FlyBase Allele Report: Dmel\Stat92E[UAS.EGFP]

General Information

Symbol

Dmel\Stat92E^UAS.EGFP

Species

D. melanogaster

Name

FlyBase ID

FBal0260716

Feature type

allele

Associated gene

Dmel\Stat92E

Associated Insertion(s)

Carried in Construct

P{UAS-Stat92E.EGFP}

Also Known As

UAS-STAT92E-GFP, UAS-Stat-GFP

Key Links

Transgenic product class

wild_type

(Karsten et al., 2006)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

wild_type

(Karsten et al., 2006)

Mutagen

in vitro construct

(Karsten et al., 2006)

Progenitor genotype

Carried in construct

P{UAS-Stat92E.EGFP}

Cytology

Description

UASt regulatory sequences drive expression of the open reading frame of full-length Stat92E (splice form RC) which is tagged at the C-terminal end with EGFP.

(Karsten et al., 2006)

Allele components

Component

Use(s)

Regulatory region(s)

UASt

binary expression system - regulatory region

Encoded product / tool

Stat92E

Tagged with

EGFP

green fluorescent protein

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 1 )

Disease

Interaction

References

ameliorates tauopathy

modeled by Hsap\MAPT^UAS.cWa

(Colodner and Feany, 2010)

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

visible, with Scer\GAL4^ey.PU

(Karsten et al., 2006)

Phenotype Manifest In

eye, with Scer\GAL4^ey.PU

(Karsten et al., 2006)

Detailed Description

Statement

Reference

Expression of Stat92E^{Scer\UAS.T:Avic\GFP-EGFP} under the control of Scer\GAL4^ey.PU results in occasional mild roughening of posterior equatorial regions of the eye, but the eye is normal in size.

(Karsten et al., 2006)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressor of

Statement

Reference

Scer\GAL80^ts.αTub84B, Stat92E^UAS.EGFP, Scer\GAL4^repo.PU is a suppressor | partially of increased cell death | adult stage phenotype of Hsap\MAPT^UAS.cWa, Scer\GAL4^repo.PU, Scer\GAL80^ts.αTub84B

(Colodner and Feany, 2010)

Phenotype Manifest In

Suppressor of

Statement

Reference

Scer\GAL80^ts.αTub84B, Stat92E^UAS.EGFP, Scer\GAL4^repo.PU is a suppressor | partially of adult brain phenotype of Hsap\MAPT^UAS.cWa, Scer\GAL4^repo.PU, Scer\GAL80^ts.αTub84B

(Colodner and Feany, 2010)

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

The increased number of apoptotic cells in the brain of adult flies expressing Hsap\MAPT^Scer\UAS.cWa under the control of Scer\GAL4^repo.PU (using tub-Gal80[ts] to minimize the transgene expression during development) is significantly reduced by co-expression of Stat92E^{Scer\UAS.T:Avic\GFP-EGFP}.

(Colodner and Feany, 2010)

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

Stat92E^{Scer\UAS.T:Avic\GFP-EGFP}

Stat92E^UAS.EGFP

Name Synonyms

Secondary FlyBase IDs

References (5)

Report Sections

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