FlyBase Allele Report: Dmel\NetA[Δ]

General Information

Symbol

Dmel\NetA^Δ

Species

D. melanogaster

Name

FlyBase ID

FBal0260873

Feature type

allele

Associated gene

Dmel\NetA

Associated Insertion(s)

Carried in Construct

Key Links

Genomic Maps

JBrowse

Allele class

Mutagen

P-element activity

Nature of the Allele

Allele class

Mutagen

P-element activity

(Brankatschk and Dickson, 2006)

Progenitor genotype

P{GT1}NetA^BG02298

(Brankatschk and Dickson, 2006)

Cytology

Description

A 4816 bp deletion resulting from the imprecise excision of P{GT1}NetA^BG02298 removing promoter sequences and the first 367 codons of NetA.

(Brankatschk and Dickson, 2006)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

deletion

X:14,652,143..14,656,958 [-]

Comment:

Approximate boundaries of 4816 bp deletion resulting from the imprecise excision of P{GT1}NetABG02298. The deletion removes the first 367 codons (first coding exon) of NetA and part of the 5' UTR. It is not clear if the deletion extends into the first intron.

(Brankatschk and Dickson, 2006)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal neuroanatomy | embryonic stage

(von Hilchen et al., 2010)

Phenotype Manifest In

larval glial cell | embryonic stage

(von Hilchen et al., 2010)

Detailed Description

Statement

Reference

Rh6-positive R8 axons target correctly to the M3 layer in the optic lobe in NetA^Δ mutants.

(Timofeev et al., 2012)

Some hemisegments in mutant embryos have ectopic glial cell clusters in the dorsal periphery.

(von Hilchen et al., 2010)

The commissural axons appear to form normally in homozygous NetA^Δ mutants. Both the anterior and posterior commissures are intact and of normal size in every segment in the NetA^Δ mutants.

(Brankatschk and Dickson, 2006)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressor of

Statement

Reference

NetA^Δ is a suppressor of increased cell death | adult stage phenotype of hid^GMR.PG

(Newquist et al., 2013)

NetB^tm/NetA^Δ is a suppressor of abnormal neuroanatomy phenotype of Scer\GAL4^NP6558, unc-5^UAS.cKa

(Brankatschk and Dickson, 2006)

NOT Suppressor of

Statement

Reference

NetA^Δ is a non-suppressor of abnormal neuroanatomy phenotype of Scer\GAL4^insc-Mz1407, unc-5^UAS.cKa

(Brankatschk and Dickson, 2006)

NetA^Δ is a non-suppressor of abnormal neuroanatomy phenotype of Scer\GAL4^NP6558, unc-5^UAS.cKa

(Brankatschk and Dickson, 2006)

NetB^tm/NetA^Δ is a non-suppressor of abnormal neuroanatomy phenotype of Scer\GAL4^insc-Mz1407, unc-5^UAS.cKa

(Brankatschk and Dickson, 2006)

NetA^Δ/NetB^myc is a non-suppressor of abnormal neuroanatomy phenotype of Scer\GAL4^insc-Mz1407, unc-5^UAS.cKa

(Brankatschk and Dickson, 2006)

NetA^Δ/NetB^myc is a non-suppressor of abnormal neuroanatomy phenotype of Scer\GAL4^NP6558, unc-5^UAS.cKa

(Brankatschk and Dickson, 2006)

Other

Statement

Reference

NetA^Δ, NetB^myc has viable phenotype

(Brankatschk and Dickson, 2006)

NetA^Δ, NetB^myc has fertile phenotype

(Brankatschk and Dickson, 2006)

NetA^Δ, NetB^tm has viable phenotype

(Brankatschk and Dickson, 2006)

NetA^Δ, NetB^tm has fertile phenotype

(Brankatschk and Dickson, 2006)

Phenotype Manifest In

Suppressor of

Statement

Reference

NetA^Δ is a suppressor of eye phenotype of hid^GMR.PG

(Newquist et al., 2013)

NetB^tm/NetA^Δ is a suppressor of larval longitudinal connective phenotype of Scer\GAL4^NP6558, unc-5^UAS.cKa

(Brankatschk and Dickson, 2006)

NOT Suppressor of

Statement

Reference

NetA^Δ is a non-suppressor of larval ventral nerve cord commissure phenotype of Scer\GAL4^insc-Mz1407, unc-5^UAS.cKa

(Brankatschk and Dickson, 2006)

NetA^Δ is a non-suppressor of larval longitudinal connective phenotype of Scer\GAL4^NP6558, unc-5^UAS.cKa

(Brankatschk and Dickson, 2006)

NetB^tm/NetA^Δ is a non-suppressor of larval ventral nerve cord commissure phenotype of Scer\GAL4^insc-Mz1407, unc-5^UAS.cKa

(Brankatschk and Dickson, 2006)

NetA^Δ/NetB^myc is a non-suppressor of larval ventral nerve cord commissure phenotype of Scer\GAL4^insc-Mz1407, unc-5^UAS.cKa

(Brankatschk and Dickson, 2006)

NetA^Δ/NetB^myc is a non-suppressor of larval longitudinal connective phenotype of Scer\GAL4^NP6558, unc-5^UAS.cKa

(Brankatschk and Dickson, 2006)

Additional Comments

Genetic Interactions

Statement

Reference

NetA^Δ partially suppresses the cell death seen in flies expressing W^GMR.PG, resulting in increased eye size.

(Newquist et al., 2013)

A chromosome carrying NetB^{KI.T:Hsap\MYC} and NetA^Δ is able to rescue the viability and fertility defects associated with Df(1)NetAB^Δ. The male courtship behaviour defects are not rescued.

(Newquist et al., 2013)

The ventral nerve cord commissures appear normal in NetA^Δ, NetB^{KI.T:Hsap\MYC} embryos. Similarly to wild-type, both the EW and EG axons cross the midline in every segment of NetB^{KI.T:Hsap\MYC}, NetB^{KI.T:SV5\V5,T:Zzzz\TM,T:Hsap\MYC} embryos.

The anterior commissure appears normal in all segments and the posterior commissure appears normal in most of the segments in NetA^Δ, NetB^{KI.T:SV5\V5,T:Zzzz\TM,T:Hsap\MYC} double mutant embryos. Similarly to wild-type, both the EW and EG axons cross the midline in every segment of NetA^Δ, NetB^{KI.T:SV5\V5,T:Zzzz\TM,T:Hsap\MYC} embryos.

NetA^Δ, NetB^{KI.T:SV5\V5,T:Zzzz\TM,T:Hsap\MYC} animals are viable and fertile with no obvious morphological phenotype.

NetA^Δ, NetB^{KI.T:Hsap\MYC} animals are viable and fertile with no obvious morphological phenotype.

Both ventral nerve cord commissures are absent in every segment of embryos expressing unc-5^Scer\UAS.cKa under the control of Scer\GAL4¹⁴⁰⁷ in a homozygous NetA^Δ mutant genetic background.

Homozygous NetA^Δ has little effect on long-range repulsion of axons expressing unc-5^Scer\UAS.cKa under the control of Scer\GAL4^ato-NP6558.

(Brankatschk and Dickson, 2006)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (1)

Bloomington

66878

w¹¹¹⁸ NetA^Δ

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (5)

Reported As

Symbol Synonym

Net^Δ

(Newquist et al., 2013)

NetA(-)

(Newquist et al., 2013)

NetA-Delta

(Lapraz et al., 2023)

NetA^Δ

(Liu et al., 2024, Kang et al., 2019, Suzuki et al., 2018, Asadzadeh et al., 2016, Newquist et al., 2013, Timofeev et al., 2012, von Hilchen et al., 2010, Brankatschk and Dickson, 2006)

NetAΔ

(Lapraz et al., 2023)

Name Synonyms

Secondary FlyBase IDs

References (10)

Report Sections

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