino acid change. The mutation was mapped to residue 109 in the reference sequence even though residue 110 (the reported location) is also Gln because the locations of the other two mutations mapped from FBrf0212286 differed by one in the reference sequence relative to the reported position. (Chang et al., 2010)
Associated Sequence Data
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name

UniProtKB/Swiss-Prot
UniProtKB/TrEMBL

Progenitor genotype
Nature of the lesion	Statement Reference Amino acid replacement: Q110@. (Chang et al., 2010)
Cytology
Phenotypic Data
Phenotypic Class
	lethal \| embryonic stage (Chang et al., 2010) neuroanatomy defective \| somatic clone (Chang et al., 2010)
Phenotype Manifest In
	neuroblast \| somatic clone \| supernumerary (Chang et al., 2010)
Detailed Description
	Statement Reference Zif[1L15] mutant clones exhibit supernumerary neuroblast-like cells (labeled by mira). Zif[1L15] mutant type-I neuroblast clones exhibit an overgrowth of neuroblast formation. This occurs at the expense of neuron formation, as very few elav-positive neurons are observed in these clones. Type-II Zif[1L15] clones exhibit an increased number of neuroblasts. (Chang et al., 2010)
External Data
Linkouts
Interactions
	Show the genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Suppressed by
Statement Reference Zif^1L15 has neuroanatomy defective \| somatic clone phenotype, suppressible by aPKC^k06403/aPKC[+] (Chang et al., 2010) Zif^1L15 has neuroanatomy defective \| somatic clone phenotype, suppressible by Scer\GAL4^elav-C155/l(2)gl^{3A.Scer\UAS.P\T} (Chang et al., 2010)
Phenotype Manifest In
Suppressed by
Statement Reference Zif^1L15 has neuroblast \| supernumerary \| somatic clone phenotype, suppressible by aPKC^k06403/aPKC[+] (Chang et al., 2010) Zif^1L15 has neuroblast \| supernumerary \| somatic clone phenotype, suppressible by Scer\GAL4^elav-C155/l(2)gl^{3A.Scer\UAS.P\T} (Chang et al., 2010)
Additional Comments
Genetic Interactions
Statement Reference The neuroblast overgrowth phenotype seen in Zif[1L15] mutant clones is significantly suppressed in a aPKC[k06403] heterozygous background. Overexpression of l(2)gl[3A.Scer\UAS.P\T] under the control of Scer\GAL4[elav-C155] suppresses the neuroblast overgrowth phenotype found in Zif[1L15] mutant clones. (Chang et al., 2010)
Xenogenetic Interactions
Statement Reference
Complementation & Rescue Data
Comments
Stocks ( 0 )

Notes on Origin
Discoverer

External Crossreferences & Linkouts
Other Crossreferences

Linkouts

Synonyms & Secondary IDs ( 1 )
Reported As
Symbol Synonym	Zif^1L15 (Chang et al., 2010)
Name Synonym
Secondary FlyBase IDs

References ( 1 )
Research paper	Chang et al., 2010, Dev. Cell 19(5): 778--785 Interplay between the Transcription Factor Zif and aPKC Regulates Neuroblast Polarity and Self-Renewal. [FBrf0212286]

Allele Dmel\Zif1L15

Allele Dmel\Zif^1L15