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General Information
Symbol
Hsap\SNCAIPUAS.cHa
Species
H. sapiens
Name
Saccharomyces cerevisiae UAS construct of Hernandez-Vargas
FlyBase ID
FBal0260868
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Allele class
Nature of the Allele
Allele class
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Carried in construct
Cytology
Nature of the lesion
Statement
Reference

UAS regulatory sequences drive expression of Hsap\SNCAIP.

Allele components
Product class / Tool use(s)
Encoded product / tool
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 1 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 1 )
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

Expression of Hsap\SNCAIPScer\UAS.cHa under the control of Scer\GAL4elav-C155 leads to toxicity and ultrastructural abnormalities in ommatidia.

Expression of Hsap\SNCAIPScer\UAS.cHa under the control of Scer\GAL4ple.PF causes a significant reduction in the number of dopaminergic neurons.

Expression of Hsap\SNCAIPScer\UAS.cHa under the control of Scer\GAL4unspecified causes decreased motility and premature death.

Flies over-expressing Hsap\SNCAIPScer\UAS.cHa under the control of Scer\GAL4unspecified display abnormalities in their electroretinograms (ERG). The ERGs have significantly augmented on- and off-transients. The amplitude of the sustained component of the photoreceptor potential (PP) and the overshoot (OS) are also affected. Treatment with L-Dopa/carbidopa reverts the effect of the over-expression of the transgene.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Phenotype Manifest In
Additional Comments
Genetic Interactions
Statement
Reference
Xenogenetic Interactions
Statement
Reference

Co-expression of Hsap\SNCAIPScer\UAS.cHa and Hsap\SNCAScer\UAS.cFa under the control of Scer\GAL4elav-C155 suppresses the ommatidium phenotype resulting from the expression of either transgene alone.

Co-expression of Hsap\SNCAIPScer\UAS.cHa and Hsap\SNCAScer\UAS.cFa under the control of Scer\GAL4ple.PF increases the number of dopaminergic neurons compared with wild-type or the expression-phenotype of either transgene alone.

Flies co-expressing Hsap\SNCAIPScer\UAS.cHa and Hsap\SNCAScer\UAS.cFa via Scer\GAL4unspecified show reduction in age-associated motility and mortality very similar to that of wild-type controls.

Complementation and Rescue Data
Comments
Images (0)
Mutant
Wild-type
Stocks (0)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (3)
Reported As
Symbol Synonym
Hsap\SNCAIPScer\UAS.cHa
Hsap\SNCAIPUAS.cHa
Name Synonyms
Saccharomyces cerevisiae UAS construct of Hernandez-Vargas
Secondary FlyBase IDs
    References (1)