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General Information
Symbol
Dmel\rpr87
Species
D. melanogaster
Name
FlyBase ID
FBal0260732
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Allele class
Nature of the Allele
Allele class
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
deletion
Comment:

Estimated endpoints of deletion resulting from the imprecise excision of \P{SUPor-P}KG07184, which is reported as extending from 1860 bp upstream to 661 bp downstream of the rpr transcript. Annotated transcription start site from R5.12 used for the mapping.

Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Cytology
Nature of the lesion
Statement
Reference

A deletion extending 1860 bp 5' of the reaper transcript to 661 bp downstream resulting from the imprecise excision of P{SUPor-P}KG07184.

Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

Homozygous animals do not show a defect in the programmed cell death of vCrz neurons: the neurons are no longer present at 7 hours after puparium formation, as occurs in wild-type.

As in wild type, rpr87 mutant bursCCAP neurons undergo programmed cell death shortly after eclosion.

rpr87 homozygotes do not show a significant increase in abdominal neuroblasts compared to wild-type.

rpr87/Df(3L)X20 does not result in ectopic postembryonic neuroblasts.

Compared with wild-type, there is no appreciable change in the level of DNA-damaged induced apoptosis in homozygous rpr87 mutant eye discs.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
NOT Enhancer of
Statement
Reference
Suppressor of
Statement
Reference

rpr87 is a suppressor of increased cell death | recessive phenotype of Rbf120a

NOT Suppressor of
Other
Phenotype Manifest In
NOT Enhancer of
Suppressor of
Statement
Reference

rpr87 is a suppressor of eye disc phenotype of Rbf120a

NOT Suppressor of
Other
Additional Comments
Genetic Interactions
Statement
Reference

The dendritic field coverage defects and loss of terminal branches observed in class IV dendritic arborizing neurons of third instar larvae expressing nosdsRNA.Scer\UAS.WIZ under the control of Scer\GAL4477 is not suppressed by combination with single copies of both Df(3L)grimC15E and rpr87.

A rpr87 mutant background does not affect the Scer\GAL4GMR.PF>lin-52GD12885 eye phenotype, and the number of dying cells remains unaltered.

rpr87, Df(3L)grimC15E larvae display supernumerary ventral neuroblasts and abnormal central nervous system.

rpr87, Df(3L)grimC15E/Df(3L)MM3 larvae display supernumerary ventral neuroblasts.

The ventral nerve cord of one or two-day-old rpr87, Df(3L)grimC15E/Df(3L)MM2 adults is more than twice as wild-type. The abdominal segments extend far into the abdomen, unlike in the wild-type where they extend just to the caudal thorax. The thoracic segments of the central nervous system are also greatly expanded in the mutants.

A rpr87/Df(3L)H99 background does not suppress the cell death seen when p53GUS.PB is expressed in third instar eye discs under the control of Scer\GAL4GMR.PU.

The level of DNA-damage induced cell death seen in Rbf120a mutant eye discs is clearly reduced in the presence of rpr87. rpr87 does not affect the level or pattern of cell death in Rbf120a mutant eye discs before irradiation treatment.

Xenogenetic Interactions
Statement
Reference

A rpr87 heterozygous background does not rescue the reduced adult eye size found upon expression of Mmus\Gria1Lc.Scer\UAS under the control of Scer\GAL4hs.2sev.

Complementation and Rescue Data
Comments
Images (0)
Mutant
Wild-type
Stocks (1)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (2)
References (11)