Ovarian cysts, but not fat bodies, from Nup44AΔ15/Df(2R)ED1735 animals accumulate autolysosomes.
Egg chambers from Nup44AΔ15 females often develop without an oocyte and cease to develop beyond stage 5 or 6 of oogenesis.
Nup44AΔ15 mutants are homozygous viable and eclose nearly at the expected Mendelian ratio. However Nup44AΔ15 homozygous females exhibit markedly reduced fecundity, laying just one-quarter the eggs of wild-type controls. The eggs laid by Nup44AΔ15 mutant females hatch at about 40% of the rate of those laid by age-matched wild-type controls.Consistent with reduced fertility, Nup44AΔ15 mutant ovarioles contain fewer egg chambers and exhibit smaller germaria than ovarioles from wild-type females.
Nup44AΔ15 mutant germaria contain wild-type numbers of mitotic ovarian cysts but have a reduction in the number of post-mitotic cysts.
Approximately 20% of Nup44AΔ15 homozygous and Nup44AΔ15/Df(2R)ED1735 transheterozygous mutant egg chambers develop with 16 polyploid nurse cells and no oocyte.
In a fraction of Nup44AΔ15 mutant egg chambers, the centrioles fail to migrate to the posterior of the oocyte. In the mutant egg chambers, the distribution of microtubules is frequently disorganised.
Homozygous Nup44AΔ15 mutants exhibit a mitotic delay during the ovarian cyst division.